Protein Alignment usp and Nr2f1

DIOPT Version :10

• Sequence 1: NP_476781.1
• Gene: usp / 31165
• FlyBaseID: FBgn0003964
• Length: 508
• Species: Drosophila melanogaster
• Sequence 2: NP_034281.2
• Gene: Nr2f1 / 13865
• MGIID: 1352451
• Length: 420
• Species: Mus musculus
• Alignment Length: 486
• Identity: 150/486 - (30%)
• Similarity: 210/486 - (43%)
• Gaps: 99/486 - (20%)

  Fly    23 ISQLNDSNNSSFSPKAESPVPFMQAMSMVHVLPGSNSASSNNNSAGDAQMAQAPNSAGGSA---A 84
            :|...|..:.........|.|..||..      |..........:|.....|.|...|..|   .
Mouse     5 VSSWRDPQDDVAGGNPGGPNPAAQAAR------GGGGGEQQQAGSGAPHTPQTPGQPGAPATPGT 63

  Fly    85 AAVQQQYPPNHPLSGSKHLCSICGDRASGKHYGVYSCEGCKGFFKRTVRKDLTYACRENRNCIID 149
            |..:.|.||....|.....|.:|||::||||||.::|||||.||||:||::|||.||.||||.||
Mouse    64 AGDKGQGPPGSGQSQQHIECVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLTYTCRANRNCPID 128

  Fly   150 KRQRNRCQYCRYQKCLTCGMKREAVQEERQRGARNAAGRLSASGGGSSGPGSVGGSSSQGGGGGG 214
            :..||:|||||.:|||..||:|||||..|....:...|:.:.:.|...
Mouse   129 QHHRNQCQYCRLKKCLKVGMRREAVQRGRMPPTQPNPGQYALTNGDPL----------------- 176

  Fly   215 GVSGGMGSGNGSDDFMTNSVSRDFSIERIIEAEQRAETQCGDRALTFLRVGPYST-------VQP 272
                     || ..:::..:|                        ..||..||.|       :||
Mouse   177 ---------NG-HCYLSGYIS------------------------LLLRAEPYPTSRYGSQCMQP 207

  Fly   273 DYKGAVSALCQVVNKQLFQMVEYARMMPHFAQVPLDDQVILLKAAWIELLIANVAWCSIVSLDDG 337
            :....:..:|::..:.||..||:||.:|.|..:.:.|||.||:..|.||.:.|.|.||:
Mouse   208 NNIMGIENICELAARLLFSAVEWARNIPFFPDLQITDQVSLLRLTWSELFVLNAAQCSM------ 266

  Fly   338 GAGGGGGGLGHDGSFERRSPGLQPQQLF-LNQSFSYHRNSAIKAGVSAIFD--RILSELSVKMKR 399
                                   |..:. |..:...|.:......|.|..|  ||..|...|:|.
Mouse   267 -----------------------PLHVAPLLAAAGLHASPMSADRVVAFMDHIRIFQEQVEKLKA 308

  Fly   400 LNLDRRELSCLKAIILYNPDIRGIKSRAEIEMCREKVYACLDEHCRLEHPGDDGRFAQLLLRLPA 464
            |::|..|.||||||:|:..|..|:...|.||..:||....|:|:.|.::|....||.:||||||:
Mouse   309 LHVDSAEYSCLKAIVLFTSDACGLSDAAHIESLQEKSQCALEEYVRSQYPNQPSRFGKLLLRLPS 373

  Fly   465 LRSISLKCQDHLFLFRITSDRPLEELFLEQL 495
            ||::|....:.||..|:....|:|.|..:.|
Mouse   374 LRTVSSSVIEQLFFVRLVGKTPIETLIRDML 404

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
usp	NP_476781.1	NR_DBD_RXR	102..178	CDD:143514	49/75 (65%)
		NR_LBD_RXR_like	237..480	CDD:132741	73/252 (29%)
Nr2f1	NP_034281.2	NR_DBD_COUP_TF	83..155	CDD:143516	48/71 (68%)
		NR_LBD_COUP-TF	181..416	CDD:132746	79/277 (29%)
		Important for dimerization	341..420		24/64 (38%)