DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG16989 and HEATR6

DIOPT Version :10

Sequence 1:NP_569860.3 Gene:CG16989 / 31026 FlyBaseID:FBgn0025621 Length:1045 Species:Drosophila melanogaster
Sequence 2:NP_071353.4 Gene:HEATR6 / 63897 HGNCID:24076 Length:1181 Species:Homo sapiens


Alignment Length:1106 Identity:307/1106 - (27%)
Similarity:484/1106 - (43%) Gaps:188/1106 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly    15 DQEEADRDSHLQLVREVDHNVGVPVGVA----------AYRL-----QQLIAGVRARGHHDLLRL 64
            |...|..:.||...:.:..|.....|||          |.||     ..|::.|....||.|.||
Human    44 DSSSARTEIHLLFDQLISENYSEGSGVAPEDVSALLVQACRLVPLNQNHLVSKVSQLIHHLLNRL 108

  Fly    65 WQLWLNE----LILAKKIILVR-----SHLLIEELLAGTELKPSVETVNLMLTVLKSTPKENLAG 120
             |:.::|    .:||..|..:.     :|..|.:.||........:....:..:|.:|      |
Human   109 -QVIVDEQHLDFLLAYTISAIHQCSSWTHREILQALAALVYCNGSKCQKYLPELLGNT------G 166

  Fly   121 FWPRLSALTHAKDMDVALLLLQCQDRVLAELEESPEVAEHNQGLVNSLINMHFEGRWLVAKEQLP 185
            ...:||.|..: |.:|....:.|...:...:...|.:.|..|       |:.|:....:.  |.|
Human   167 LLMKLSDLAQS-DPEVRRAAVHCMANLCLSVPGQPYLEEPYQ-------NVCFQAFLTIL--QSP 221

  Fly   186 -----------LLLAQSLQLIQKLVT--RQPDYAAQRVPELMGLVQCYLQYGAEGETHLKPRKLP 237
                       :||..:|:.||.|:.  |........:..|:.:::.::.:|..|.....|..|.
Human   222 KSSDMDDITFCMLLQNALKGIQSLLNGGRMKLTQTDELGALLAVLKKFMFHGLPGLNIEMPTVLY 286

  Fly   238 PAQQSAAYGQEKEEEDQLLAQMSRPCGRKNKVRKMRSLAKQRNQAVNEHHEPNPR-ERLVLMGNQ 301
            |.......|:...:..|..:..|||  ..||.:|.:...|:..|...|..|.:.. |...:.|..
Human   287 PTPLPQYDGRTPIKPQQSESSASRP--TLNKKKKSKVKPKKIQQGEEEEKESSGEIEAAPVTGTG 349

  Fly   302 DYGCLTGDS------GENGLPSD-----------------------------SDQQQTENKHHRH 331
            ......|::      |...||.|                             ||.:.......|.
Human   350 RVNLHEGNTWCPSSLGVQSLPLDGSGAAEKDGVSSSFSSSSWKRVSSSESDFSDAEGGMQSKMRS 414

  Fly   332 QEAKVRISALHLLSTLTNQLPRRSFYGYWHVLFPDGDAGGTPH---LLLLGLKDTNFRCRALALQ 393
            .:||||..||....:....:.::..||||....||....|:|.   |:.|.|||.:.:.||.|||
Human   415 YQAKVRQGALVCFLSTIKSIEKKVLYGYWSAFIPDTPELGSPQSVSLMTLTLKDPSPKTRACALQ 479

  Fly   394 VGAQLLYGSKAFLSQACSLGPSN--FTPFAVSLASSVLTAYRILIAILEREYTPPVLTQCLKCLA 456
            |.:.:|.|||.|||.|.......  ||||:|.:|.|:...:|.|:..|..|.:...:||.:||||
Human   480 VLSAILEGSKQFLSVAEDTSDHRRAFTPFSVMIACSIRELHRCLLLALVAESSSQTVTQIIKCLA 544

  Fly   457 VLVQATPFHQLEMGFVYEFVGHVKKLIKSSDPPVAVSALLVMEMLVGTSKLTPEI------ASSI 515
            .||...|:.:|::..:.:....:|..|:..|..|.||:|.::..:|.|....||:      ..|.
Human   545 NLVSNAPYDRLKLSLLTKVWNQIKPYIRHKDVNVRVSSLTLLGAIVSTHAPLPEVQLLLQQPCSS 609

  Fly   516 GLAPSQRNLQMEHASTAETYQELCDSDAEMELEEGDEQQQPSQNNVVNPVHTVSPTIPRNSWLLR 580
            ||..|  |....|.|..:.:::   :.|...|||         .:|.:|..:..|     .||:|
Human   610 GLGNS--NSATPHLSPPDWWKK---APAGPSLEE---------TSVSSPKGSSEP-----CWLIR 655

  Fly   581 QVLRCLEGMRI--------------------PSAVRLECFQVLQAMAT-HIGLLRGHQVRLSRVI 624
               .|:..:.:                    ||.:|||..|||..:|. :..:.:.:.:.|..||
Human   656 ---LCISIVVLPKEDSCSGSDAGSAAGSTYEPSPMRLEALQVLTLLARGYFSMTQAYLMELGEVI 717

  Fly   625 --SAGLTDPATDVKLYAARCLDSVGYQL-GRLLPE----PAERE---LQMSFWLTLL--PATYEA 677
              ..|..||:  ::|:.|:.|:.:|..| .:..|:    |.:|.   |.:.||..:|  |.....
Human   718 CKCMGEADPS--IQLHGAKLLEELGTGLIQQYKPDSTAAPDQRAPVFLVVMFWTMMLNGPLPRAL 780

  Fly   678 YDSAGFSLKCALCDALSNMGAISFERLPDGQRTALLAFLSGCASDDHEETLVRVAALRAMAVYVL 742
            .:|...:|:.:.|||||::...:|..||:.::...:..|.|.  :|.:..||:.|..||:.||||
Human   781 QNSEHPTLQASACDALSSILPEAFSNLPNDRQMLCITVLLGL--NDSKNRLVKAATSRALGVYVL 843

  Fly   743 HPSLRTDLGFVENAAELTLRILGDSQLLARIKAAWALGNISDALVAGI----PNQTERISAELLE 803
            .|.||.|:.||.:||...|..|.|..|..|.||||:|||::|.|:..:    |:..|..|..||.
Human   844 FPCLRQDVIFVADAANAILMSLEDKSLNVRAKAAWSLGNLTDTLIVNMETPDPSFQEEFSGLLLL 908

  Fly   804 RLIQAATKSCADNDKVRANAVRALGNLLQILQ---VQPLGNGELMQVAMSKLLDCVTLPGNAKVK 865
            :::::|.::..|.|||::||||||||||..||   ::.....|:::.::..|:..|......||:
Human   909 KMLRSAIEASKDKDKVKSNAVRALGNLLHFLQPSHIEKPTFAEIIEESIQALISTVLTEAAMKVR 973

  Fly   866 WNACYVIGNLVKHRAF---------FANNRLAGILFPTLCQLVVQHANFKVRTNAAGVLLQVKQR 921
            |||||.:||:.|:.|.         .|.|.|..::  |.|:      |||||..:|..|....:|
Human   974 WNACYAMGNVFKNPALPLGTAPWTSQAYNALTSVV--TSCK------NFKVRIRSAAALSVPGKR 1030

  Fly   922 EDFSA--HFPLLWRSLLDALVRSNVLESFEEYNHRDALQQQLCLAIAHLLLLARSSDLPMMRESL 984
            |.:.:  .:..:|.:|:.||.:|.....|.|:.:..:|:.|:|.|:.|||.||.:||||.|:|:|
Human  1031 EQYGSVDQYARIWNALVTALQKSEDTIDFLEFKYCVSLRTQICQALIHLLSLASASDLPCMKETL 1095

  Fly   985 E 985
            |
Human  1096 E 1096

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG16989NP_569860.3 DUF4042 335..511 CDD:463818 63/180 (35%)
HEAT 711..>830 CDD:441023 51/122 (42%)
HEAT repeat 712..745 CDD:293787 12/32 (38%)
HEAT repeat 755..785 CDD:293787 14/29 (48%)
HEAT repeat 800..829 CDD:293787 13/28 (46%)
HEAT repeat 845..875 CDD:293787 10/29 (34%)
HEAT repeat 889..917 CDD:293787 9/27 (33%)
HEAT repeat 928..950 CDD:293787 6/21 (29%)
HEATR6NP_071353.4 HEAT 1 159..198 9/45 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 292..347 13/56 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 371..390 1/18 (6%)
DUF4042 418..599 CDD:463818 63/180 (35%)
HEAT 2 452..490 16/37 (43%)
HEAT 3 515..552 13/36 (36%)
HEAT 4 558..595 9/36 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 613..646 10/46 (22%)
HEAT <775..883 CDD:441023 42/109 (39%)
HEAT repeat 810..843 CDD:293787 10/34 (29%)
HEAT 852..1024 CDD:441023 65/179 (36%)
HEAT repeat 857..886 CDD:293787 14/28 (50%)
HEAT repeat 909..934 CDD:293787 11/24 (46%)
HEAT repeat 957..983 CDD:293787 10/25 (40%)

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