Protein Alignment hfw and swi2

DIOPT Version :10

• Sequence 1: NP_569933.2
• Gene: hfw / 31120
• FlyBaseID: FBgn0001189
• Length: 611
• Species: Drosophila melanogaster
• Sequence 2: NP_611247.3
• Gene: swi2 / 37010
• FlyBaseID: FBgn0034262
• Length: 499
• Species: Drosophila melanogaster
• Alignment Length: 551
• Identity: 134/551 - (24%)
• Similarity: 217/551 - (39%)
• Gaps: 137/551 - (24%)

  Fly   105 DTTSTSTSHSTSTTSTTSPAPLPPAAPEQPEYLKHCFYAEEQLCGHTFDGRAETSEGQGSTVAQS 169
            |:..|||..:|.||.||...|:|.:.       :.||            |.:...|..|...::|
  Fly    32 DSHETSTLLATITTITTEIIPMPDSG-------RSCF------------GWSSAPEAAGGNCSRS 77

  Fly   170 EAQNRGGQGNSQCQCREHPTRPNSWYCCNISQLTMISSCSNISKWTNLHVRNMTVEDMDLSNPIF 234
               ||  .|..:|....:          |::.|......|.:.....:.:.....:.::    .|
  Fly    78 ---NR--NGTLKCYGGMN----------NLAALNQSGKLSRVQPALEMLLCGWPKDGLN----HF 123

  Fly   235 RSLQ------SLAVTDGNITRLVNAFPRLSALKCLNISNNNISEIHSRAVKDVPHLEFFGMSNNN 293
            |.||      ||.:.....|.....||.:..|..:|||..|:|.|.||..|.|..|:...:..|.
  Fly   124 RDLQKLPRLRSLTIEYSGFTEFKFDFPEMLELHTINISWTNLSYISSRTFKRVHPLKVLDLRWNQ 188

  Fly   294 LSLVPHRNQNKNITLDISGNMRMLCTPLN-EIIYTESINFLNPKHSYCQYNATHT--WFQ----- 350
            |           |.||     ..|..|.| |.:|...    ||      :|.|..  |..
  Fly   189 L-----------IQLD-----GPLLLPRNFEQLYLAG----NP------WNCTRNFKWLLLQPEK 227

  Fly   351 -----------STDKVSVE---------QLENRKRCVTNCPVIPNYGSCNCTLENIMIIQDNQSK 395
                       .||:...|         :||.:::|.::    .:..:|.|.:.:|:
  Fly   228 GRLVVDRDELICTDRKYKERQMLMVMHYKLELKRQCQSH----EDLRNCTCLMHHIL-------- 280

  Fly   396 PQCH-----VDCSNLGLVELPQRLPDNTFMLNITNNKITSLGDYFHTNPTYHNINRLLADNNQIS 455
            |:.|     |:||:|....||..|||||..|.|.:|.|:.:.. ...||.|.::..:..:|||||
  Fly   281 PKTHIPLYTVNCSHLQFHRLPDFLPDNTTTLVINDNMISDINP-LRDNPHYRHVVDMQLENNQIS 344

  Fly   456 SIYEFEGTKFIETFQRIYMRNNSLSKIPEYFLNNALMDSGLGRRIYLAGNKLQCDCNSAKTLQNW 520
            ::...|.|.:::.|:.:.:|.|:|.|:..|.|:|||.|:.....:.|:.|...|.|.....::..
  Fly   345 NVDNLEDTYWLQNFRLLNLRGNNLRKLHVYALDNALDDNENANLLLLSRNPWHCTCKFGSRMREL 409

  Fly   521 LKERSSDIPDYMEIRCR------NMPQRVIELQEAKLCQ---------SPPDWTDYIYYLIAAEV 570
            |.:....:.|...:.|.      .:..:|:.|...::|.         .|.||.:.:   :|:.:
  Fly   410 LTKYKDIVRDAWNVSCTYRLDDDQLLAKVLTLSRQEMCNLSVEGGTQIHPIDWLNGV---LASLI 471

  Fly   571 LLLLALITKVSYDYWVFKTAGYLPWPASKMP 601
            .|:|.   |::|||:.:|..|.:||...|||
  Fly   472 FLILG---KLAYDYYYYKYYGRVPWIVMKMP 499

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hfw	NP_569933.2	LRR	<198..>313	CDD:443914	29/120 (24%)
		leucine-rich repeat	237..259	CDD:275378	7/27 (26%)
		leucine-rich repeat	260..283	CDD:275378	11/22 (50%)
		leucine-rich repeat	284..304	CDD:275378	3/19 (16%)
		leucine-rich repeat	420..443	CDD:275378	7/22 (32%)
		leucine-rich repeat	444..465	CDD:275378	7/20 (35%)
		leucine-rich repeat	466..497	CDD:275378	11/30 (37%)
		leucine-rich repeat	498..509	CDD:275378	2/10 (20%)
swi2	NP_611247.3	LRR	<120..479	CDD:443914	100/407 (25%)
		leucine-rich repeat	132..154	CDD:275378	5/21 (24%)
		leucine-rich repeat	155..178	CDD:275378	11/22 (50%)
		leucine-rich repeat	179..201	CDD:275378	8/37 (22%)
		leucine-rich repeat	202..214	CDD:275378	4/21 (19%)