DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lztr1 and F53E4.1

DIOPT Version :9

Sequence 1:	NP_001259114.1	Gene:	Lztr1 / 31037	FlyBaseID:	FBgn0040344	Length:	998	Species:	Drosophila melanogaster
Sequence 2:	NP_001368706.1	Gene:	F53E4.1 / 180050	WormBaseID:	WBGene00009978	Length:	432	Species:	Caenorhabditis elegans

Alignment Length:	360	Identity:	91/360 - (25%)
Similarity:	139/360 - (38%)	Gaps:	88/360 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   238 WTRMLECAEFVGAKRSKHTVVAYKDAMFVFGG------DNGKNML-------------------- 276
            ||..||    .|.:|..|..:|....::.|||      .:.|:.|
Worm    10 WTVHLE----GGPRRVNHASIAVGSRIYSFGGYCSGEVTDAKDPLDVHVLNTENYRWIKMNPGYV 70

  Fly   277 --NDLIR-------FGVKDKSWGRACATGTPPAPRYHHSAVVAGSSMFIFGGYTGDIHSNSNLTN 332
              |.:|.       :...||.:|..      |..||.|:.|......:::||...| :...||
Worm    71 YNNRIITKATIESPYSDSDKMFGAV------PYQRYGHTVVEYQGKAYVWGGRNDD-YGACNL-- 126

  Fly   333 KNDLFEYKFQSAMWVEWKFSGRQPVPRSAHGAAVYDNKMWIYAGYDGNARLNDMWTLNLT-GENQ 396
               |.||..:..:|.:.:..|..|..|..|.|.|::|:|:::.||:.:|:.....|.... ..:.
Worm   127 ---LHEYDPEYNVWKKVEIEGFVPPSRDGHTAVVWNNQMFVFGGYEEDAQRFSQETYVFDFATST 188

  Fly   397 WEEVDQLGDRPPTCCNFPVAVARDA-MYVFSGQSGL---------------QITNSLFEFHFKTR 445
            |.|:....| ||...:|..|...|. ||:|.|:|..               |..::|...:..|.
Worm   189 WREMHTKND-PPRWRDFHTASVIDGMMYIFGGRSDESGQVGDEHLFHTIHDQYDDTLMALNLATG 252

  Fly   446 TWRRISNEPVLRGATSAP-----PSRRYGHTMVHHDRFLYVFGG--SADSTLPNDLHCYDLDSQV 503
            .|.|          |..|     |..|..|:...:|..:|:|||  ...:...|:|:|:|..:.:
Worm   253 AWTR----------TKVPENTMKPGGRRSHSTWVYDGKMYMFGGYLGTINVHYNELYCFDPKTSM 307

  Fly   504 WSVIQPEQNSDVPSGRVFHASAVICDAMYIFGGTV 538
            ||||  ......||.|..|.|.|....:|:||||:
Worm   308 WSVI--SVRGTYPSARRRHCSVVSNGKVYLFGGTM 340

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lztr1	NP_001259114.1	PLN02153	237..554	CDD:177814	91/360 (25%)
		KELCH repeat	252..298	CDD:276965	13/80 (16%)
		Kelch_3	261..310	CDD:290151	15/83 (18%)
		Kelch_5	299..>329	CDD:290565	8/29 (28%)
		KELCH repeat	302..355	CDD:276965	14/52 (27%)
		Kelch_1	358..400	CDD:279660	11/42 (26%)
		KELCH repeat	359..407	CDD:276965	13/48 (27%)
		KELCH repeat	410..455	CDD:276965	13/60 (22%)
		Kelch_1	410..452	CDD:279660	13/57 (23%)
		Kelch_1	466..509	CDD:279660	15/44 (34%)
		KELCH repeat	467..509	CDD:276965	15/43 (35%)
		BTB	564..704	CDD:279045
		BTB	575..707	CDD:197585
		SPOP_C_like	707..766	CDD:269810
		BTB	798..898	CDD:279045
		BTB	802..902	CDD:197585
		SPOP_C_like	902..960	CDD:269810
F53E4.1	NP_001368706.1	KELCH repeat	99..148	CDD:276965	14/54 (26%)
		KELCH repeat	150..192	CDD:276965	11/41 (27%)
		KELCH repeat	202..266	CDD:276965	15/73 (21%)
		KELCH repeat	269..312	CDD:276965	15/44 (34%)
		Kelch_2	19..67	CDD:400133	8/47 (17%)
		KELCH repeat	20..91	CDD:276965	11/70 (16%)
		PLN02153	79..>338	CDD:177814	73/283 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1494
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940