DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11403 and brip1

DIOPT Version :9

Sequence 1:	NP_569898.1	Gene:	CG11403 / 31072	FlyBaseID:	FBgn0026876	Length:	861	Species:	Drosophila melanogaster
Sequence 2:	XP_002933884.1	Gene:	brip1 / 100489959	XenbaseID:	XB-GENE-492370	Length:	1229	Species:	Xenopus tropicalis

Alignment Length:	981	Identity:	248/981 - (25%)
Similarity:	393/981 - (40%)	Gaps:	241/981 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSQYTPNQRLDTPGAQEFGFPYSPYEIQEQLMQELFQVLERGQVGIFESPTGTGKSLTLTCGALT 65
            :|:|       |.|..:..||...|..|..:|..:.:.|...|..:.|||||:||||.|.|.||.
Frog     5 LSEY-------TIGGVKILFPCRAYPSQLAMMNSIMRGLNCKQHCLLESPTGSGKSLALLCSALA 62

  Fly    66 WLARHEELVRTEMLARIRGVEQELAK------------LKEESEQS---------------SNWL 103
            |    ::.:..:.....:..|:|..|            |:...|.|               ||:.
Frog    63 W----QQSLYGKQAVDEKSNEKECTKMERVTPCCCSCHLRNSDELSFNSSNRQMNSTDSTPSNFQ 123

  Fly   104 ESQGKSRAQRAELLRLQHLQALLDKQEQQLDQIRKGAKKHKRQGRVHPGKLEEL----------- 157
            .:........|:|...:....:.|:.:......::..:.|..|.:....:..|.
Frog   124 GASSNKTTLAAKLCAKKQASFIADQDDDFQTDRKRIRQSHDEQQQAKKRRCYEKGVQFIDDDFNR 188

  Fly   158 -EKDLDPESD-------------SDSEHETADGP--------QEAAEDRY------------RPV 188
             ..|||..:.             |.|.|..  ||        |...||:.            :..
Frog   189 NHTDLDSHNQKKASMDSCPEVIASSSNHSV--GPCSLCLCDGQTKEEDKAIEKGKKENGEKPKVP 251

  Fly   189 QIFFCSRTHSQLAQIVAELRKTPHGQSVRSISLGSRQQLCGNPAVRKLKHVGLMNERCLDMATKK 253
            :|||.:|||.|:|||..|||:|.: .|||...|.||:..|.:|.:...:     ||:|
Frog   252 KIFFGTRTHKQIAQITRELRRTAY-SSVRMTILSSREHTCVHPDIHSNR-----NEKC------- 303

  Fly   254 ARPNPSKKSRLTAEANSRCPFKAASLVESLRDLAL-------TEPLDIEELANEGTACGGCSYYA 311
                   |..|.|:....|.|...  |:.:.:..|       .:..|||||...|.....|.|:|
Frog   304 -------KELLEAKDGHSCRFYHG--VQKMNEQNLLKYRHGVDKAWDIEELVGLGKRLRACPYFA 359

  Fly   312 SRSAVEHAQLILLPYQLLLQKSARNQLGISLKGSIVIVDEAHNLLDSVAQLHGSEISRQQLERAK 376
            :|..::.|.::..||..||....|..:.|.|:|.:||:|||||:.|...:......|.:||..|:
Frog   360 ARELMQEADIVFCPYNYLLDSQIRESMDIFLEGQVVILDEAHNIEDCARESASFSCSDEQLMYAR 424

  Fly   377 VQISGYKDHFQKRFTTKNLLKINQIIFIIRRLLKILDQRKELQSNGCSMMRTYELTAEGDFFNID 441
            .:|....:|.                      :::.|..              .|.|
Frog   425 DEIDSMVNHG----------------------IRVSDHE--------------PLRA-------- 445

  Fly   442 LCELLDFCARTRFARKVQGRADRMEREPRPSENQAPVSTARSL--ILQRL----ASEQKLKEKTK 500
            :|..|     |.:.|:...:.  :|||   .|....|...:.:  |...:    |:...||....
Frog   446 VCYSL-----TNWIRECSDQL--VERE---YEASCKVWNGKEILAIFHDMGITNATFPLLKANLA 500

  Fly   501 SVKRRVEDINKEDKAEELQEQQK----PTKKPVEEVAPSPIRPLLAFLETLTSN----AEDGRI- 556
            :|      :.||:|...|..|:.    ||..|..::.   ::.|...|:.|...    |||.||
Frog   501 AV------VEKEEKITMLHGQENVIKIPTLSPQTQMV---LKGLFLVLDYLFRQNNRFAEDYRIA 556

  Fly   557 ------------LVDPVG-----------------GTLKYILLDPAEQFADIVAEARAIVIAGGT 592
                        :.|..|                 .||.:..|:||..|:|:.:.||.||:..||
Frog   557 LQQSYTWANRQDIPDENGFFARPRNRRAVRQKIMVYTLNFWCLNPAVAFSDLSSNARTIVLTSGT 621

  Fly   593 MQPTKELKEQL---FTGCHDRLVERFYNHVVANDAILPFVISNGPSGAPLSFKFAHRGSAEMLRE 654
            :.|......:|   |:      ::...|||:....:....:..||.|..|...|.|..:.:...|
Frog   622 LSPMGSFSSELGVKFS------IQLEANHVIHKSQVWVGTVGAGPKGRKLCATFQHTETFDFQDE 680

  Fly   655 LSMILRNLCQVVPGGVVCFLPSYEYLDKVYKYLEQSGTLETISGRKSVFREVSG----SAEQLLD 715
            :..:|.::||.|..||:||||||:.|:|:......:|..|.:...|:|.:|..|    ..:::|.
Frog   681 IGALLLSVCQTVSHGVLCFLPSYKMLEKLKDRWMHTGLWENLERIKTVIKEPQGGDKTDFDKMLQ 745

  Fly   716 NYALAIK-RPASYGALLLSVVGGKLSEGLNFADDLGRAVLVVGLPYSN--SLSPELRQRM--QHL 775
            .|..||: :....||||::|..||:||||:|:|:..|||:.||:|:.|  .|..||:::.  ||.
Frog   746 MYYDAIRYKGEKDGALLIAVCRGKVSEGLDFSDNNARAVVTVGIPFPNIKDLQVELKRKYNDQHA 810

  Fly   776 DEKLGPGAGNEYYENLCVKAVNQCIGRAVRHIKDYACVYLLDKRF-ADPKIRGKLPKWISRHIVE 839
            ..: |...|:::||....:|:||.:||.:||..|:..:.|:|.|| ::||....|.||:.:.:..
Frog   811 KSR-GLLPGSQWYEIQAYRALNQALGRCIRHKNDWGALILVDDRFRSNPKYITGLSKWVRQLVQH 874

  Fly   840 ANAANG 845
            .:..||
Frog   875 HSTFNG 880

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11403	NP_569898.1	DinG	15..841	CDD:224120	242/961 (25%)
		DEXDc2	16..394	CDD:214693	111/456 (24%)
		Helicase_C_2	659..836	CDD:290046	70/186 (38%)
brip1	XP_002933884.1	DEAD-like_helicase_N	43..>68	CDD:391939	14/28 (50%)
brip1	XP_002933884.1	rad3	246..885	CDD:273169	198/727 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D141017at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920