Protein Alignment usp and nhr-35

DIOPT Version :10

• Sequence 1: NP_476781.1
• Gene: usp / 31165
• FlyBaseID: FBgn0003964
• Length: 508
• Species: Drosophila melanogaster
• Sequence 2: NP_001024365.1
• Gene: nhr-35 / 180725
• WormBaseID: WBGene00003628
• Length: 542
• Species: Caenorhabditis elegans
• Alignment Length: 421
• Identity: 103/421 - (24%)
• Similarity: 176/421 - (41%)
• Gaps: 83/421 - (19%)

  Fly   103 LCSICGDRASGKHYGVYSCEGCKGFFKRTVRKDLTYACRENRNCIIDKRQRNRCQYCRYQKCLTC 167
            :|.||.|.|:|:|||..:|.||||||:||||::..|.||....|.|||..|..|:|||:.||::.
 Worm    76 ICHICSDVATGRHYGAIACNGCKGFFRRTVRRNYEYHCRFESKCEIDKHNRAVCRYCRFMKCISS 140

  Fly   168 GMKREAVQEERQ-RGARNAAGRLSASGGGSSGPGSVGGSSSQGGGGGGGVSGGMGSGNGSDDFMT 231
            ||:.:.||.||. .|.|.....:...   ...|                      :...|.:...
 Worm   141 GMRDDQVQSERDVIGKREKKDNMKTY---CQDP----------------------TPRTSPELTM 180

  Fly   232 NSVSRDFS--IERIIEAEQRAE-------TQCGDRALTFLRVGPYSTVQPDYKGAVSALCQVVNK 287
            :.|..::.  :|.::::|...:       ||.|:...|.......|  ..|....::.:.:.::.
 Worm   181 SPVEDEYDQLLESLLKSEMTIQSLRDTVITQTGNVEYTTKSKNRLS--HTDRTATLNDVLKSMHS 243

  Fly   288 QLFQMVEYARMMPHFAQVPLDDQVILLK---AAWIELLIANVAWCSIVSLDDGGAGGGGGGLGHD 349
            ||..::|:|:.:|.|.|:...||.:|||   ...:.|.:|
 Worm   244 QLLLVIEWAKTLPEFKQLSGADQAVLLKNFAGQHVTLCVA------------------------- 283

  Fly   350 GSFERRSPGLQPQQLFLNQSFSYHRNSA---IKAGVSAIF----DRILSELSVKMKRLNLDRREL 407
                .||.|.......||..:....:..   :|..|...:    ::::.:|...|:.|.||.:|.
 Worm   284 ----YRSVGANDALKLLNDLYIPRASKTTPHLKEYVDGFYLRDCEKVMDQLVEPMRFLKLDNKEF 344

  Fly   408 SCLKAIILYNPDIRGIKSRAE--IEMCREKVYACLDEHCRLEHPGDDGRFAQL-LLRLPALRSIS 469
            ..|||.:|:||...|:.:.|.  :...|.|::|..:::.|:..|.:..|...| ...|..|..:|
 Worm   345 VALKACVLFNPVAPGLSNHAVNLVLNARRKIFAAFEKYVRVNKPLETTRVGDLTFFILTPLSVLS 409

  Fly   470 LKCQDHLFLFRITS----DRPLEELFLEQLE 496
            ....:.:...:::.    |..:|||.|.:.:
 Worm   410 KSISEDIMFTKVSGVARIDVLMEELILAETD 440

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
usp	NP_476781.1	NR_DBD_RXR	102..178	CDD:143514	38/74 (51%)
		NR_LBD_RXR_like	237..480	CDD:132741	53/264 (20%)
nhr-35	NP_001024365.1	NR_DBD_HNF4A	77..152	CDD:143518	39/74 (53%)
		NR_LBD	230..434	CDD:472173	47/232 (20%)