Protein Alignment Lztr1 and Klhdc4

DIOPT Version :10

• Sequence 1: NP_001259114.1
• Gene: Lztr1 / 31037
• FlyBaseID: FBgn0040344
• Length: 998
• Species: Drosophila melanogaster
• Sequence 2: NP_663580.2
• Gene: Klhdc4 / 234825
• MGIID: 2384569
• Length: 584
• Species: Mus musculus
• Alignment Length: 283
• Identity: 65/283 - (22%)
• Similarity: 118/283 - (41%)
• Gaps: 46/283 - (16%)

  Fly   261 KDAMFVFGGD--NGKN--MLNDLIRFGVKDKSWGRACATGTPPAPRYHHSAVV---AGSSMFIFG 318
            ||.:.:|||:  ||:.  |.|:|..:.::..:|.:....|.||. |..|.|||   .|..:::||
Mouse    75 KDELILFGGEYFNGQKTFMYNELYIYSIRKDTWTKVDIPGPPPR-RCAHQAVVVPQGGGQLWVFG 138

  Fly   319 GYTGDIHSNSNLTNKNDLFEYKFQSAMWVEWKFSGRQPVPRSAHGAAVYDNKMWIYAGYDGNAR- 382
            |.... .......:..||:.....:..|.:.:.:| .|..||.|....:..::.::.|:..:||
Mouse   139 GEFAS-PDGEQFYHYKDLWVLHLATKTWEQIRSTG-GPSGRSGHRMVAWKRQLILFGGFHESARD 201

  Fly   383 ---LNDMWTLNLTGENQWEEVDQLGDRPPTCCNFPVAVA-RDAMYVFSGQSGLQITNSLFE---- 439
               .:|::|.:| ...||.::...|..|.......:||. :.::.::.|.|..::...:.:
Mouse   202 YIYYSDVYTFSL-DTFQWSKLSPSGPGPTPRSGCLMAVTPQGSIAIYGGYSKQRVKKDVDKGTQH 265

  Fly   440 ---FHFKTR-------TWRRISNEPVLRGATSAPPSRRYGHTM-VHHDRFLYVFGG--------S 485
               |..|..       .|.||:       .:...|:.|.|.:: |..:..:.||||        |
Mouse   266 SDMFLLKPAEGGEGKWAWTRIN-------PSGVKPTARSGFSVAVAPNHQILVFGGVCDEEEEES 323

  Fly   486 ADSTLPNDLHCYDLDSQVWSVIQ 508
            .:.:..:||:.||.....|...|
Mouse   324 LEGSFFSDLYIYDSAKSRWFAAQ 346

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lztr1	NP_001259114.1	NanM	252..551	CDD:442289	65/283 (23%)
		KELCH repeat	252..298	CDD:276965	12/40 (30%)
		KELCH repeat	302..355	CDD:276965	13/55 (24%)
		KELCH repeat	359..407	CDD:276965	12/51 (24%)
		KELCH repeat	410..455	CDD:276965	9/59 (15%)
		KELCH repeat	467..509	CDD:276965	14/51 (27%)
		BTB1_POZ_LZTR1	551..704	CDD:349617
		BACK1_LZTR1	708..766	CDD:350580
		BTB2_POZ_LZTR1	781..906	CDD:349618
		BACK2_LZTR1	902..962	CDD:350581
Klhdc4	NP_663580.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..33
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	50..69
		NanM	59..345	CDD:442289	64/280 (23%)
		KELCH repeat	64..115	CDD:276965	11/39 (28%)
		Kelch 1	77..129		17/52 (33%)
		KELCH repeat	119..174	CDD:276965	13/56 (23%)
		Kelch 2	133..187		11/55 (20%)
		KELCH repeat	177..223	CDD:276965	11/46 (24%)
		Kelch 3	188..238		10/50 (20%)
		KELCH repeat	231..293	CDD:276965	9/68 (13%)
		Kelch 4	243..289		7/52 (13%)
		Kelch 5	308..361		11/39 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	348..381
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	405..433
		Kelch_1	431..480	CDD:396078
		KELCH repeat	432..480	CDD:276965
		Kelch 6	443..494
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	482..533