Protein Alignment dor and PEP3

DIOPT Version :10

• Sequence 1: NP_477286.2
• Gene: dor / 31118
• FlyBaseID: FBgn0000482
• Length: 1002
• Species: Drosophila melanogaster
• Sequence 2: NP_013249.1
• Gene: PEP3 / 850840
• SGDID: S000004138
• Length: 918
• Species: Saccharomyces cerevisiae
• Alignment Length: 1025
• Identity: 224/1025 - (21%)
• Similarity: 413/1025 - (40%)
• Gaps: 215/1025 - (20%)

  Fly    59 TG--DLMHLAVSRNWLVCLLGTPERTTLLRFFL--PRAIPPGEAVLEKYLSGSGYKITRMFLDPT 119
            ||  :|.||.||.:.|:.   |.:| |:.|..|  |..:...:..|.|.|.    .|..:.:.|.
Yeast    15 TGNTELTHLKVSNDQLIV---TTQR-TIYRINLQDPAIVNHFDCPLSKELE----TIMNVHVSPM 71

  Fly   120 GHHIIIALVPKSATAGVSPDFLYIHCLESPQAQQL-KVRRIEKFKDHEITAVAFNPYHGNESSTG 183
            |..|:|           ..:|.....|:..:..|| |::.::....|.|....|
Yeast    72 GSVILI-----------RTNFGRYMLLKDGEFTQLNKIKNLDLSSLHWINETTF----------- 114

  Fly   184 PILLGTSR----------GLIFETEL---NPAADGHVQRKQLYDLGLGRPKYPITGLKLLRVPNS 235
              |:|..:          |....|:|   |....|.:.....::           |..||.:.::
Yeast   115 --LMGIKKTPKLYRVELTGKDITTKLWYENKKLSGGIDGIAYWE-----------GSLLLTIKDN 166

  Fly   236 SRYIIVVTSPECIYTFQETLKAEERSLQAIFAGYVSGVQEPHCEERKTDLTFSQLRFFAPPNSKY 300
            ..|...||:.:    |...|..|....:.:          .|...:|.|              .|
Yeast   167 ILYWRDVTNMK----FPLVLPDESEQFERL----------KHHAIKKFD--------------SY 203

  Fly   301 PKQWAWLCGEGIRVGEL---SIEANSAATLIGNTL----INLDFEKTMHLSYGERRLNTPKAFVL 358
            ...:||:...||..|:|   .:|.:.|:...|..|    :.|:||..   .|...:.:..|..||
Yeast   204 NGLFAWVTSNGIVFGDLKEKQMEKDPASNNFGKFLSSSKVLLNFELP---DYQNDKDHLIKDIVL 265

  Fly   359 TEYHAVLLYADHVRAICLLNQEQVYQEAFDEARV--------GKPLSIERDELTGSIYVYTVKTV 415
            |.:|.:||..:.|..:..||.:.|:.|.....::        .|.|.:.||.:..:.:.::...|
Yeast   266 TAFHILLLRKNTVTMVSQLNNDVVFHETIPRHQLTGSNTDSNEKFLGLVRDSVKETFWCFSNINV 330

  Fly   416 FNLRVTREERNVWRIYLDKGQYELATAHAAEDPEHLQLVLCQRADAAFADGSYQVAADYY--AET 478
            |.:.:..|..:||.:.:...:::.|.:........::.|...:|...|     ..|.|::  |:|
Yeast   331 FEIIIENEPNSVWNLLVRDNKFDKALSLKGLTVREIESVKLSKAMYLF-----HTAKDFHSAAQT 390

  Fly   479 -----DKS-FEEVCLKFMVLPDKRPIINYVKKRLSRVTTKPMETDELDEDKMNIIKALVIW---- 533
                 |.| |.|:.|.|:.:.|...:...:.|:|..|..|..:.         ::.:.:||
Yeast   391 LGSMKDLSHFGEIALNFLQIKDYNDLNVILIKQLDNVPWKSTQV---------VLSSWIIWNFMK 446

  Fly   534 -LIDLYL-IQINMPDKDEE-----WRSSWQTEYDEF--MMEAHVLSCTRQNRETVRQLIAEHADP 589
             |.|:.| |....|...:|     |..:.:.:.:|.  .:|:|:   .:.:.|||.|::::....
Yeast   447 QLNDIELKINTTKPASTDEDNLLNWNLNLKEKSNELTKFLESHL---EKLDNETVYQIMSKQNRQ 508

  Fly   590 RNMAQFAIAIGDYDEVVAQQLKAECYAEALQTLINQRNPELFYKYAPELITRLPKPTVDALMAQG 654
            ..:..||..|.|...:::..:....:.|:|:.|:...|.:|.|||:..|:...|:.||...| :.
Yeast   509 NELLIFASLINDMKFLLSFWIDQGNWYESLKILLTINNHDLVYKYSLILLLNSPEATVSTWM-KI 572

  Fly   655 SRLEVEKLVPTLI---------------IMENREQREQTQRYLEFAIYKL-NTTNDAIHNFLLHL 703
            ..|:..||:||::               |.|..|....|  ||::.:.:: ...|..::|.:|::
Yeast   573 KDLDPNKLIPTILKFFTNWQNNSKLITNISEYPENYSLT--YLKWCVREVPKMCNPIVYNSILYM 635

  Fly   704 YAEHEPK--LLMKYLEIQGRDESLVHYDIYYAHKVCTDLDVKEARVFLECMLRKWISAVDLA--- 763
            ... :|:  ::::...|:....:...||:.:..::.......:..:||...|..:..|:|||
Yeast   636 MIT-DPRNDMILENDIIKFMKSNENKYDLNFQLRLSLKFKKTKTSIFLLTRLNLFEDAIDLALKN 699

  Fly   764 -LTFDMKLAKETASRPSDSKIRRKLWLRIAYH------DIKGTNDVKKAL-NLLKEC-DLLRIED 819
             |..|.|:.........|.|:|::|||:||.|      ||    |:|:.: .:|.:. ::|.|:|
Yeast   700 NLIDDCKVIVNDEILIEDYKLRKRLWLKIAKHLLLSMKDI----DIKQLIRTILNDSNEILTIKD 760

  Fly   820 LLPFFADFEKIDNFKEAICDALRDYNQRIQELQREMAETTEQTDRVTAELQQLRQHSLTVESQDT 884
            |||||.::..|.|.||.:...|.::|.::.|:..::..:......:..|:.:..:....:|...:
Yeast   761 LLPFFNEYTTIANLKEELIKFLENHNMKMNEISEDIINSKNLKVEINTEISKFNEIYRILEPGKS 825

  Fly   885 CEICEMMLLVKPFFIFICGHKFHSDCLEKHVVPLLTKEQCRRLGTLKQQLEAEVQTQAQPQSGAL 949
            |:.|...|.:|.|.:|.|||.||.:|:.:.::                            .|...
Yeast   826 CDECGKFLQIKKFIVFPCGHCFHWNCIIRVIL----------------------------NSNDY 862

  Fly   950 SKQQAME--LQRKRAALKTEIEDILAADCLFCG-LLISTIDQPF-VDDWE 995
            :.:|..|  |:.|......::|:|:...|..|. :.|:.||||. :|:.|
Yeast   863 NLRQKTENFLKAKSKHNLNDLENIIVEKCGLCSDININKIDQPISIDETE 912

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dor	NP_477286.2	Pep3_Vps18	311..464	CDD:461557	36/167 (22%)
		Clathrin	650..783	CDD:459884	30/154 (19%)
		RING_Ubox	883..981	CDD:473075	21/100 (21%)
PEP3	NP_013249.1	Pep3_Vps18	214..378	CDD:461557	36/166 (22%)
		CLH	585..737	CDD:128594	32/154 (21%)
		RING-H2_Pep3p-like	824..899	CDD:438125	21/102 (21%)