DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11417 and Esf1

DIOPT Version :9

Sequence 1:	NP_569906.1	Gene:	CG11417 / 31083	FlyBaseID:	FBgn0024364	Length:	771	Species:	Drosophila melanogaster
Sequence 2:	NP_001074559.1	Gene:	Esf1 / 66580	MGIID:	1913830	Length:	845	Species:	Mus musculus

Alignment Length:	902	Identity:	310/902 - (34%)
Similarity:	449/902 - (49%)	Gaps:	232/902 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 SENGIWQDSRFQHLLTDPRFRGVPKVQRKVKIDKRFQGMFTDDKFKVKYTVDKYGRPVNKSNAED 101
            |:..|..|.||:.:..||||..:|:.:|||||||||:.||.|.|||:.|.|||.|||::.|..||
Mouse     3 SKQEIMDDQRFRRVSKDPRFWEMPEKERKVKIDKRFRAMFHDKKFKLNYAVDKRGRPISHSTTED 67

  Fly   102 LRKFYELDENESSSGEEPAK-------KESDLDSEAEAEQQERRAEERAIANLEKEESNDTLESD 159
            |::||:|.:::|...:|.:|       |:....::.||:..|:..||:      |:|:..|.:.|
Mouse    68 LKRFYDLSDSDSDLSDEESKILSQKKAKQKKKQTKKEAKSIEKPIEEK------KKETKKTDQKD 126

  Fly   160 S--------SEVSQSLRQRLTNPEID-----------------YARG----------EGRLYT-D 188
            |        ||..|.::......:||                 ..||          :|:|.| |
Mouse   127 SINKHDLNNSERVQKMKNSQKPQKIDSEISPKKDNEEFLQNKKKKRGTTDLSVEALPKGKLRTKD 191

  Fly   189 SS----------------------------------------------------SDEDSDDE--- 198
            ||                                                    |||:|:||
Mouse   192 SSTSEMVKSSTMSSSKAKREKQSVVPVIMAKDNDGKMPDEDALEEDSDSASELGSDEESEDEIIS 256

  Fly   199 ----------------------------------DEGPELQ------------------------ 205
                                              |.||:|.
Mouse   257 DGKTSADEDESEEEDEEEEEDSEEEEEEEEEDESDSGPDLARGKGNVETSSEDEDDLADLFPEEP 321

  Fly   206 -IDHVWGELDNDAEHTEESTRRLAVCNMDWDRIRAEDLMVMLSSFLPPGGSILSVKIYPSEFGKA 269
             .:|.|.|||.||...:|.|||||||||||||::|:||:.:.:||.|.||.:.|||||||||||.
Mouse   322 GFEHAWRELDKDAPRADEITRRLAVCNMDWDRLKAKDLLALFNSFKPKGGVVFSVKIYPSEFGKE 386

  Fly   270 RMAEEEVHGPKELVERVEPEDDSDEELVRQQDSDAEEGEDYHMEKLRQYQLNRLRYYYAVVECDS 334
            ||.||:|.||.||:...|               ||.|.:....||||.||..||:|||||.||||
Mouse   387 RMKEEQVQGPVELLSIPE---------------DAPEKDWASREKLRDYQFKRLKYYYAVAECDS 436

  Fly   335 IDTADKVYKECDGIEYESSATRVDLRFIPDDTSFEEDTPSDECFELPDASSYKPRQFTTTALQQA 399
            .:||.|:|::|||:|:|||.:.:||||||||.:| :|.|.|...|: |.::|||:.||:.|:..:
Mouse   437 PETASKIYEDCDGLEFESSCSFIDLRFIPDDITF-DDEPKDVALEV-DLTAYKPKYFTSAAMGTS 499

  Fly   400 KVDLTWDETALDR-RELGDKLSSGQVDKLTDKELRQIVAYSSEEEDSEAEESP-AEEAAQKAVSE 462
            .|::|||||..:| ..|..|...   |:|.|.:.:..:|.|||:|: |.||:| .||...  :.|
Mouse   500 TVEITWDETDHERITTLNRKFKK---DELLDMDFQAYLASSSEDEE-EVEEAPEGEEGVN--IGE 558

  Fly   463 DPQKSKPKKTSK--QERIATYKNLLADILEQEKKEKEQKYEMEMTW---NVEPQHEEAQPEQQAQ 522
            |   .|.||:.|  :|:||.|:.||..|.|:|||.||...|||:.|   ..|...|..:.:.:.:
Mouse   559 D---GKTKKSQKDDEEQIAKYRQLLQVIQEKEKKGKENDMEMEIKWVPGLKESAEEMVKNKLEGK 620

  Fly   523 AELTPIEKVIQKRSEKNRQRKEQRRQRQIEARGGDAGEDSDESMVPDGIDLNDAYFAEEFANGDY 587
            .:|||.|:.::|:.||.|.:|:|:..         |.|||::.: |..:|.||.|||||.
Mouse   621 DKLTPWEQFLEKKKEKKRLKKKQKAL---------AEEDSEDEL-PSDVDFNDPYFAEEV----- 670

  Fly   588 APPKTKQDKKKKKKKGKD--DGEEDVEAKRQEKELELLLDDGDGRDEKQHFSLTKILKKEEQEAS 650
               |....|||..|..||  ..||:.:.::|:.|:.||:.| :..|.|:||:..||::.:..
Mouse   671 ---KKIGIKKKSMKSAKDSASSEEETDLEKQKAEMALLVMD-EEEDSKKHFNYDKIVEHQNL--- 728

  Fly   651 GSKRKRRQKLKKSKNQPQNAEKLDDDFQVNLNDNRFSAVYKSHEYNIDPTHSHYKPTKGMQQIIG 715
             ||:|::|.:||.       |.::|||:||::|.||.|:|.||.:|:||:..::|.||.|::|:.
Mouse   729 -SKKKKKQLMKKK-------ELVEDDFEVNVSDARFQAMYTSHLFNLDPSDPNFKKTKAMEKILE 785

  Fly   716 EKLKRRKEQGEGGAANGDADGDEQVAPKRSKQQLEQ--NALVKSLKRKIQLQQQGQK 770
            || .|.:|:.|...........:.......||.::.  :.|:||:|.|.: |.|.:|
Mouse   786 EK-ARHRERKEELLIQAVERAQQDTGKPTQKQPMDPALSMLIKSVKNKTE-QFQARK 840

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11417	NP_569906.1	COG5638	44..763	CDD:227925	305/886 (34%)
CG11417	NP_569906.1	NUC153	683..711	CDD:285385	13/27 (48%)
Esf1	NP_001074559.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	54..321		49/272 (18%)
		COG5638	295..798	CDD:227925	225/559 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	536..570		16/39 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	634..660		10/35 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	676..696		8/19 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847828
Domainoid	1	1.000	358	1.000	Domainoid score	I961
eggNOG	1	0.900	-	-		E1_COG5638
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5717
Inparanoid	1	1.050	402	1.000	Inparanoid score	I1909
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53646
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004705
OrthoInspector	1	1.000	-	-		oto93589
orthoMCL	1	0.900	-	-		OOG6_103088
Panther	1	1.100	-	-	LDO	PTHR12202
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R416
SonicParanoid	1	1.000	-	-		X3307
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.790