Protein Alignment dor and pep3

DIOPT Version :10

• Sequence 1: NP_477286.2
• Gene: dor / 31118
• FlyBaseID: FBgn0000482
• Length: 1002
• Species: Drosophila melanogaster
• Sequence 2: NP_588498.1
• Gene: pep3 / 2539053
• PomBaseID: SPCC790.02
• Length: 900
• Species: Schizosaccharomyces pombe
• Alignment Length: 1041
• Identity: 243/1041 - (23%)
• Similarity: 424/1041 - (40%)
• Gaps: 209/1041 - (20%)

  Fly    15 IEHNS---SGATANSYVATASGNPFETDDEDEIFSRHKMVLRVPSNCTGDLMHLAVSRNWLVCLL 76
            |:.||   |....::.:...:.||  ..::..:||..|:.|:.|.:    :..|||..|.||..|
pombe     8 IDPNSSEDSDIQEDAELEYTADNP--EKEQRGVFSLEKVQLQFPVS----IRCLAVENNILVMAL 66

  Fly    77 GTPERTTLLRFFLPRAIPPGEAVLEKYLSGSGYKITRMFLDPTGHHIIIALVPKSATAGVSPDFL 141
             |.::..::....|..|...|...:....|..|||   ||||:||:|.:     :.|||
pombe    67 -TSDKLMIVDLERPEDIIDIELPKKVLALGLTYKI---FLDPSGHYIFV-----TTTAG------ 116

  Fly   142 YIHCLESPQAQQLKVRRIEKFKDHEITAVAFNPYHGNESSTGPILLGTSRGLIFE--TELNPAAD 204
             .:||.:|..|.   |.:.|.|.|.:.||.:|...||...   :|:.:..|::.|  ..|:.|..
pombe   117 -DNCLFTPSHQG---RVLTKLKGHTVEAVQWNLNGGNILE---LLIASKSGVLLELVLTLDSANL 174

  Fly   205 GHVQR--KQLYDLGLGRPKYP-------------------ITGLKLLRV-PNSSRYIIVVTSPEC 247
            ..:::  ..||       .:|                   :|..::||. |.:||      ..:.
pombe   175 KRIEKSINTLY-------SFPFMESPMGILKNIQDDSMTIVTNKRILRFEPKTSR------GKDQ 226

  Fly   248 IY---TFQETLK-----AEERSLQAI-FAGYVSGVQEPHCEERKTDLTFSQLRFFAPPNSKYPKQ 303
            :|   .||.::|     :||.:.|.. ::.:...:.||:....||......|....|.|.
pombe   227 LYFSPAFQGSMKEILSFSEEETAQCFSYSPFPKNLAEPYTLALKTSKRIIYLDIMNPVNP----- 286

  Fly   304 WAWLCGEGIRVGELSIEANSAATLIGNTLINLDFEKTMHLSYGERRLNTPKAFVLTEYHAVLLYA 368
                                       .:.:.:|.::..||.....:|    .:||.:|...|..
pombe   287 ---------------------------DIQDYEFNESPKLSVPTVEMN----MILTSFHLAFLDL 320

  Fly   369 DHVRAICLLNQEQVYQEAFDEARVGKPLSIERDELTGSIYVYTVKTVFNLRVTREERNVWRIYLD 433
            |.:..:..:|.::.||:..:.:...:.|.:..|....:.::||..::..|.|..|.|....::|:
pombe   321 DTLYIVNRVNGKESYQQRVNLSPHEEILGLCCDHEKNTYWLYTTDSLHELVVNNETREASLVFLE 385

  Fly   434 KGQYELATAHAAEDPEHLQLVLCQRADAAFADGSYQVAADYYAETDKSFEEVCLKFMVLPDKRPI 498
            ||.:|.| ...|...:....||...|:.......|:.||..||||.||.|||.|||:.|..|..:
pombe   386 KGDFEKA-LECANTAKVRNTVLVGYAEFLMEHEEYERAATLYAETLKSVEEVALKFIELNQKDVL 449

  Fly   499 INYVKKRLSRVTTKPMETDELDEDKMNIIKALVI-WLIDLYLIQINMPDKDE----------EWR 552
            ..|:.|:|...           :..|.|.|:|:: ||::|.|.::|..|:.|          :.|
pombe   450 RLYLWKKLRSY-----------KSTMKIQKSLLVNWLLELMLAKLNSLDEKERLELFPENVMQQR 503

  Fly   553 SSWQTEYDEFMMEAHVLSCTRQNRETVRQLIAEHADPRNMAQFAIAIGDYDEVVAQQLKAECYAE 617
            ...|.|:...:.:..    ...|||....|...:.....:.|.|..:.|...::...::.|.|.:
pombe   504 QQVQREFSTLLNQYK----DEINREAAYNLANNYGKEEQLLQIATVMKDQSYIMHYWVQRENYEK 564

  Fly   618 ALQTLINQRNPELFYKYAPELITRLPKPTVDALMAQGSRLEVEKLVPTLIIMENRE----QREQT 678
            ||:||....:.|...::|..|:|..|..|| ::..:.:.|:|..|:|:|:....|.    :....
pombe   565 ALETLNEGVSQETLIQHATALLTHRPNETV-SIWERQTDLDVHALIPSLLSYNQRSHVPVEENAA 628

  Fly   679 QRYLEFAIYKLNTTNDAIHNFLLHLYAEH---EPKLLMKYLEIQGRDESLVH--YDIYYAHKVCT 738
            .|||.:....|...:.:|||.|..:||.|   ....||.|:|.||.     |  ||:....::|.
pombe   629 IRYLRYVTGVLGCVDPSIHNTLFCIYACHSSSNESYLMNYIEQQGN-----HPLYDMDLGIRLCL 688

  Fly   739 DLDVKEARVFLECMLRKWISAVDLAL-TFDMKLAKETASRPSDSKIRRK-LWLRIAYHDIKGTND 801
            ..:.:.:.|.:..:::.:...|:||| ..|.:||...|:.|.:..:.:| ||..||.:.....:.
pombe   689 QFNCRRSAVKILVLMKLYSQGVELALEADDCELAATIANIPEEDVVLKKTLWQTIAKYMFSKKSG 753

  Fly   802 VKKALNLLKECDLLRIEDLLPFFADFEKIDNFKEAICDALRDYNQRIQELQREMAETTEQTDRVT 866
            :|:.|..|:..::|::.:|:....:..|:|:..:.:||.|....:||::|..|:.:.:|....:.
pombe   754 IKETLRFLENSEVLQLPELIRLLPEDIKLDDLSDNVCDELDHCMKRIEQLDFEIGQASEVAHEIQ 818

  Fly   867 AELQQLRQHSLTVESQDTCEICEMMLLVKPFFIFICGHKFHSDC-LEKHVVPLLTKEQCRRLGTL 930
            ...:.:|...:.:|..::|..|...|..:||.:|.|.|.||..| |||
pombe   819 TNAENMRNRYIVLEPNESCWHCNQPLFSEPFVLFPCQHAFHRSCMLEK----------------- 866

  Fly   931 KQQLEAEVQTQAQPQSGALSKQQAMELQRKRAALKTEIEDILAADCLFCG--LLISTIDQPFVDD 993
                                   ..:|..::..||         :|..||  ..:..|::||..|
pombe   867 -----------------------TYKLASEKNILK---------ECQLCGPSYAVRLINEPFSTD 899

  Fly   994 W 994
            :
pombe   900 F 900

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dor	NP_477286.2	Pep3_Vps18	311..464	CDD:461557	29/152 (19%)
		Clathrin	650..783	CDD:459884	37/142 (26%)
		RING_Ubox	883..981	CDD:473075	20/100 (20%)
pep3	NP_588498.1	Pep3_Vps18	282..415	CDD:461557	31/169 (18%)
		RING-H2_Pep3p-like	835..887	CDD:438125	20/100 (20%)