Protein Alignment usp and NR2E3

DIOPT Version :10

• Sequence 1: NP_476781.1
• Gene: usp / 31165
• FlyBaseID: FBgn0003964
• Length: 508
• Species: Drosophila melanogaster
• Sequence 2: NP_055064.1
• Gene: NR2E3 / 10002
• HGNCID: 7974
• Length: 410
• Species: Homo sapiens
• Alignment Length: 445
• Identity: 129/445 - (28%)
• Similarity: 212/445 - (47%)
• Gaps: 60/445 - (13%)

  Fly    70 AQMAQAPNSAGGSAAAAVQQQYP-----PNHPLSGSKHL-CSICGDRASGKHYGVYSCEGCKGFF 128
            |.|:....:|..:|.||.:::.|     ...|...|..| |.:|||.:||||||:|:|.||.|||
Human     7 ALMSSTVAAAAPAAGAASRKESPGRWGLGEDPTGVSPSLQCRVCGDSSSGKHYGIYACNGCSGFF 71

  Fly   129 KRTVRKDLTYACRENRN-CIIDKRQRNRCQYCRYQKCLTCGMKREAVQEERQRGARNAAGRLSAS 192
            ||:||:.|.|.|:.... |.:||..||:||.||.:|||..||.::|||.|||..:.......|..
Human    72 KRSVRRRLIYRCQVGAGMCPVDKAHRNQCQACRLKKCLQAGMNQDAVQNERQPRSTAQVHLDSME 136

  Fly   193 GGGSSGPGSVGGSSSQGGGGGGG---VSGGMGSGNGSDDFMTNSVSRDFSIERIIE-AEQRAETQ 253
            ....|.|.|:....:..|....|   :|.....|:   .||.:.::.:...:...| |::..:..
Human   137 SNTESRPESLVAPPAPAGRSPRGPTPMSAARALGH---HFMASLITAETCAKLEPEDADENIDVT 198

  Fly   254 CGDRALTFLRVGPYSTVQPDYKGAVSALCQVVNKQLFQMVEYARMMPHFAQVPLDDQVILLKAAW 318
            ..|....   ..|||:..|   ..:.::.:...:.||..|::|:.:|.|:.:|..||||||:.||
Human   199 SNDPEFP---SSPYSSSSP---CGLDSIHETSARLLFMAVKWAKNLPVFSSLPFRDQVILLEEAW 257

  Fly   319 IEL-LIANVAW------CSIVSLDDGGAGGGGGGLGHDGSFERRSPGLQPQQLFLNQSFSYHRNS 376
            .|| |:..:.|      |.:::..:..|.||..|
Human   258 SELFLLGAIQWSLPLDSCPLLAPPEASAAGGAQG------------------------------- 291

  Fly   377 AIKAGVSAIFDRILSELSVKMKRLNLDRRELSCLKAIILYNPDIRGIKSRAEIEMCREKVYACLD 441
              :..::::..|:|.|...:.:.|.:|..|.:|:||::|:.|:.||:|....:|..:::....|.
Human   292 --RLTLASMETRVLQETISRFRALAVDPTEFACMKALVLFKPETRGLKDPEHVEALQDQSQVMLS 354

  Fly   442 EHCRLEHPGDDGRFAQLLLRLPALRSISLKCQDHLFLFRITSDRPLEELFLEQLE 496
            :|.:..||....||.:|||.||:||.|:.:..:.||..:...:.|:|:|..:..:
Human   355 QHSKAHHPSQPVRFGKLLLLLPSLRFITAERIELLFFRKTIGNTPMEKLLCDMFK 409

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
usp	NP_476781.1	NR_DBD_RXR	102..178	CDD:143514	42/77 (55%)
		NR_LBD_RXR_like	237..480	CDD:132741	62/250 (25%)
NR2E3	NP_055064.1	NR_DBD_PNR	39..130	CDD:143528	46/90 (51%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	118..162		11/43 (26%)
		NR_LBD_Tlx_PNR_like	192..397	CDD:132748	60/243 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	193..215		5/27 (19%)