Protein Alignment dor and Vps18

DIOPT Version :10

• Sequence 1: NP_477286.2
• Gene: dor / 31118
• FlyBaseID: FBgn0000482
• Length: 1002
• Species: Drosophila melanogaster
• Sequence 2: NP_001099969.1
• Gene: Vps18 / 296083
• RGDID: 1311556
• Length: 973
• Species: Rattus norvegicus
• Alignment Length: 1009
• Identity: 345/1009 - (34%)
• Similarity: 533/1009 - (52%)
• Gaps: 86/1009 - (8%)

  Fly    19 SSGATANSYVATASGNPFETDDEDEIFSRHKMVLRVPSNCTGDLMHLAVSRNWLVCLLGTPERTT 83
            |.|...:.||..      ..:.|..||::.::........|.    |.||.:.|...||   :.|
  Rat    24 SVGIPHSGYVNA------HLEKEVPIFTKQRIDFTPSERITS----LVVSCSQLCMSLG---KDT 75

  Fly    84 LLRFFLPRAIPPGEAVLEKYLSGSGYKITRMFLDPTGHHIIIALVPKSATAGVSPDFLYIHCLES 148
            |||..|.:|..|....|.:   ....|:.:||||.||.|:::||        .|.:.||::
  Rat    76 LLRIDLGKASEPNRVELGR---KDDAKVHKMFLDHTGSHLLVAL--------SSTEVLYMN---- 125

  Fly   149 PQAQQLKVRRIEKFKDHEITAVAFNPYHGNESSTGPILLGTSRGLIFETELN--------PAADG 205
              ....|.|.:.::|...:.:|.:|...|:||||||||:||::|.|||.||:        ||.|
  Rat   126 --RNGQKARPLARWKGQLVESVGWNKALGSESSTGPILVGTAQGQIFEAELSASEGGLFGPAPD- 187

  Fly   206 HVQRKQLYDLGLGRPKYPITGLKLLRVPNSSRYIIVVTSPECIYTF--QETLKAEERSLQAIFAG 268
             :..:.||.|.......|:..|:..|.|: .|..::.|:.:.::.|  :....||.:....:||.
  Rat   188 -LYFRPLYVLNEEGGPAPVCSLEAERGPD-GRGFVIATTRQRLFQFIGRAVEDAEAQGFSGLFAA 250

  Fly   269 YVSGVQEPHCEERKTDLTFSQLRFFAPPNSKYPKQWAWLCGEGIRVGELSIEANSAATLIGNTLI 333
            |..  ..|...|...:|.:|:|.|:.|.....|:.:||:.|:|:..|  |::.....:|:....:
  Rat   251 YTD--HPPPFREFPGNLGYSELAFYTPKLRSAPRAFAWMMGDGVLYG--SLDCGRPDSLLSEEKV 311

  Fly   334 NLDFEKTMHLSYGERRLNTPKAFVLTEYHAVLLYADHVRAICLLNQEQVYQEAFDEARVGKPLSI 398
               :|....:..|   .|.|.|.|||::|.:||.||.|.|:|.|..:.|.::.|.| :.|....:
  Rat   312 ---WEYPAGIGPG---ANPPLAIVLTQFHFLLLLADRVEAVCTLTGQVVLRDHFLE-KFGPLRHM 369

  Fly   399 ERDELTGSIYVYTVKTVFNLRVTREERNVWRIYLDKGQYELATAHAAEDPEHLQLVLCQRADAAF 463
            .:|..||.::.||.:.||...|.||.|:|||.|||..:::||..:..|.|:.|..||.:.||..|
  Rat   370 VKDSSTGHLWAYTERAVFRYHVQREARDVWRTYLDMNRFDLAKEYCRERPDCLDTVLAREADFCF 434

  Fly   464 ADGSYQVAADYYAETDKSFEEVCLKFMVLPDKRPIINYVKKRLSRVTTKPMETDELDEDKMNIIK 528
            ....|..:|..||.|...|||:.|||:....:..:..:::::|:.:  ||.|..:        ..
  Rat   435 RQHRYLESARCYALTQSYFEEIALKFLEARQEEALAEFLQRKLAGL--KPTERTQ--------AT 489

  Fly   529 ALVIWLIDLYLIQINM----PDKDEEWRSSWQTEYDEFMMEAHVLSCTRQNRETVRQLIAEHADP 589
            .|..||.:|||.::..    ||....:|.:.:. :..|:...........:|.::.:|:|.|.|.
  Rat   490 LLTTWLTELYLSRLGALQGDPDALNLYRDTREC-FRTFLSSPRHKEWLFASRASIHELLASHGDT 553

  Fly   590 RNMAQFAIAIGDYDEVVAQQLKAECYAEALQTLINQRNPELFYKYAPELITRLPKPTVDALMAQG 654
            .:|..||:.:.||:.||....:.|.|.|||..|...|:|:||||::|.||..:|:..|||.:..|
  Rat   554 EHMVYFAVIMQDYERVVTYHCQHEAYEEALAVLARHRDPQLFYKFSPVLIRHIPRQLVDAWIEMG 618

  Fly   655 SRLEVEKLVPTLIIME---NREQREQTQRYLEFAIYKLNTTNDAIHNFLLHLYAEHEPKLLMKYL 716
            |||:..:|:|.|:...   :.:|..|..||:||.:..|..|..||||:||.|||..:|..|:.||
  Rat   619 SRLDARQLIPALVNYSQGGDAQQVSQAIRYMEFCVNVLGETEQAIHNYLLSLYARGQPASLLAYL 683

  Fly   717 EIQGRDESLVHYDIYYAHKVCTDLDVKEARVFLECMLRKWISAVDLALTFDMKLAKETASRP-SD 780
            |..|.....||||:.||.::|.:.....|.|.:..:|..:..||||||..|:.|||:.|..| .|
  Rat   684 EQAGASPHRVHYDLKYALRLCAEHGHHRACVHVYKVLELYEEAVDLALQVDVDLAKQCADLPEED 748

  Fly   781 SKIRRKLWLRIAYHDIKGTNDVKKALNLLKECDLLRIEDLLPFFADFEKIDNFKEAICDALRDYN 845
            .::|:||||:||.|.::...||:.|:..|..|.||:|||:||||.||..||:||||||.:|:.||
  Rat   749 EELRKKLWLKIARHVVQEEEDVQTAMACLASCPLLKIEDVLPFFPDFVTIDHFKEAICSSLKAYN 813

  Fly   846 QRIQELQREMAETTEQTDRVTAELQQLRQHSLTVESQDTCEICEMMLLVKPFFIFICGHKFHSDC 910
            ..||||||||.|.|....|:..:||:||....|||.||.|..|:..||.:||::|:|||.||:||
  Rat   814 HHIQELQREMEEATASAQRIRRDLQELRGRYGTVEPQDKCSTCDFPLLNRPFYLFLCGHMFHADC 878

  Fly   911 LEKHVVP-LLTKEQCRRLGTLKQQLEAEVQTQAQPQSGALSKQQ----AMELQRKRAALKTEIED 970
            |.:.|.| |.|.:|.|     .::|:.::.|...|..|::..::    |..:...|..||.::::
  Rat   879 LLQAVRPGLPTYKQAR-----LEELQRKLGTAPPPTKGSVKAKEAEAGAAAVGPSREQLKADLDE 938

  Fly   971 ILAADCLFCG-LLISTIDQPFVD--DWEQVNVEW 1001
            ::||:|::|| |:|.:||:||:|  .:|:.::.|
  Rat   939 LVAAECVYCGELMIRSIDRPFIDPQHYEEEHLSW 972

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dor	NP_477286.2	Pep3_Vps18	311..464	CDD:461557	51/152 (34%)
		Clathrin	650..783	CDD:459884	53/136 (39%)
		RING_Ubox	883..981	CDD:473075	35/103 (34%)
Vps18	NP_001099969.1	Pep3_Vps18	291..434	CDD:461557	51/151 (34%)
		Clathrin	615..743	CDD:459884	50/127 (39%)
		RING-H2_Vps18	851..949	CDD:438350	34/102 (33%)