Protein Alignment usp and Nr2f6

DIOPT Version :10

• Sequence 1: NP_476781.1
• Gene: usp / 31165
• FlyBaseID: FBgn0003964
• Length: 508
• Species: Drosophila melanogaster
• Sequence 2: NP_034280.2
• Gene: Nr2f6 / 13864
• MGIID: 1352453
• Length: 390
• Species: Mus musculus
• Alignment Length: 454
• Identity: 140/454 - (30%)
• Similarity: 197/454 - (43%)
• Gaps: 83/454 - (18%)

  Fly    48 MSMVHVLPGSNSASSNNNSAGDAQMAQAPNSAGGSAAAAVQQQYPPNHPLSGSKHLCSICGDRAS 112
            |:||....|.....:|..........:|......|...|.....|.:....|.:..|.:|||::|
Mouse     1 MAMVTGGWGDPGGDTNGVDKAGGSYPRATEDDSASPPGATSDAEPGDEERPGLQVDCVVCGDKSS 65

  Fly   113 GKHYGVYSCEGCKGFFKRTVRKDLTYACRENRNCIIDKRQRNRCQYCRYQKCLTCGMKREAVQEE 177
            ||||||::|||||.||||::|::|:|.||.||:|.||:..||:|||||.:||...||::||||.
Mouse    66 GKHYGVFTCEGCKSFFKRSIRRNLSYTCRSNRDCQIDQHHRNQCQYCRLKKCFRVGMRKEAVQR- 129

  Fly   178 RQRGARNAAGRLSASGGGSSGPGSVGGSSSQGGGGGGGVSGGMGSGNGSDDFMTNSVSRDFSIER 242
                     ||:         |.::.|.::....|..||          :.|....||     |.
Mouse   130 ---------GRI---------PHALPGPAACSPPGATGV----------EPFTGPPVS-----EL 161

  Fly   243 IIEAEQRAETQCGDRALTFLRVGPYSTVQPDYKG----AVSALCQVVNKQLFQMVEYARMMPHFA 303
            |.:               .||..||........|    .:..:|::..:.||..||:||..|.|.
Mouse   162 IAQ---------------LLRAEPYPAAGRFGGGGAVLGIDNVCELAARLLFSTVEWARHAPFFP 211

  Fly   304 QVPLDDQVILLKAAWIELLIANVAWCSIVSLDDGGAGGGGGGLGHDGSFERRSPGLQPQQLFLNQ 368
            ::|..|||.||:.:|.||.:.|.|..::..                    ..:|.|....|
Mouse   212 ELPAADQVALLRLSWSELFVLNAAQAALPL--------------------HTAPLLAAAGL---- 252

  Fly   369 SFSYHRNSAIKAGVSAIFD--RILSELSVKMKRLNLDRRELSCLKAIILYNPDIRGIKSRAEIEM 431
                |..........|..|  |...|...|:.||.:|..|..|||||.|:.||..|:...|.:|.
Mouse   253 ----HAAPMAAERAVAFMDQVRAFQEQVDKLGRLQVDAAEYGCLKAIALFTPDACGLSDPAHVES 313

  Fly   432 CREKVYACLDEHCRLEHPGDDGRFAQLLLRLPALRSISLKCQDHLFLFRITSDRPLEELFLEQL 495
            .:||....|.|:.|.::|....||.:|||||||||::.......||..|:....|:|.|..:.|
Mouse   314 LQEKAQVALTEYVRAQYPSQPQRFGRLLLRLPALRAVPASLISQLFFMRLVGKTPIETLIRDML 377

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
usp	NP_476781.1	NR_DBD_RXR	102..178	CDD:143514	45/75 (60%)
		NR_LBD_RXR_like	237..480	CDD:132741	70/248 (28%)
Nr2f6	NP_034280.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..50		9/48 (19%)
		NR_DBD_COUP_TF	57..129	CDD:143516	44/71 (62%)
		NR_LBD_COUP-TF	157..387	CDD:132746	77/269 (29%)
		Important for dimerization. /evidence=ECO:0000250	314..390		24/64 (38%)