Protein Alignment Edem1 and Edem2

DIOPT Version :10

• Sequence 1: NP_001259152.1
• Gene: Edem1 / 31154
• FlyBaseID: FBgn0023511
• Length: 1004
• Species: Drosophila melanogaster
• Sequence 2: XP_314865.4
• Gene: Edem2 / 1275602
• VectorBaseID: AGAMI1_014653
• Length: 806
• Species: Anopheles gambiae
• Alignment Length: 803
• Identity: 257/803 - (32%)
• Similarity: 384/803 - (47%)
• Gaps: 169/803 - (21%)

  Fly    14 LICAVLLVLLSTGVSGQ------KQYSKARKLELREDVRRMFQHAYDGYLRHASNYDELRPLTCD 72
            ::.||:|...:..::.|      ...|...:.||:|:.|.||.|||..|:.:|...|||.||:|.
Mosquito    29 MLTAVVLGWATLALAEQIPTVPTHNMSNKERNELKEEAREMFYHAYRAYMDNAYPADELMPLSCA 93

  Fly    73 GH------------DTWGSYSLTLIDALDTLATMGNFTEFRRAARLLEEKMDFDRDINVSVFETN 125
            |.            ||.|::|:||:|.||||..:|:..||..|.:|:.:.:.||.||.|||||||
Mosquito    94 GRYRGVTPSRGDLDDTLGNFSMTLVDTLDTLVVLGDLEEFEHAVKLVIKDVKFDNDIIVSVFETN 158

  Fly   126 IRIVGGLLSAHLLS----KRAGVELEPGWPCKGPLLRLAEDVARRLLPAFVTNTGMPYGTVNLRY 186
            ||::|||||.|:|:    |:|.|..   | .:|.||.:|:|:..||||||.|:||:|:..|||::
Mosquito   159 IRMIGGLLSGHILAEYVQKQADVMT---W-YRGELLEMAKDLGYRLLPAFNTSTGIPHARVNLKH 219

  Fly   187 GVPKGE----TSITCTAGVGTFLIEFGTLSRLTGKTIYEDVAMKAVHALWAYRSPIG-LFGNHID 246
            |: |.|    :..||||..||.|:||..||||:|:.|:|..|..|:.|||..|.... |.|..::
Mosquito   220 GM-KVEALRHSRETCTACAGTILLEFAALSRLSGEPIFEVKAHAAMDALWKMRHRSSELMGTVLN 283

  Fly   247 VQSGRWTALDSGIGAGVDSLFEYLVKASVLLNRPELLELFHEARAAIDKYMRKEDWYVWVGMNKG 311
            |.||.|...:||:|||:||.:||.:|:.:||.....|..|:....||.||:.:....:.|.|::.
Mosquito   284 VHSGDWIRRESGVGAGIDSYYEYCLKSYILLGDERYLARFNRHYHAIMKYISQGPMLLDVQMHRP 348

  Fly   312 RV-TLPVFQSLEAFWPGILSIIGDTEPALRTISRYIGVWKKYGFLPEF----YNIAAGEASPNRE 371
            .. |.....:|.|||||:..:.||.:||::|......|.:.:.|:||.    :.:..|:
Mosquito   349 HTKTRNFMDALLAFWPGLQVLSGDLKPAVQTHEMLYQVMQMHTFIPEAFTFDFQVHWGQ------ 407

  Fly   372 VYPLRPELIESAMYLYRATGNEYLLEFGEHMLETLEFSAKTKCGYATIRNVVTHEKENRMESFFL 436
             :.||||.|||..:||||||:.|.|..|:..|:.|:..|:..||||.:.:|.|.:.|:||:|:.|
Mosquito   408 -HHLRPEFIESTYFLYRATGDHYYLHAGKKALKALQKHARVPCGYAAVNDVRTGKHEDRMDSYVL 471

  Fly   437 AETSKYLYLLFDEENFLHNDGSGGELLSTEDDVCVVQAGAYIFNTEAH--PMDMSAL--HC---C 494
            :||.|||:|||.:...|        :|:.||         :||.||||  |:.:..|  |.   .
Mosquito   472 SETFKYLFLLFSDPADL--------ILNIED---------FIFTTEAHLLPLTLGQLGNHTFTGV 519

  Fly   495 HAHNEDIYTSLDLQRF--SPRAILERSKKR----------------------------------- 522
            ...:|.:: .||..|.  ||..:...:.:|
Mosquito   520 RDQDEQVH-MLDYMRSCPSPNKLFPETVRRPLRDLVTGVCPRISSAKRLRAADFQASNTDHLRTV 583

  Fly   523 ------QVAVQEQWVPQCH-------PENNE---FFNKE-----------DESVQAQDSEKEQER 560
                  .|::.|..|...|       ||:.|   .|.:|           :..:||...::|.||
Mosquito   584 YDMGITMVSLGEGKVQLLHSFHNAKSPEDAERGLIFMQEMVELSNSNSIPNTQLQAVAYKREGER 648

  Fly   561 E----QSGTS---TTMAVDIEVFDE--FQQPAGDL-LVSNFEQIREERELNESLHRNVVARNQLT 615
            |    ::|.|   ..:..|:.|...  |.:||... .:.|.|:||.:..        ::.|.:.|
Mosquito   649 EMRILEAGPSHFGMELVNDLAVVQRAVFAKPAKVCSALKNGEEIRGKIV--------IIERGECT 705

  Fly   616 VSDLDEFFAQRRESFASASEAL---NYVKTFMGNYTM--------DVAFIRGLQLYDTNMSSVLG 669
            ..|.    |:|.|| |.|..|:   |...|.:.|..|        |...|..:.|:......::
Mosquito   706 FVDK----ARRVES-AGAVAAIVIDNTPNTSINNQQMFAMSGDGRDDVLIPVVFLFTKEAEQLI- 764

  Fly   670 TGAQKEYESRMRTLWQLYELQQQ 692
             .|.||..|...||..:..|:::
Mosquito   765 -KAIKEQPSLELTLMSVTALKEK 786

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Edem1	NP_001259152.1	Glyco_hydro_47	48..486	CDD:460241	188/465 (40%)
Edem2	XP_314865.4	None