DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG16989 and Heatr6

DIOPT Version :9

Sequence 1:	NP_001284761.2	Gene:	CG16989 / 31026	FlyBaseID:	FBgn0025621	Length:	1045	Species:	Drosophila melanogaster
Sequence 2:	NP_663407.2	Gene:	Heatr6 / 217026	MGIID:	1919790	Length:	1184	Species:	Mus musculus

Alignment Length:	1116	Identity:	298/1116 - (26%)
Similarity:	485/1116 - (43%)	Gaps:	191/1116 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LEAESRTDQEEADRDSHLQLVREVDHNVGVPVGVAAYRLQQLIAGVRARGHHDLLRLWQLW-LNE 71
            |.|....|...:..:.||...:.:..|.....|||...:..|           |:|..||. ||:
Mouse    37 LRALQPDDSTVSRMEIHLLFDQLISENYSEGGGVAPEDVSAL-----------LVRACQLVPLNQ 90

  Fly    72 LILAKKI------ILVRSHLLIEELLAGTELKPSVE-----TVNLMLTVLKSTPKENL------- 118
            ..|..|:      :|.|..::::|        |:::     |::.:......|..|.|
Mouse    91 NHLVSKVCQLIHRLLNRLQVVVDE--------PNLDFLLTYTISALQQCSSWTHMEILQALAALV 147

  Fly   119 -----------------AGFWPRLSALTHAKDMDVALLLLQCQDRVLAELEESPEVAEHNQGLVN 166
                             :|...:||.|:|: |.:|....:.|...:...:...|.:.|..|
Mouse   148 YCNGSKCQKHLPDLLGKSGLLMKLSDLSHS-DPEVRRAAVHCMANLCLSVPGQPYLEEPYQ---- 207

  Fly   167 SLINMHFEGRWLVAKEQLP-----------LLLAQSLQLIQKLVT--RQPDYAAQRVPELMGLVQ 218
               ::.|:....:.  |.|           :||..:|:.||.|:.  :......:.:..|:.:::
Mouse   208 ---HVCFQAFLTIL--QSPKSSDMDDITFCMLLQNALKGIQSLLNGGKMRLTQTEHLGALLAVLK 267

  Fly   219 CYLQYGAEGETHLKPRKLPPAQQSAAYGQEKEEEDQLLAQMSRPCGRKNKVRKMRSLAKQRNQAV 283
            ..:.:|..|.....|..|.|.......|:...:..|..:..:|....|.|..|:::...|:.:..
Mouse   268 KAMFHGLPGLNIEMPAVLYPTPLPQYDGRSPVKPQQPESTTARSSANKKKKHKVKTKKTQQGEKA 332

  Fly   284 NEHHEPNPRERLVLMG-NQDYGCLTGDS-------GENGLP------------------------ 316
            .|..|....|.....| :.|...::|:|       |..|||
Mouse   333 EEEEEEPCGEVEAAPGLSMDQANVSGESAWCSSPWGSQGLPVDGGRAAGREQASLPFASSSWKRV 397

  Fly   317 --SDSDQQQTENKHH---RHQEAKVRISALHLLSTLTNQLPRRSFYGYWHVLFPDGDAGGTPH-- 374
              |:||....|....   |..:||||..||....:....:.::..||||....||....|:|.
Mouse   398 SSSESDYSDAEGGMQGKMRSYQAKVRQGALACFLSTIKSIEKKVLYGYWSAFVPDTPELGSPQSV 462

  Fly   375 -LLLLGLKDTNFRCRALALQVGAQLLYGSKAFLSQA--CSLGPSNFTPFAVSLASSVLTAYRILI 436
             |:.|.|||.:.:.||.||||.:.:|.|||.|||.|  .|.....||||:|::|||:...:|.|:
Mouse   463 SLMTLTLKDPSPKTRACALQVLSAILEGSKQFLSVAEDTSDHKRAFTPFSVTIASSIRELHRCLL 527

  Fly   437 AILEREYTPPVLTQCLKCLAVLVQATPFHQLEMGFVYEFVGHVKKLIKSSDPPVAVSALLVMEML 501
            ..|..|.:...|||.:||||.||...|:::|::..:.:...|:|..|:..|..|.||:|.::..:
Mouse   528 LALVAESSSQTLTQIIKCLANLVSNAPYNRLKLSLLTKVWNHIKPYIRHKDVNVRVSSLTLLGAI 592

  Fly   502 VGTSKLTPEI------ASSIGLAPSQRNLQMEHASTAETYQELCDSDAEMELEEGDEQQQPSQNN 560
            |.|....||:      ..|.||:.|  :....|.||.:.::..   .|...|||.         :
Mouse   593 VSTHAPLPEVQLLLQQPCSSGLSSS--SSATPHLSTPDGWKTF---PAGSSLEEA---------S 643

  Fly   561 VVNPVHTVSPTIPRNSWLLRQVLRCLEGMRI--------------------PSAVRLECFQVLQA 605
            :.:|..:..|     .||:|   .|:..:.:                    ||.:|||..|||..
Mouse   644 LSSPKGSSEP-----CWLIR---LCISTVVLPKEDSCSGSDAGSALGSTYEPSPMRLEALQVLAH 700

  Fly   606 MAT-HIGLLRGHQVRLSRVISAGLTDPATDVKLYAARCLDSVGYQL-GRLLPE----PAER---E 661
            :|. :....:.:.:.|..||...:.:....::|:..:.|:.:|..| .:..|:    |.:|   .
Mouse   701 LARGYFSTAQLYLMELGEVICKCMCEANPSIQLHGVKLLEELGAGLIQQYKPDSNIAPEQRVPVH 765

  Fly   662 LQMSFWLTLLPATY-EAYDSAGF-SLKCALCDALSNMGAISFERLPDGQRTALLAFLSGCASDDH 724
            |.:.||..:|.... .|..||.. :|:.:.|||||::...:|..||:.::...:..|.|.  :|.
Mouse   766 LVVVFWTAMLSGPLPRALQSAEHPTLQASACDALSSILPEAFSSLPNDKQILCITVLLGL--NDS 828

  Fly   725 EETLVRVAALRAMAVYVLHPSLRTDLGFVENAAELTLRILGDSQLLARIKAAWALGNISDALVAG 789
            :..||:.|..||:.||||.|.||.|:.||.:.|...|..|.|..|..|.||||:|||::|.|:..
Mouse   829 KNHLVKAATSRALGVYVLFPCLRQDVIFVADTANAILMSLQDKSLNVRAKAAWSLGNLTDTLIVN 893

  Fly   790 I----PNQTERISAELLERLIQAATKSCADNDKVRANAVRALGNLLQILQ---VQPLGNGELMQV 847
            :    |:..:..|..||.:::|.|.::..|.|||::||||||||||..||   |:.....|:::.
Mouse   894 MDTPDPSFQDEFSGLLLLKMLQCAIQASTDKDKVKSNAVRALGNLLHFLQPSHVERPRFAEIIEE 958

  Fly   848 AMSKLLDCVTLPGNAKVKWNACYVIGNLVKHRAF-FANNRLAGILFPTLCQLVVQHANFKVRTNA 911
            ::..|:..|......||:|||||.:||:.|:.|. ..........:..|..:|:...|||||..:
Mouse   959 SIQALISTVVNEAAMKVRWNACYAMGNVFKNPALPLGTAPWTSQAYKALTSVVMSCKNFKVRIRS 1023

  Fly   912 AGVLLQVKQREDFSA--HFPLLWRSLLDALVRSNVLESFEEYNHRDALQQQLCLAIAHLLLLARS 974
            |..|....:|..:.:  .|..:|.:|:.||.:|.....|.|:.:..:|:..:|.|:.|||.||.:
Mouse  1024 AAALSVPSKRGQYGSLEQFIQIWSALVTALQKSEDTTDFLEFKYCASLRTHICQALLHLLSLASA 1088

  Fly   975 SDLPMMRESLE 985
            ||||.::|:|:
Mouse  1089 SDLPGIQETLK 1099

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG16989	NP_001284761.2	DUF4042	335..511	CDD:404188	67/180 (37%)
		HEAT repeat	712..745	CDD:293787	12/32 (38%)
		SRP1	721..>830	CDD:227396	48/112 (43%)
		HEAT repeat	755..785	CDD:293787	13/29 (45%)
		HEAT repeat	800..829	CDD:293787	14/28 (50%)
		HEAT repeat	845..875	CDD:293787	10/29 (34%)
		HEAT repeat	889..917	CDD:293787	9/27 (33%)
		HEAT repeat	928..950	CDD:293787	7/21 (33%)
Heatr6	NP_663407.2	HEAT 1	159..198		8/39 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	292..345		10/52 (19%)
		DUF4042	421..602	CDD:289992	67/180 (37%)
		HEAT 2	455..493		16/37 (43%)
		HEAT 3	517..555		15/37 (41%)
		HEAT 4	561..598		10/36 (28%)
		HEAT repeat	817..846	CDD:293787	10/30 (33%)
		HEAT repeat	860..889	CDD:293787	13/28 (46%)
		HEAT repeat	912..937	CDD:293787	12/24 (50%)
		HEAT repeat	960..986	CDD:293787	10/25 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167837955
Domainoid	1	1.000	193	1.000	Domainoid score	I3192
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11116
Inparanoid	1	1.050	293	1.000	Inparanoid score	I2747
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46845
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007369
OrthoInspector	1	1.000	-	-		oto93730
orthoMCL	1	0.900	-	-		OOG6_104402
Panther	1	1.100	-	-	LDO	PTHR13366
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5863
SonicParanoid	1	1.000	-	-		X5488
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	13	12.930