Protein Alignment CG16989 and Heatr6

DIOPT Version :8

• Sequence 1: NP_001284761.1
• Gene: CG16989 / 31026
• FlyBaseID: FBgn0025621
• Length: 940
• Species: Drosophila melanogaster
• Sequence 2: NP_001073366.1
• Gene: Heatr6 / 497972
• RGDID: 1566204
• Length: 1252
• Species: Rattus norvegicus
• Alignment Length: 975
• Identity: 271/976 (28%)
• Similarity: 435/976 (45%)
• Gaps: 153/976 (16%)

  Fly    14 AGFWPRLSALTHAKDMDVALLLLQCQDRVLAELEESPEVAEHNQGLVNSLINMHFEGRWLVAKE- 77
            :|...:||.:||: |.:|....:.|...:...:...|.:.|..|               ||..:
  Rat   236 SGLLMKLSDVTHS-DPEVRRAAVHCMANLCLSVPGQPYLEESYQ---------------LVCFQA 284

  Fly    78 -----QLP-----------LLLAQSLQLIQKLVT--RQPDYAAQRVPELMGLVQCYLQYGAEGET 124
                 |.|           :||..:|:.||.|:.  :......:.:..|:.:::..:.:|..|..
  Rat   285 FLTILQSPKSSDMDDITFCMLLQNALKGIQSLLNGGKMRLTQTEHLGALLAVLKKAMFHGLPGLN 349

  Fly   125 HLKPRKLPPAQQSAAYGQEKEEEDQLLAQMSRPCGRKNKVRKMRSLAKQRNQAVNEHHEPNPRER 189
            ...|..|.|.......|:...:..|..:..:||...|.|..|::....|:.:.. |..||.....
  Rat   350 IEMPAVLYPTPLPQYDGRSPVKPQQPESSAARPSANKKKKYKVKPKKTQQGEKA-EEEEPYGEVD 413

  Fly   190 LV--LMGNQDYGCL-----TGDSGENGLP--------------------------SDSDQQQTEN 221
            ..  |..:|...|:     :...|..|||                          |:||....|.
  Rat   414 AAPGLSMDQANTCVESAWCSSPWGSQGLPVDGGRATGREQVSSPFTISSWKRVSSSESDYSDAEG 478

  Fly   222 KHH---RHQEAKVRISALHLLSTLTNQLPRRSFYGYWHVLFPDGDAGGTPH---LLLLGLKDTNF 280
            ...   |..:||||..||....:....:.::..||||....||....|:|.   |:.|.|||.:.
  Rat   479 GMQGKMRSYQAKVRQGALACFLSTIKSIEKKVLYGYWSAFVPDTPELGSPQSVSLMTLTLKDPSP 543

  Fly   281 RCRALALQVGAQLLYGSKAFLSQA--CSLGPSNFTPFAVSLASSVLTAYRILIAILEREYTPPVL 343
            :.||.||||.:.:|.|||.|||.|  .|.....||||:|::|||:...:|.|:..|..|.:...|
  Rat   544 KTRACALQVLSAILEGSKQFLSVAEDTSDHKRAFTPFSVTIASSIRELHRCLLLALVAESSSQTL 608

  Fly   344 TQCLKCLAVLVQATPFHQLEMGFVYEFVGHVKKLIKSSDPPVAVSALLVMEMLVGTSKLTPEI-- 406
            ||.:||||.||...|:::|::..:.:...|:|..|:..|..|.||:|.::..:|.|....||:
  Rat   609 TQIIKCLANLVSNAPYNRLKLSLLTKVWNHIKPYIRHKDVNVRVSSLTLLGAVVSTHAPLPEVQL 673

  Fly   407 ----ASSIGLAPSQRNLQMEHASTAETYQELCDSDAEMELEEGDEQQQPSQNNVVNPVHTVSPTI 467
                ..|.|.:.|...   .|.||.:.::.|   .|...|||.         ::.:|..|..|
  Rat   674 LLQQPCSSGRSSSSAT---PHLSTPDGWKAL---PAGPSLEEA---------SLSSPKGTAEP-- 721

  Fly   468 PRNSWLLRQVLRCLEGMRI--------------------PSAVRLECFQVLQAMAT-HIGLLRGH 511
               .||:|   .|:..:.:                    ||.:|||..|||..:|. :..:.:.:
  Rat   722 ---CWLIR---LCISTVVLPKEDSCSGSDAGSALGSTYEPSPMRLEALQVLAHLARGYFSMAQLY 780

  Fly   512 QVRLSRVISAGLTDPATDVKLYAARCLDSVGYQL-GRLLPE----PAER---ELQMSFWLTL--- 565
            .:.|..||...:.:....::|:..:.|:.:|..| .:..|:    |.:|   .:...||..:
  Rat   781 LMELGEVICKCMCEANPSIQLHGVKLLEELGTGLIQQYKPDSSTAPEQRVPVHMVAMFWTAMLNG 845

  Fly   566 -LPATYEAYDSAGFSLKCALCDALSNMGAISFERLPDGQRTALLAFLSGCASDDHEETLVRVAAL 629
             ||...::.:..  :|:.:.|||||::...:|..||:.::...:..|.|.  :|.:..||:.|..
  Rat   846 PLPRALQSTEHP--TLQASACDALSSILPEAFSSLPNDKQILCITMLLGL--NDSKNHLVKAATS 906

  Fly   630 RAMAVYVLHPSLRTDLGFVENAAELTLRILGDSQLLARIKAAWALGNISDALVAGI----PNQTE 690
            ||:.||||.|.||.|:.||.:.|...|..|.|..|..|.||||:|||::|.|:..:    |:..:
  Rat   907 RALGVYVLFPCLRQDVIFVADTANAILMSLQDKSLNVRAKAAWSLGNLTDTLIVNMDTPDPSFQD 971

  Fly   691 RISAELLERLIQAATKSCADNDKVRANAVRALGNLLQILQVQPLGN---GELMQVAMSKLLDCVT 752
            ..|..||.:::|:|.::..|.|||::||||||||||..||...:..   .|:::.::..|:..|.
  Rat   972 EFSGLLLLKMLQSAIQASTDKDKVKSNAVRALGNLLHFLQPSHIERPRFAEIIEESIQALISTVV 1036

  Fly   753 LPGNAKVKWNACYVIGNLVKHRAF-FANNRLAGILFPTLCQLVVQHANFKVRTNAAGVLLQVKQR 816
            .....||:|||||.:||:.|:.|. ..........:..|..:|:...|||||..:|..|....:|
  Rat  1037 NEAAMKVRWNACYAMGNVFKNPALPLGTAPWTSQAYKALTSVVMSCKNFKVRIRSAAALSVPGRR 1101

  Fly   817 EDFSA--HFPLLWRSLLDALVRSNVLESFEEYNHRDALQQQLCLAIAHLLLLARSSDLPMMRESL 879
            ..:.:  .|..:|.:|:.||.||.....|.|:.:..:|:..:|.|:.|||.||.:||||.::|:|
  Rat  1102 AQYGSLEQFSQIWSALVTALQRSEDTTDFLEFKYCASLRTHVCQALLHLLGLASASDLPCIQETL 1166

  Fly   880  879
              Rat  1167  1166

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG16989	NP_001284761.1	DUF4042	230..406	CDD:289992	68/181 (38%)
		HEAT repeat	512..543	CDD:293787	6/31 (19%)
		HEAT_2	606..723	CDD:290374	49/121 (40%)
		HEAT repeat	607..640	CDD:293787	13/33 (39%)
		HEAT repeat	650..680	CDD:293787	14/30 (47%)
		ARM	692..810	CDD:237987	43/122 (35%)
		HEAT repeat	695..724	CDD:293787	15/29 (52%)
		HEAT repeat	740..770	CDD:293787	11/30 (37%)
		HEAT repeat	784..812	CDD:293787	9/28 (32%)
		HEAT repeat	823..845	CDD:293787	8/22 (36%)
Heatr6	NP_001073366.1	HEAT 1	230..269		8/34 (24%)
		DUF4042	490..671	CDD:289992	68/181 (38%)
		HEAT 2	524..562		17/38 (45%)
		HEAT 3	586..624		16/38 (42%)
		HEAT 4	630..667		10/37 (27%)
		HEAT repeat	885..914	CDD:293787	11/31 (35%)
		HEAT repeat	928..957	CDD:293787	14/29 (48%)
		HEAT repeat	980..1005	CDD:293787	13/25 (52%)
		HEAT repeat	1028..1054	CDD:293787	11/26 (42%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930				C338209650
eggNOG	1	0.900				E1_KOG2047
Hieranoid	1	1.000
Homologene	1	1.000				H11116
Inparanoid	1	1.050	291	1.000	Inparanoid score	I2656
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010				D106835at2759
OrthoFinder	1	1.000				FOG0007690
OrthoInspector	1	1.000				T1089204
orthoMCL	1	0.900				OOG5_133276
Panther	1	1.100			LDO	PTHR13366
Phylome	0	0.000	Not matched by this tool.
TreeFam	1	0.960
	11	10.850