Protein Alignment CG11417 and ESF1

DIOPT Version :10

• Sequence 1: NP_569906.1
• Gene: CG11417 / 31083
• FlyBaseID: FBgn0024364
• Length: 771
• Species: Drosophila melanogaster
• Sequence 2: NP_057733.2
• Gene: ESF1 / 51575
• HGNCID: 15898
• Length: 851
• Species: Homo sapiens
• Alignment Length: 918
• Identity: 307/918 - (33%)
• Similarity: 448/918 - (48%)
• Gaps: 258/918 - (28%)

  Fly    37 SENGIWQDSRFQHLLTDPRFRGVPKVQRKVKIDKRFQGMFTDDKFKVKYTVDKYGRPVNKSNAED 101
            |:..|..|.||:.:..||||..:|:..|||||||||:.||.|.|||:.|.|||.|||::.|..||
Human     3 SKQEIMSDQRFRRVAKDPRFWEMPEKDRKVKIDKRFRAMFHDKKFKLNYAVDKRGRPISHSTTED 67

  Fly   102 LRKFYELDENESS-SGEE--------------PAKKESDLDSEAEAEQQERRAEERAIANL---- 147
            |::||:|.:::|: |||:              ..|||.|..:..|.:::.::|..:...|.
Human    68 LKRFYDLSDSDSNLSGEDSKALSQKKIKKKKTQTKKEIDSKNLVEKKKETKKANHKGSENKTDLD 132

  Fly   148 ---------------------------------EKEESN-------------------------- 153
                                             :||:.|
Human   133 NSIGIKKMKTSCKFKIDSNISPKKDSKEFTQKNKKEKKNIVQHTTDSSLEEKQRTLDSGTSEIVK 197

  Fly   154 ---------------------------------------DTLESDSSEVSQSLRQRLTNPEI--- 176
                                                   |.||.||..||:......:..||
Human   198 SPRIECSKTRREMQSVVQLIMTRDSDGYENSTDGEMCDKDALEEDSESVSEIGSDEESENEITSV 262

  Fly   177 --------------------------------------DYARGEGRLYTDSSSDEDSDD---EDE 200
                                                  |.|||:|.:.|.|..::|:.|   |:.
Human   263 GRASGDDDGSEDDEEEDEDEEEDEDEDSEDDDKSDSGPDLARGKGNIETSSEDEDDTADLFPEES 327

  Fly   201 GPELQIDHVWGELDNDAEHTEESTRRLAVCNMDWDRIRAEDLMVMLSSFLPPGGSILSVKIYPSE 265
            |    .:|.|.|||.||...:|.|||||||||||||::|:||:.:.:||.|.||.|.||||||||
Human   328 G----FEHAWRELDKDAPRADEITRRLAVCNMDWDRLKAKDLLALFNSFKPKGGVIFSVKIYPSE 388

  Fly   266 FGKARMAEEEVHGPKELVERVEPEDDSDEELVRQQDSDAEEGEDYHMEKLRQYQLNRLRYYYAVV 330
            |||.||.||:|.||.||:...|               ||.|.:....||||.||..||:||||||
Human   389 FGKERMKEEQVQGPVELLSIPE---------------DAPEKDWTSREKLRDYQFKRLKYYYAVV 438

  Fly   331 ECDSIDTADKVYKECDGIEYESSATRVDLRFIPDDTSFEEDTPSDECFELPDASSYKPRQFTTTA 395
            :|||.:||.|:|::|||:|:|||.:.:||||||||.:| :|.|.|...|: :.::|||:.||:.|
Human   439 DCDSPETASKIYEDCDGLEFESSCSFIDLRFIPDDITF-DDEPKDVASEV-NLTAYKPKYFTSAA 501

  Fly   396 LQQAKVDLTWDETALDR-RELGDKLSSGQVDKLTDKELRQIVAYSSEEEDSEAEESPAEEAAQKA 459
            :..:.|::|||||..:| ..|..|...   ::|.|.:.:..:|.|||:|:...||...::...
Human   502 MGTSTVEITWDETDHERITMLNRKFKK---EELLDMDFQAYLASSSEDEEEIEEELQGDDGVN-- 561

  Fly   460 VSEDPQKSKPKKTSK--QERIATYKNLLADILEQEKKEKEQKYEMEMTW---NVEPQHEEAQPEQ 519
            |.||   .|.||:.|  :|:||.|:.||..|.|:|||.||...|||:.|   ..|...|..:.:.
Human   562 VEED---GKTKKSQKDDEEQIAKYRQLLQVIQEKEKKGKENDMEMEIKWVPGLKESAEEMVKNKL 623

  Fly   520 QAQAELTPIEKVIQKRSEKNRQRKEQRRQRQIEARGGDAGEDSDESMVPDGIDLNDAYFAEEFAN 584
            :.:.:|||.|:.::|:.||.|.:::|:.          ..|::.|..:|..:||||.|||||
Human   624 EGKDKLTPWEQFLEKKKEKKRLKRKQKA----------LAEEASEEELPSDVDLNDPYFAEE--- 675

  Fly   585 GDYAPPKTKQ--DKKKKKKKGKD--DGEEDVEAKRQEKELELLLDDGDGRDEKQHFSLTKILKKE 645
                   .||  ..||..|..||  ..||::|.:||:.|:.||:.|.| .|.|:||:..||::.:
Human   676 -------VKQIGINKKSVKSAKDGTSPEEEIEIERQKAEMALLMMDED-EDSKKHFNYNKIVEHQ 732

  Fly   646 EQEASGSKRKRRQKLKKSKNQPQNAEKLDDDFQVNLNDNRFSAVYKSHEYNIDPTHSHYKPTKGM 710
            ..    ||:|::|.:||.       |.::|||:||:||.||.|:|.||.:|:||:..::|.||.|
Human   733 NL----SKKKKKQLMKKK-------ELIEDDFEVNVNDARFQAMYTSHLFNLDPSDPNFKKTKAM 786

  Fly   711 QQIIGEKLKR--RKEQGEGGAANGDADGDEQVAPKRSKQQLEQNA-----------LVKSLKRKI 762
            ::|:.||.::  ||||            :...|.|:.:.::|:.:           |:||:|.|.
Human   787 EKILEEKARQRERKEQ------------ELTQAIKKKESEIEKESQRKSIDPALSMLIKSIKTKT 839

  Fly   763 QLQQQGQK 770
            : |.|.:|
Human   840 E-QFQARK 846

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG11417	NP_569906.1	COG5638	44..763	CDD:227925	302/902 (33%)
ESF1	NP_057733.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	74..134		12/59 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	148..328		22/179 (12%)
		COG5638	301..836	CDD:227925	240/607 (40%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	542..576		13/38 (34%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	640..667		7/36 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	794..827		7/44 (16%)