Protein Alignment Edem1 and EDEM2

DIOPT Version :10

• Sequence 1: NP_001259152.1
• Gene: Edem1 / 31154
• FlyBaseID: FBgn0023511
• Length: 1004
• Species: Drosophila melanogaster
• Sequence 2: NP_060687.2
• Gene: EDEM2 / 55741
• HGNCID: 15877
• Length: 578
• Species: Homo sapiens
• Alignment Length: 561
• Identity: 308/561 - (54%)
• Similarity: 391/561 - (69%)
• Gaps: 30/561 - (5%)

  Fly     5 PRNNGYPGTLICAVLLVLLSTGVSGQKQYSKARKLELREDVRRMFQHAYDGYLRHASNYDELRPL 69
            |:::|.||                  ...|.......||.|:.||.||||.||.:|..:||||||
Human    17 PQHHGAPG------------------PDGSAPDPAHYRERVKAMFYHAYDSYLENAFPFDELRPL 63

  Fly    70 TCDGHDTWGSYSLTLIDALDTLATMGNFTEFRRAARLLEEKMDFDRDINVSVFETNIRIVGGLLS 134
            ||||||||||:|||||||||||..:||.:||:|...:|::.:|||.|:|.||||||||:||||||
Human    64 TCDGHDTWGSFSLTLIDALDTLLILGNVSEFQRVVEVLQDSVDFDIDVNASVFETNIRVVGGLLS 128

  Fly   135 AHLLSKRAGVELEPGWPCKGPLLRLAEDVARRLLPAFVTNTGMPYGTVNLRYGVPKGETSITCTA 199
            ||||||:||||:|.||||.|||||:||:.||:|||||.|.||||||||||.:||..|||.:||||
Human   129 AHLLSKKAGVEVEAGWPCSGPLLRMAEEAARKLLPAFQTPTGMPYGTVNLLHGVNPGETPVTCTA 193

  Fly   200 GVGTFLIEFGTLSRLTGKTIYEDVAMKAVHALWAYRSPIGLFGNHIDVQSGRWTALDSGIGAGVD 264
            |:|||::||.|||.|||..::||||..|:..||..||.|||.||||||.:|:|.|.|:|||||||
Human   194 GIGTFIVEFATLSSLTGDPVFEDVARVALMRLWESRSDIGLVGNHIDVLTGKWVAQDAGIGAGVD 258

  Fly   265 SLFEYLVKASVLLNRPELLELFHEARAAIDKYMRKEDWYVWVGMNKGRVTLPVFQSLEAFWPGIL 329
            |.||||||.::||...:|:.:|.|...||..|.|.:|||:||.|.||.|::||||||||:|||:.
Human   259 SYFEYLVKGAILLQDKKLMAMFLEYNKAIRNYTRFDDWYLWVQMYKGTVSMPVFQSLEAYWPGLQ 323

  Fly   330 SIIGDTEPALRTISRYIGVWKKYGFLPEFYNIAAGEASPNREVYPLRPELIESAMYLYRATGNEY 394
            |:|||.:.|:||...|..|||::|.|||||||..|.....||.|||||||||||||||||||:..
Human   324 SLIGDIDNAMRTFLNYYTVWKQFGGLPEFYNIPQGYTVEKREGYPLRPELIESAMYLYRATGDPT 388

  Fly   395 LLEFGEHMLETLEFSAKTKCGYATIRNVVTHEKENRMESFFLAETSKYLYLLFDEENFLHNDGSG 459
            |||.|...:|::|..:|.:||:|||:::..|:.:|||||||||||.||||||||..||:||:||.
Human   389 LLELGRDAVESIEKISKVECGFATIKDLRDHKLDNRMESFFLAETVKYLYLLFDPTNFIHNNGST 453

  Fly   460 GELLSTEDDVCVVQAGAYIFNTEAHPMDMSALHCCHAHNEDIYTSLDLQR--FSPRAILERSK-- 520
            .:.:.|....|::.||.|||||||||:|.:|||||....|:.:...||.|  :|    |:||:
Human   454 FDAVITPYGECILGAGGYIFNTEAHPIDPAALHCCQRLKEEQWEVEDLMREFYS----LKRSRSK 514

  Fly   521 -KRQVAVQEQWVPQCHPENNEFFNKEDESVQAQDSEKEQER 560
             ::.......|.|...|  ...|:.|:.. ||::.:..:::
Human   515 FQKNTVSSGPWEPPARP--GTLFSPENHD-QARERKPAKQK 552

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Edem1	NP_001259152.1	Glyco_hydro_47	48..486	CDD:460241	278/437 (64%)
EDEM2	NP_060687.2	Glyco_hydro_47	42..480	CDD:460241	278/437 (64%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	517..557		7/39 (18%)