Protein Alignment CG11403 and CHL1

DIOPT Version :9

• Sequence 1: NP_569898.1
• Gene: CG11403 / 31072
• FlyBaseID: FBgn0026876
• Length: 861
• Species: Drosophila melanogaster
• Sequence 2: NP_015317.1
• Gene: CHL1 / 856099
• SGDID: S000005929
• Length: 861
• Species: Saccharomyces cerevisiae
• Alignment Length: 952
• Identity: 297/952 - (31%)
• Similarity: 462/952 - (48%)
• Gaps: 207/952 - (21%)

  Fly    15 AQEFGFPYSPYEIQEQLMQELFQVLERG-QVGIFESPTGTGKSLTLTCGALTWLARHEELVRTEM 78
            ::.|..||.||:||.|||:.:::||..| ::.|.||||||||:|:|.|..:|||..::..:.|.|
Yeast     7 SETFYHPYKPYDIQVQLMETVYRVLSEGKKIAILESPTGTGKTLSLICATMTWLRMNKADIFTRM 71

  Fly    79 LARIRGVEQELAKLKEESEQSSNW-LESQGKSRAQ-RAELLR--LQHLQAL-------------L 126
            ...|:..|.:...|   |:...:| :::..||..| :.:||.  .:||..:             |
Yeast    72 ETNIKTNEDDSENL---SDDEPDWVIDTYRKSVLQEKVDLLNDYEKHLNEINTTSCKQLKTMCDL 133

  Fly   127 DKQE---QQLDQIRKGAKKHKRQGRVH-PGKLEELEKDLDP---ESDSDSEHET--------ADG 176
            ||:.   :.:|.:||     ||:|..| ...||  |:|..|   ||||::...:        :|.
Yeast   134 DKEHGRYKSVDPLRK-----KRKGARHLDVSLE--EQDFIPRPYESDSENNDTSKSTRGGRISDK 191

  Fly   177 PQEAAE-----------------------DRY-----RPVQIFFCSRTHSQLAQIVAELR----- 208
            ..:.:|                       ||:     .||:|::.|||:|||.|..::||
Yeast   192 DYKLSELNSQIITLLDKIDGKVSRDPNNGDRFDVTNQNPVKIYYASRTYSQLGQFTSQLRLPSFP 256

  Fly   209 -----KTPHGQSVRSISLGSRQQLCGNPAVRKLKHVGLMNERCLDMATKKARPNPSKKSRLTAEA 268
                 |.| .:.|:.:.|.|::|||.||.|.|.|.:..:|:.|.|:       ..||:..:..:.
Yeast   257 SSFRDKVP-DEKVKYLPLASKKQLCINPKVMKWKTLEAINDACADL-------RHSKEGCIFYQN 313

  Fly   269 NS---RCPFKAASLVESLRDLALTEPLDIEELANEGTACGGCSYYASRSAVEHAQLILLPYQLLL 330
            .:   .||...|     |||:..:|..|||:|...|.:.|.|.|||||.|:..|:::.||||.||
Yeast   314 TNEWRHCPDTLA-----LRDMIFSEIQDIEDLVPLGKSLGICPYYASREALPIAEVVTLPYQYLL 373

  Fly   331 QKSARNQLGISLKGSIVIVDEAHNLLDSVAQLHGSEISRQQLERAKVQISGYKDHFQKRF---TT 392
            .:|.|:.|.|:|:.||||:||||||::::..::.|:||.:.|:.....|..|.:.|:.|.   ..
Yeast   374 SESTRSSLQINLENSIVIIDEAHNLIETINSIYSSQISLEDLKNCHKGIVTYFNKFKSRLNPGNR 438

  Fly   393 KNLLKINQII-----FIIRRLLKILDQRKELQSNGCSMMRTYELTAEGDFF---NID---LCELL 446
            .||||:|.::     ||::...||   .:|:..|              |.|   |||   :.:||
Yeast   439 VNLLKLNSLLMTLIQFIVKNFKKI---GQEIDPN--------------DMFTGSNIDTLNIHKLL 486

  Fly   447 DFCARTRFARKVQGRADRMEREPRPSENQAPVSTARSLILQRLASEQKLKEKTKSVKRRVEDINK 511
            .:...::.|.|:.            :.|||                  |||
Yeast   487 RYIKVSKIAYKID------------TYNQA------------------LKE-------------- 507

  Fly   512 EDKAEELQEQQKPTKKPVEEVAPSPIRPLL----AFLETLTSNAEDGRILVDPVGGTLKYILLDP 572
                ||..:.:.|.|:..::...|  :|||    .||..||:...:|:...:. ..::||:||:|
Yeast   508 ----EESSKNENPIKETHKKSVSS--QPLLFKVSQFLYCLTNLTSEGQFFFEK-NYSIKYMLLEP 565

  Fly   573 AEQFADIVAEARAIVIAGGTMQPTKELKEQLFTGC-HDRLVERFYNHVVANDAILPFVISNGPSG 636
            ::.|..|:.:|:.:|:|||||:|..|....|.... .:.:.....|||:..:.:..: |:|.|.
Yeast   566 SKPFESILNQAKCVVLAGGTMEPMSEFLSNLLPEVPSEDITTLSCNHVIPKENLQTY-ITNQPE- 628

  Fly   637 APLSFKFAHRGSAEML-RELSMILRNLCQVVP--GGVVCFLPSYEYLDKVYKYLEQSGTLETISG 698
              |.|.|..|.|..:: ..|.....:|.:.||  ||:|.|.|||:||..|.:..:|:....|::.
Yeast   629 --LEFTFEKRMSPSLVNNHLFQFFVDLSKAVPKKGGIVAFFPSYQYLAHVIQCWKQNDRFATLNN 691

  Fly   699 RKSVFREVSGSAEQLLDNYALAIKRPASYGALLLSVVGGKLSEGLNFADDLGRAVLVVGLPYSNS 763
            .:.:|.|.. ..:.:|..|:.::..  ..|:|||::||||||||:||.|||.|||::||||:.|.
Yeast   692 VRKIFYEAK-DGDDILSGYSDSVAE--GRGSLLLAIVGGKLSEGINFQDDLCRAVVMVGLPFPNI 753

  Fly   764 LSPELRQRMQHLDEKLGPGAG---------NEYYENLCVKAVNQCIGRAVRHIKDYACVYLLDKR 819
            .|.||..:.:||..|:....|         .|:.||:|:|||||.:|||:||..|||.:||||.|
Yeast   754 FSGELIVKRKHLAAKIMKSGGTEEEASRATKEFMENICMKAVNQSVGRAIRHANDYANIYLLDVR 818

  Fly   820 FADPKIRGKLPKWISRHIVEANAANGGFGAVQGRTARFFKGR 861
            :..|..|.||.:|:...|...:..:    .|...|.:||..|
Yeast   819 YNRPNFRKKLSRWVQDSINSEHTTH----QVISSTRKFFSMR 856

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG11403	NP_569898.1	DinG	15..841	CDD:224120	292/930 (31%)
		DEXDc2	16..394	CDD:214693	145/454 (32%)
		Helicase_C_2	659..836	CDD:290046	78/187 (42%)
CHL1	NP_015317.1	PRK08074	<13..>50	CDD:236148	21/36 (58%)
		DEAD-like_helicase_N	36..>60	CDD:421690	13/23 (57%)
		rad3	136..849	CDD:273169	248/811 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157345769
Domainoid	1	1.000	144	1.000	Domainoid score	I993
eggNOG	1	0.900	-	-		E1_COG1199
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H68973
Inparanoid	1	1.050	346	1.000	Inparanoid score	I400
Isobase	1	0.950	-	0	Normalized mean entropy	S1862
OMA	1	1.010	-	-		QHG57144
OrthoFinder	1	1.000	-	-		FOG0003100
OrthoInspector	1	1.000	-	-		oto98943
orthoMCL	1	0.900	-	-		OOG6_102316
Panther	1	1.100	-	-	LDO	PTHR11472
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R199
SonicParanoid	1	1.000	-	-		X2476
TreeFam	1	0.960	-	-
	16	15.740