Protein Alignment usp and Nr2f2

DIOPT Version :10

• Sequence 1: NP_476781.1
• Gene: usp / 31165
• FlyBaseID: FBgn0003964
• Length: 508
• Species: Drosophila melanogaster
• Sequence 2: NP_542956.1
• Gene: Nr2f2 / 113984
• RGDID: 69305
• Length: 414
• Species: Rattus norvegicus
• Alignment Length: 482
• Identity: 146/482 - (30%)
• Similarity: 212/482 - (43%)
• Gaps: 112/482 - (23%)

  Fly    27 NDSNNSSFSPKAESPVPFMQAMSMVHV--LPGSNSASSNNNSAGDAQMAQAPNSAGGSAAAAVQQ 89
            :..:.:|.:|....|.|     ...|.  .||....:|.     .||.|.......|...:..||
  Rat    18 SQGSQASQAPPVPGPPP-----GAPHTPQTPGQGGPAST-----PAQTAAGSQGGPGGPGSDKQQ 72

  Fly    90 QYPPNHPLSGSKHL-CSICGDRASGKHYGVYSCEGCKGFFKRTVRKDLTYACRENRNCIIDKRQR 153
            |         .:|: |.:|||::||||||.::|||||.||||:||::|:|.||.||||.||:..|
  Rat    73 Q---------QQHIECVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLSYTCRANRNCPIDQHHR 128

  Fly   154 NRCQYCRYQKCLTCGMKREAVQEERQRGARNAAGRLSASGGGSSGPGSVGGSSSQGGGGGGGVSG 218
            |:|||||.:|||..||:|||||..|....:...|:.:.:.|......|
  Rat   129 NQCQYCRLKKCLKVGMRREAVQRGRMPPTQPTHGQFALTNGDPLNCHS----------------- 176

  Fly   219 GMGSGNGSDDFMTNSVSRDFSIERIIEAEQRAETQCGDRALTFLRVGPYST-------VQPDYKG 276
                      :::..:|                        ..||..||.|       :||:...
  Rat   177 ----------YLSGYIS------------------------LLLRAEPYPTSRFGSQCMQPNNIM 207

  Fly   277 AVSALCQVVNKQLFQMVEYARMMPHFAQVPLDDQVILLKAAWIELLIANVAWCSIVSLDDGGAGG 341
            .:..:|::..:.||..||:||.:|.|..:.:.|||.||:..|.||.:.|.|.||:
  Rat   208 GIENICELAARMLFSAVEWARNIPFFPDLQITDQVALLRLTWSELFVLNAAQCSM---------- 262

  Fly   342 GGGGLGHDGSFERRSPGLQPQQLF-LNQSFSYHRNSAIKAGVSAIFD--RILSELSVKMKRLNLD 403
                               |..:. |..:...|.:......|.|..|  ||..|...|:|.|::|
  Rat   263 -------------------PLHVAPLLAAAGLHASPMSADRVVAFMDHIRIFQEQVEKLKALHVD 308

  Fly   404 RRELSCLKAIILYNPDIRGIKSRAEIEMCREKVYACLDEHCRLEHPGDDGRFAQLLLRLPALRSI 468
            ..|.||||||:|:..|..|:...|.:|..:||....|:|:.|.::|....||.:||||||:||::
  Rat   309 SAEYSCLKAIVLFTSDACGLSDVAHVESLQEKSQCALEEYVRSQYPNQPTRFGKLLLRLPSLRTV 373

  Fly   469 SLKCQDHLFLFRITSDRPLEELFLEQL 495
            |....:.||..|:....|:|.|..:.|
  Rat   374 SSSVIEQLFFVRLVGKTPIETLIRDML 400

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
usp	NP_476781.1	NR_DBD_RXR	102..178	CDD:143514	49/76 (64%)
		NR_LBD_RXR_like	237..480	CDD:132741	72/252 (29%)
Nr2f2	NP_542956.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..72		12/63 (19%)
		NR_DBD_COUP_TF	79..151	CDD:143516	47/71 (66%)
		Interaction with ZFPM2. /evidence=ECO:0000250	117..414		105/364 (29%)
		NR_LBD_COUP-TF	177..411	CDD:132746	78/277 (28%)
		Important for dimerization	337..414		24/64 (38%)