Protein Alignment Lztr1 and Lztr1

DIOPT Version :10

• Sequence 1: NP_001259114.1
• Gene: Lztr1 / 31037
• FlyBaseID: FBgn0040344
• Length: 998
• Species: Drosophila melanogaster
• Sequence 2: NP_080084.2
• Gene: Lztr1 / 66863
• MGIID: 1914113
• Length: 837
• Species: Mus musculus
• Alignment Length: 833
• Identity: 423/833 - (50%)
• Similarity: 552/833 - (66%)
• Gaps: 83/833 - (9%)

  Fly   203 ASSGSGSGSGKAT-------SPG---SYSCN----ALNVDFTSYTATHQWTRMLECAEFVGAKRS 253
            |.||...|||..|       :|.   .:||:    .|.::|..:...|:|.|:..|.|||||:||
Mouse     2 AGSGGPIGSGALTGGVRSKVAPSVDFDHSCSDSVEYLTLNFGPFETVHRWRRLPPCDEFVGARRS 66

  Fly   254 KHTVVAYKDAMFVFGGDNGKNMLNDLIRFGVKDKSWGRACATGTPPAPRYHHSAVVAGSSMFIFG 318
            ||||||||||::||||||||.|||||:||.|||.||.||..|||||||||||||||.|||||:||
Mouse    67 KHTVVAYKDAIYVFGGDNGKTMLNDLLRFDVKDCSWCRAFTTGTPPAPRYHHSAVVYGSSMFVFG 131

  Fly   319 GYTGDIHSNSNLTNKNDLFEYKFQSAMWVEWKFSGRQPVPRSAHGAAVYDNKMWIYAGYDGNARL 383
            ||||||:|||||.||||||||||.:..|.|||..||.||.||||||.||.:|:||:|||||||||
Mouse   132 GYTGDIYSNSNLKNKNDLFEYKFATGQWTEWKIEGRLPVARSAHGATVYSDKLWIFAGYDGNARL 196

  Fly   384 NDMWTLNLTGENQ--WEEVDQLGDRPPTCCNFPVAVARDAMYVFSGQSGLQITNSLFEFHFKTRT 446
            |||||:.|.....  ||||.|.|:.||:||||||||.||.|:|||||||.:|||:||:|.||.:|
Mouse   197 NDMWTIGLQDRELTCWEEVAQSGEIPPSCCNFPVAVCRDKMFVFSGQSGAKITNNLFQFEFKDKT 261

  Fly   447 WRRISNEPVLRGATSAPPSRRYGHTMVHHDRFLYVFGGSADSTLPNDLHCYDLDSQVWSVIQPEQ 511
            |.||..|.:||| :..||.||||||||..||.||||||:||:||||:|||||:|.|.|.|:||..
Mouse   262 WTRIPTEHLLRG-SPPPPQRRYGHTMVAFDRHLYVFGGAADNTLPNELHCYDVDFQTWEVVQPSS 325

  Fly   512 NSDV----------------------------------------------------PSGRVFHAS 524
            :|:|                                                    ||||:|||:
Mouse   326 DSEVGGAEMPERASSSEDASTLTSEERSSFKKSRDVFGLDFGTTSAKQPVHLASELPSGRLFHAA 390

  Fly   525 AVICDAMYIFGGTVDNSVRRGDTYRFQFSSYPKCTLRDDFGKFFQDKQFCDIQFIVGAEEIRILA 589
            |||.||||||||||||::|.|:.||||||.||||||.:|:|:.::.:||||::|::|.:|..:..
Mouse   391 AVISDAMYIFGGTVDNNIRSGEMYRFQFSCYPKCTLHEDYGRLWEGRQFCDVEFVLGEKEECVQG 455

  Fly   590 HIAFVAARSKYLRNKILAAREARQQQMEKVYGVGQVDALALNAGAGGDRGPMLEVRLANASPEAF 654
            |:|.|.|||::||.||:.|:|...|::|:...:...:  |.....|..|.|:|.|.:..|....|
Mouse   456 HVAIVTARSRWLRRKIVQAQEWLAQKLEEDGALAPKE--APGPAVGRARPPLLRVAIREAEARPF 518

  Fly   655 EIILNYIYTDRIDLKDTYSKNIIILITDIYQLAGLFTMPRLAHGCIQYLDYKINKLNVLEALYNA 719
            |:::.::|||:|..........::||.|:|:||..|.:.||...|.||::..::..|||....:|
Mouse   519 EVLMQFLYTDKIKYPRKGHVEDVLLIMDVYKLALSFQLCRLEQLCRQYIEASVDLQNVLVVCESA 583

  Fly   720 DKSNIKIIKDHCMQFIIKEENFTDVVMSSEFSDLDKPLLVEIIRKRLY-----PSKLVIDTSYEG 779
            .:..:..:|:||:.||:||.:|..|:|..||..|..||:|||:|::..     ||...:|
Mouse   584 ARLQLGQLKEHCLNFIVKESHFNQVIMMKEFERLSSPLIVEIVRRKQQPPPRTPSDQPVD----- 643

  Fly   780 NIGTTLEIDLCAFLESTGKDFCDISLVLEDHVIPAHKSVLSSRCTYFQGMFRSFMPPDNTVNIQI 844
             |||:|..|:.|:||..|.:||||:|:|:....||||::|::|.:||:.|||||||.|..|||.|
Mouse   644 -IGTSLIQDMKAYLEGAGSEFCDITLLLDGQPRPAHKAILAARSSYFEAMFRSFMPEDGQVNISI 707

  Fly   845 GEISPSLEAFHSLLRYIYYGETKMPPQDALYLFQAPCFYGLANNRLHAFCKYSLEHNITFENVLQ 909
            ||:.||.:||.|:||||||||..|||:|:||||.||.:||..||||.|:||.:||.|:|.:||||
Mouse   708 GEMVPSRQAFESMLRYIYYGEVNMPPEDSLYLFAAPYYYGFYNNRLQAYCKQNLEMNVTVQNVLQ 772

  Fly   910 TLEASDITKIYDIKEYALKLIVKDFAKVARLPKIAGLSRELLLEIIRAVADSH 962
            .|||:|.|:..|:|.:.|.:||..|.||::||.:..||::|||:||.::| ||
Mouse   773 ILEAADKTQALDMKRHCLHIIVHQFTKVSKLPTLRLLSQQLLLDIIDSLA-SH 824

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lztr1	NP_001259114.1	NanM	252..551	CDD:442289	216/352 (61%)
		KELCH repeat	252..298	CDD:276965	36/45 (80%)
		KELCH repeat	302..355	CDD:276965	41/52 (79%)
		KELCH repeat	359..407	CDD:276965	32/49 (65%)
		KELCH repeat	410..455	CDD:276965	31/44 (70%)
		KELCH repeat	467..509	CDD:276965	30/41 (73%)
		BTB1_POZ_LZTR1	551..704	CDD:349617	57/152 (38%)
		BACK1_LZTR1	708..766	CDD:350580	23/57 (40%)
		BTB2_POZ_LZTR1	781..906	CDD:349618	73/124 (59%)
		BACK2_LZTR1	902..962	CDD:350581	28/59 (47%)
Lztr1	NP_080084.2	NanM	51..417	CDD:442289	248/419 (59%)
		KELCH repeat	65..111	CDD:276965	37/45 (82%)
		Kelch 1. /evidence=ECO:0000255	76..125		40/48 (83%)
		KELCH repeat	115..169	CDD:276965	39/53 (74%)
		Kelch 2. /evidence=ECO:0000255	127..182		39/54 (72%)
		Kelch 3. /evidence=ECO:0000255	184..235		33/52 (63%)
		Kelch 4. /evidence=ECO:0000255	236..282		28/45 (62%)
		KELCH repeat	281..323	CDD:276965	28/93 (30%)
		Kelch 5. /evidence=ECO:0000255	292..338		32/97 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	324..352		21/27 (78%)
		Kelch 6. /evidence=ECO:0000255	396..447		16/50 (32%)
		BTB1_POZ_LZTR1	417..568	CDD:349617	48/155 (31%)
		BACK1_LZTR1	572..630	CDD:350580	25/57 (44%)
		BTB2_POZ_LZTR1	644..769	CDD:349618	67/118 (57%)
		BACK2_LZTR1	765..825	CDD:350581