DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eIF4E7 and ife-1

DIOPT Version :9

Sequence 1:	NP_726718.1	Gene:	eIF4E7 / 31059	FlyBaseID:	FBgn0040368	Length:	429	Species:	Drosophila melanogaster
Sequence 2:	NP_001255196.1	Gene:	ife-1 / 176755	WormBaseID:	WBGene00002059	Length:	231	Species:	Caenorhabditis elegans

Alignment Length:	226	Identity:	84/226 - (37%)
Similarity:	128/226 - (56%)	Gaps:	28/226 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   212 DAVVAFDNSLEFLSLNNKCDDDLTIAAENAELLEVED---PQHPLNNCWTLWYLENDRNKSWEEM 273
            |:.:||:.              |.|:.|...:.|.|.   |.:||...||.|||.::||||||:.
Worm     3 DSEIAFEK--------------LKISGEKEGMTETEQTTAPIYPLKRNWTWWYLNDERNKSWEDR 53

  Fly   274 LHKVTSFDTVEKFWSLITHIKPPSELMLGSDYSLFKKGIRPMWEDEANVNGGRW--VINLTKSAK 336
            |.||.:|:||.:||:|...|:|||.|....||::|:..|:||||...|.|||||  ||:..|:.:
Worm    54 LKKVYTFNTVSEFWALYDAIRPPSGLNALCDYNVFRDDIQPMWEVPENSNGGRWLIVIDKGKTPE 118

  Fly   337 MALDSFWMDAMLCLIGEAC-KHSDDLCGVVVNIRGKSNKISIWNADGGNQTTVLEIGRILRKVLR 400
            | :|:.|::.::.|:||.. |..:.:||:|.|:|||.:|||:|..|..:..|.:.||.:|::.|.
Worm   119 M-VDAIWLEILMALVGEQFGKDMESICGLVCNVRGKGSKISVWTKDCNDDETNMRIGVVLKEKLM 182

  Fly   401 MDN-------IYVLEYQLHKDSKDKLGSTVK 424
            ..:       ..|:.|:.|:..:.|..|.||
Worm   183 AASKDHSKPLFDVIRYEDHESCQKKTSSVVK 213

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF4E7	NP_726718.1	IF4E	255..409	CDD:279921	67/163 (41%)
ife-1	NP_001255196.1	IF4E	37..181	CDD:279921	65/144 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160156160
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1394271at2759
OrthoFinder	1	1.000	-	-		FOG0000666
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11960
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X406
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.950