DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lztr1 and KLHDC4

DIOPT Version :10

Sequence 1:NP_001259114.1 Gene:Lztr1 / 31037 FlyBaseID:FBgn0040344 Length:998 Species:Drosophila melanogaster
Sequence 2:NP_060036.2 Gene:KLHDC4 / 54758 HGNCID:25272 Length:520 Species:Homo sapiens


Alignment Length:408 Identity:94/408 - (23%)
Similarity:143/408 - (35%) Gaps:115/408 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   179 PPGSSCSSG----PGGSGCSMAYDAASNASSGSGSGSGKATSPGSYSCNALNVDFTSYTATHQWT 239
            ||...|:..    |.|.|....:             .|:..||...........:..:.||..|.
Human   115 PPPRRCAHQAVVVPQGGGQLWVF-------------GGEFASPNGEQFYHYKDLWVLHLATKTWE 166

  Fly   240 RMLECAEFVGAKRSKHTVVAYKDAMFVFGG--DNGKNML--NDLIRFGVKDKSWGRACATGTPPA 300
            ::.......|  ||.|.:||:|..:.:|||  ::.::.:  ||:..|.:...:|.:...:||.|.
Human   167 QVKSTGGPSG--RSGHRMVAWKRQLILFGGFHESTRDYIYYNDVYAFNLDTFTWSKLSPSGTGPT 229

  Fly   301 PRYH-HSAVVAGSSMFIFGGYT----------GDIHSNSNLTNKNDLFEYKFQSAMWVEWKFSGR 354
            ||.. ..:|.....:.::|||:          |..||:..|....|..|.|:   :|.....||.
Human   230 PRSGCQMSVTPQGGIVVYGGYSKQRVKKDVDKGTRHSDMFLLKPEDGREDKW---VWTRMNPSGV 291

  Fly   355 QPVPRSAHGAAVYDNKMWIYAG----------YDGNARLNDMWTLNLTGENQWEEVDQL------ 403
            :|.|||....|:..|...::.|          ..|.. .||::..:.| .|:|.| .||      
Human   292 KPTPRSGFSVAMAPNHQTLFFGGVCDEEEEESLSGEF-FNDLYFYDAT-RNRWFE-GQLKGPKSE 353

  Fly   404 -------------GDRPPTC----CNFPV-----AVARDAMYV----------FSGQSGLQITNS 436
                         |...|.|    ...||     .||.|...|          .:||...:..:|
Human   354 KKKRRRGRKEEPEGGSRPACGGAGTQGPVQLVKEVVAEDGTVVTIKQVLTAPGSAGQPRSEDEDS 418

  Fly   437 LFEFHFKTRTWRRISNEPVLRGATSAPPSRRYGHTMVHHDRFLYVFGGSADS-----TLPNDLHC 496
            |.|                 .|:.:..|..|....:......|||:||..::     || :||||
Human   419 LEE-----------------AGSPAPGPCPRSNAMLAVKHGVLYVYGGMFEAGDRQVTL-SDLHC 465

  Fly   497 YDLD-SQVWSVI---QPE 510
            .||. .:.|..:   .||
Human   466 LDLHRMEAWKALVEMDPE 483

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Lztr1NP_001259114.1 NanM 252..551 CDD:442289 81/331 (24%)
KELCH repeat 252..298 CDD:276965 14/49 (29%)
KELCH repeat 302..355 CDD:276965 15/63 (24%)
KELCH repeat 359..407 CDD:276965 15/76 (20%)
KELCH repeat 410..455 CDD:276965 12/63 (19%)
KELCH repeat 467..509 CDD:276965 15/50 (30%)
BTB1_POZ_LZTR1 551..704 CDD:349617
BACK1_LZTR1 708..766 CDD:350580
BTB2_POZ_LZTR1 781..906 CDD:349618
BACK2_LZTR1 902..962 CDD:350581
KLHDC4NP_060036.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..33
NanM 59..342 CDD:442289 57/246 (23%)
KELCH repeat 64..115 CDD:276965 94/408 (23%)
Kelch 1 77..129 3/13 (23%)
KELCH repeat 119..174 CDD:276965 10/67 (15%)
Kelch 2 133..187 12/68 (18%)
KELCH repeat 177..226 CDD:276965 13/48 (27%)
Kelch 3 188..241 13/52 (25%)
KELCH repeat 231..293 CDD:276965 15/64 (23%)
Kelch 4 243..289 11/48 (23%)
Kelch 5 308..361 10/55 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 346..379 5/32 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 402..431 7/45 (16%)
KELCH repeat 432..480 CDD:276965 15/48 (31%)
Kelch 6 443..494 16/42 (38%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 481..520 2/3 (67%)
Blue background indicates that the domain is not in the aligned region.

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