Protein Alignment dor and vps-18

DIOPT Version :10

• Sequence 1: NP_477286.2
• Gene: dor / 31118
• FlyBaseID: FBgn0000482
• Length: 1002
• Species: Drosophila melanogaster
• Sequence 2: NP_494788.3
• Gene: vps-18 / 173783
• WormBaseID: WBGene00021058
• Length: 1026
• Species: Caenorhabditis elegans
• Alignment Length: 1033
• Identity: 285/1033 - (27%)
• Similarity: 464/1033 - (44%)
• Gaps: 181/1033 - (17%)

  Fly    92 AIPPGE---AVLEK----YLSGSGYK-------------ITRMFLDPTGHHIIIALVPKSATAGV 136
            |:..||   ||.||    |..|:|.:             :..:.|..||.|.|:     |:..|.
 Worm    36 AVQNGEMLAAVTEKLLVHYSEGTGERHQEMSLPLNGPDHVAYIHLSRTGFHAIV-----SSKLGH 95

  Fly   137 SPDFLYIHCLESPQAQQLKVRRIEKFKDHEITAVAFNPYHGNES-STGPILLGTSRGLIFETELN 200
            :   .||| |:|.....||..|.      .:|||.:||.:..|: :||||||||::|.|.  |||
 Worm    96 N---FYIH-LKSNAFHHLKKLRC------VVTAVGWNPDYSKETDTTGPILLGTAQGSII--ELN 148

  Fly   201 PAADGHVQ-----RKQLYDLGLGR------PKYPITGLKLLR--------------VPNSSRYII 240
            ..:.|.:.     ..|:..:...|      |...||.::|.:              :...:|.|:
 Worm   149 VGSTGMMTTLKELTSQVAQIAEQRITSAPSPAAAITDIQLFQLADDDPKNKKWMVIIAQMARLIV 213

  Fly   241 VVTSPECI-------YTFQETLKAEERSLQAIFAGYVSGVQEPHCEERKTDLTFSQLRFFAPPN- 297
            ::|..|..       :|...:|:|...:|               ..|:....||..  ||..||
 Worm   214 LITDNEPAPVVKLGGFTSSASLQAGLMNL---------------ATEQAPSTTFHS--FFTSPNT 261

  Fly   298 -------SKY------------------PKQWAWLCGEGIRVGELSIEANSAATLIGNTLINLDF 337
                   ||:                  ||::|||..:||.:|.::|.|..    |.:.|:. :|
 Worm   262 LQHTISSSKFSEKFKNHGFLTMHPTIAEPKRYAWLSPDGISIGNVNIYAER----IQDVLVE-EF 321

  Fly   338 EKTMHLSYGERRLNTPKAFVLTEYHAVLLYADHVRAICLLNQEQVYQEAFDEARVGKPLSIERDE 402
            .....|..|  ||..|....||:||.:|.|:..|.|:.||....|..|......:|..|....|.
 Worm   322 NIEHRLIEG--RLEPPTGIALTDYHVLLAYSSRVLALSLLPPHDVIFEDPWNPELGGALGFVSDN 384

  Fly   403 LTGSIYVYTVKTVFNLRVTREERNVWRIYLDKGQY----ELATAHAAEDPEHLQLVLCQRADAAF 463
            :...:::||...........|.|.:|:.|||:|:|    ::|....|.:|:.|::||.::||...
 Worm   385 VAEFVWLYTQTFAMKYGTNDEARYIWKTYLDRGEYQKALQIARTRVAIEPDALEMVLRKQADFYI 449

  Fly   464 ADGSYQVAADYYAETDKSFEEVCLKFMVLPDKRPIINYVKKRLSRVTTKPMETDELDEDKMNIIK 528
            .:.::..||:..|::.:.||.|.|||:....:|      |..|..:..|.:|.....|||:. ..
 Worm   450 QEKNFTAAAEILAQSSEPFESVVLKFLTNSSER------KMGLKTLLDKKLERLTRHEDKIR-RD 507

  Fly   529 ALVIWLIDLYLIQI--------NMPDKD--EEWRSSWQTEY-DEFMMEAHVLSCTRQNRETVRQL 582
            |||:||:::.|.::        :.||..  |:.|.:  |:: ..:.|..:|:...:.||:.|.::
 Worm   508 ALVMWLLNVQLEELAEMRRLKNSNPDPAFVEKLRDT--TDHVQRYFMRKNVIESIQTNRDAVYRM 570

  Fly   583 IAEHADPRNMAQFAIAIGDYDEVVAQQLKAECYAEALQTLINQRNPELFYKYAPELITRLPKPTV 647
            ...|||......||.|:.|...|:...:..|.|.|.|:.|.|||..||.|:..|.||..:||..:
 Worm   571 CVAHADFEMQLFFANAVKDLRTVIDILMLREQYFEVLEVLKNQRISELTYEMCPLLIEHIPKQVI 635

  Fly   648 DALMAQGSRLEVEKLVPTL-IIMENREQREQTQRYLEFAIYK------LNTTNDA-IHNFLLHLY 704
            ..|:....::..:||.|.| :.::|.|......:||| |.:|      .|..|.| :||..:||.
 Worm   636 VYLIQNQDQISPQKLTPCLSLCVKNMEMAIPAIKYLE-AQFKGTQTISQNPQNLANLHNIYIHLM 699

  Fly   705 AEHEPKLLMKYLEIQGRDESLVHYDIYYAHKVCTDLDVKEARVFLECMLRKWISAVDLALTFDMK 769
            |:...:.|:.|||..|...|.:.|::.:|.:.|....::...|:|.|:...:..||:.||.||:.
 Worm   700 AKFRREKLLGYLESHGTIRSDLPYELDFAMRTCEQFKIEPCVVYLFCVAGMFGDAVEKALGFDVD 764

  Fly   770 LAKETA-------------------------SRPSDSKIRRKLWLRIAYHDIKGTNDVKKALNLL 809
            |||:.|                         .:..|.|.::.:||:|..:.:...|:|.|.:.|:
 Worm   765 LAKKCALMMEEAEANFAWLEGMEDPAATSYIRQKLDEKAKKAIWLKIGQYYVTQENNVDKCIELI 829

  Fly   810 KECD-LLRIEDLLPFFADFEKIDNFKEAICDALRDYNQRIQELQREMAETTEQTDRVTAELQQLR 873
            .|.: ||.|:||||....|.::...|..|.|.|:...||:::|:|.|.|.||....:..:.::|:
 Worm   830 NESNHLLTIQDLLPIIPKFTRVGALKPIIVDFLKRNKQRLEKLERSMKEATEIASEIRDKQEKLK 894

  Fly   874 QHSLTVESQDTCEICEMMLLVKPFFIFICGHKFHSDCLEKHVVPLLTKEQCRRLGTLKQQLEAEV 938
            ..:..|:..|.|..|...:..:.|.:..|.|.||.:|||..::..|::|:..::.||... |..|
 Worm   895 NRTTVVKPSDVCSHCARPISGRAFNVHSCRHFFHRECLEIAMISFLSQEEVEKMKTLIID-EERV 958

  Fly   939 QTQAQPQSGALSKQQAMELQRKRAALKTEIEDILAADCLFCG-LLISTIDQPFVDDWE 995
            .:|.:.:..|.:::..:|.|.|...:...|.:|:.|:|..|| :.||.||:.|:.|.|
 Worm   959 LSQMKAEQLAGNQKGFIEKQEKYLKIAAFISNIVGAECPLCGNIAISQIDKQFLSDEE 1016

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dor	NP_477286.2	Pep3_Vps18	311..464	CDD:461557	46/156 (29%)
		Clathrin	650..783	CDD:459884	43/165 (26%)
		RING_Ubox	883..981	CDD:473075	28/98 (29%)
vps-18	NP_494788.3	Pep3_Vps18	300..450	CDD:461557	46/156 (29%)
		RING_Ubox	906..1004	CDD:473075	27/98 (28%)