DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14785 and KLHL31

DIOPT Version :9

Sequence 1:	NP_569912.2	Gene:	CG14785 / 31094	FlyBaseID:	FBgn0027795	Length:	470	Species:	Drosophila melanogaster
Sequence 2:	NP_001003760.2	Gene:	KLHL31 / 401265	HGNCID:	21353	Length:	634	Species:	Homo sapiens

Alignment Length:	183	Identity:	38/183 - (20%)
Similarity:	62/183 - (33%)	Gaps:	44/183 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   275 FLCIVGSPFFLYFTEHELTHILRNCYLSVNSEIEIFLSVVLWLEHNWLERGDCAERILAEVHFAL 339
            ||....|..|:..|..::..:|.:..|.:.|||..|...:.|||.: .:|...|..:|:.:.|..
Human   199 FLEFAESDQFMKLTFEQINELLIDDDLQLPSEIVAFQIAMKWLEFD-QKRVKYAADLLSNIRFGT 262

  Fly   340 MPTWYLCTLDRSNRCNHFARVIHSPGVQRL-----------------------IAAGLEDAITLK 381
                 :...|..|......|::......||                       |..|....:|:.
Human   263 -----ISAQDLVNYVQSVPRMMQDADCHRLLVDAMNYHLLPYHQNTLQSRRTRIRGGCRVLVTVG 322

  Fly   382 SKPRFSGAALHRQRKHQEERLLVRD----WIVDTECSHHHKSHC----EQFVY 426
            .:|..:..:|.|.       :|.||    |...||......:.|    :.|:|
Human   323 GRPGLTEKSLSRD-------ILYRDPENGWSKLTEMPAKSFNQCVAVMDGFLY 368

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14785	NP_569912.2	BACK	256..345	CDD:197943	18/69 (26%)
CG14785	NP_569912.2	DUF4734	360..450	CDD:292506	17/98 (17%)
KLHL31	NP_001003760.2	BTB	63..164	CDD:279045
		PHA03098	73..601	CDD:222983	38/183 (21%)
		BACK	172..273	CDD:285009	20/79 (25%)
		Kelch 1	317..365		11/54 (20%)
		KELCH repeat	356..405	CDD:276965	3/13 (23%)
		Kelch 2	366..419		2/3 (67%)
		Kelch	367..419	CDD:128874	1/2 (50%)
		KELCH repeat	409..453	CDD:276965
		Kelch	420..466	CDD:128874
		Kelch 3	420..466
		Kelch_1	455..500	CDD:279660
		KELCH repeat	456..501	CDD:276965
		Kelch 4	468..513
		Kelch_1	502..552	CDD:279660
		KELCH repeat	503..551	CDD:276965
		Kelch 5	515..565
		KELCH repeat	555..602	CDD:276965
		Kelch 6	567..614
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910