DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11403 and Ddx11

DIOPT Version :9

Sequence 1:	NP_569898.1	Gene:	CG11403 / 31072	FlyBaseID:	FBgn0026876	Length:	861	Species:	Drosophila melanogaster
Sequence 2:	XP_038940692.1	Gene:	Ddx11 / 316767	RGDID:	1306675	Length:	906	Species:	Rattus norvegicus

Alignment Length:	915	Identity:	342/915 - (37%)
Similarity:	502/915 - (54%)	Gaps:	106/915 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 GAQEFGFPYSPYEIQEQLMQELFQVLERGQVGIFESPTGTGKSLTLTCGALTWLARHEE---LVR 75
            |...|.||:.||.||:..|.||::|||.|::|||||||||||||:|.||||:||...|:   ...
  Rat     9 GGIHFPFPFPPYPIQKDFMAELYKVLEAGKIGIFESPTGTGKSLSLICGALSWLRDFEQKKLQAE 73

  Fly    76 TEMLARIRGVEQ-------ELAKLKEESEQ-----SSNWLESQGKSRAQRAELLRLQHLQALLDK 128
            ..:||...|...       ..:..:|.|:.     ..:|:....:.:.:|..:.||:..|....|
  Rat    74 AGLLAPASGPTSSGRNSVLSSSSCQEPSDTLRPAGDPDWVTEFVQKKEERDLVERLREEQLRRRK 138

  Fly   129 QEQQLDQI-----RKGAKKHKRQGRVHPGKLEELEKDL-----------------------DPES 165
            :|::|.::     |:.|.|..||.......|..|.:::                       :.||
  Rat   139 REERLQEVCQDGRRRFAAKRSRQEEEETETLLRLSREMLAADTAPEQLGQLECGEEHLVLAEYES 203

  Fly   166 DSDSEHETADGPQEAAEDRYRPVQIFFCSRTHSQLAQIVAELRKTPHGQSVRSISLGSRQQLCGN 230
            |.:.....||..::..|:.: ..:|::||||||||||.|.|::|:|.|:..|.:||||||.||.|
  Rat   204 DEERRGSRADEGEDDLEEEH-ITKIYYCSRTHSQLAQFVREVQKSPFGKETRLVSLGSRQSLCVN 267

  Fly   231 PAVRKLKHVGLMNERCLDMAT---KKARPNPSKKSRLTAEANSRCPFKAASLVESLRDLALTEPL 292
            ..|:.|..|.|||:||:||..   ||.|....|..|...:..:.|||.....:|.|||..|.|..
  Rat   268 EDVKSLGSVHLMNDRCVDMQRRKHKKMRIGEDKPKRRRQKMQASCPFYNHEQMELLRDEILLEVK 332

  Fly   293 DIEELANEGTACGGCSYYASRSAVEHAQLILLPYQLLLQKSARNQLGISLKGSIVIVDEAHNLLD 357
            |:|:|...|.....|.||.||.|:..|||::|||.:||..:.|...||.|:|.:||:||||||:|
  Rat   333 DMEQLVALGKEAQACPYYGSRFAIPAAQLVVLPYPMLLHAATRQAAGIRLQGQVVIIDEAHNLID 397

  Fly   358 SVAQLHGSEISRQQLERAKVQISGYKDHFQKRFTTKNLLKINQIIFIIRRLLKILDQRKELQSNG 422
            ::..:|.:|::..||.:|..|:..|.:.::||...|||:.|.||::::.:.:.:|....:...:.
  Rat   398 TITNIHSTEVNGSQLCQAHSQLLQYMERYRKRLKAKNLMYIKQILYLLDKFVAVLGGNVKQNPST 462

  Fly   423 CSMMRT-YELTAEGDFF------NIDLCELLDFCARTRFARKVQGRADRMEREPRPSENQAPVST 480
            .|:.:| .||.:..||.      ||:|.::..:..::..:||:.|                 .:.
  Rat   463 QSLPQTGSELQSINDFLFQSQVDNINLFKVQRYLEKSMLSRKLFG-----------------FTE 510

  Fly   481 ARSLILQRLASEQKLKEKTKSVKRRVEDINKEDKAEELQEQQKPTKKPVEEVAPSPIRPLLAFLE 545
            ...::|..| |:.:........::.::.:......:.|:|.|....:|.     ||:..:.||||
  Rat   511 CFGVVLPSL-SDSEENRGLGGFQQFLKSLQSGPPEDSLEEGQAVALRPA-----SPLMHIEAFLE 569

  Fly   546 TLTSNAEDGRILVDPVG----GTLKYILLDPAEQFADIVAEARAIVIAGGTMQPTKELKEQLFTG 606
            .||:..:|||::|:..|    .:||::||:||..||.:|.|.||:|||||||||..:.:|||. .
  Rat   570 ALTTANQDGRVIVNRQGSVGQSSLKFLLLNPAVHFAQVVKECRALVIAGGTMQPVSDFREQLL-A 633

  Fly   607 CH----DRLVERFYNHVVANDAILPFVISNGPSGAPLSFKFAHRGSAEMLRELSMILRNLCQVVP 667
            |.    .|:||....||:..|.|||.:|.:|||...|.|.:..|...:|:.|...||.|||.|||
  Rat   634 CSGVEASRVVEFSCGHVIPPDNILPLIICSGPSNQQLEFTYQRRELPQMMEETGRILCNLCNVVP 698

  Fly   668 GGVVCFLPSYEYLDKVYKYLEQSGTLETISGRKSVFREV--SGSAEQLLDNYALAIKRPAS---- 726
            ||:||||||||||.:|:.:.:::|.|..:|.||.:|:|.  :...||:|..|:..|   ||
  Rat   699 GGMVCFLPSYEYLRQVHAHWDKTGLLARLSVRKKIFQEPKRASQVEQVLTAYSTCI---ASCSHS 760

  Fly   727 ----YGALLLSVVGGKLSEGLNFADDLGRAVLVVGLPYSNSLSPELRQRMQHLDEKL-----GPG 782
                .|||||||||||:|||:||:|||||.|::||:||.|..||||:::|.:||:.:     .|.
  Rat   761 EGHLTGALLLSVVGGKMSEGINFSDDLGRCVVMVGMPYPNIKSPELQEKMAYLDQTIPRTHGQPP 825

  Fly   783 AGNEYYENLCVKAVNQCIGRAVRHIKDYACVYLLDKRFADPKIRGKLPKWISRHIVEANAANG-G 846
            .|....||||:||:||.||||:||.||:|.:.|||.|:|.|.|..|||.|| |..||..|..| .
  Rat   826 PGTVLIENLCMKAINQSIGRAIRHQKDFASIVLLDHRYARPSILAKLPAWI-RDRVEVKATFGPA 889

  Fly   847 FGAVQ 851
            |.|::
  Rat   890 FAAMR 894

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11403	NP_569898.1	DinG	15..841	CDD:224120	337/901 (37%)
		DEXDc2	16..394	CDD:214693	152/423 (36%)
		Helicase_C_2	659..836	CDD:290046	99/191 (52%)
Ddx11	XP_038940692.1	Csf4_U	23..>113	CDD:357161	34/89 (38%)
Ddx11	XP_038940692.1	rad3	225..889	CDD:273169	278/691 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351721
Domainoid	1	1.000	185	1.000	Domainoid score	I3315
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H68973
Inparanoid	1	1.050	462	1.000	Inparanoid score	I1493
OMA	1	1.010	-	-		QHG57144
OrthoDB	1	1.010	-	-		D141017at33208
OrthoFinder	1	1.000	-	-		FOG0003100
OrthoInspector	1	1.000	-	-		oto95485
orthoMCL	1	0.900	-	-		OOG6_102316
Panther	1	1.100	-	-	LDO	PTHR11472
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2476
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.910