Protein Alignment Mybbp1A and Mybbp1a

DIOPT Version :10

• Sequence 1: NP_476593.2
• Gene: Mybbp1A / 31010
• FlyBaseID: FBgn0001341
• Length: 1133
• Species: Drosophila melanogaster
• Sequence 2: NP_058056.2
• Gene: Mybbp1a / 18432
• MGIID: 106181
• Length: 1344
• Species: Mus musculus
• Alignment Length: 1267
• Identity: 283/1267 - (22%)
• Similarity: 484/1267 - (38%)
• Gaps: 358/1267 - (28%)

  Fly    44 LKKSKKEKPAETEEKENTASNANLKVSQINKAVFVVF-----KKMQGSQL--TKKMINSLITLLR 101
            :|...|.:||...|...:..::.|:.|:    .|:.|     |..|.::|  |:|::..|.|...
Mouse     4 MKSPTKAEPATPAEAAQSDRHSLLEHSR----EFLDFFWDIAKPDQETRLRATEKLLEYLRTRPN 64

  Fly   102 DDTNAEQRTATTGYVLKRLIRSTG-----ADDMKTVSLAASYIHCILNAVPAIDAFEVLETLKRD 161
            |   :|.:     |.|||||...|     |....:::||.     :|.:...|...::|:.::..
Mouse    65 D---SEMK-----YALKRLITGLGVGREAARPCYSLALAQ-----LLQSFEDIPLCDILDQIQEK 116

  Fly   162 LAVGSQQRG-KEDSLAAVGQLVTAFCILQTPQFAKAEPKLVTAV--FQILAA---QLKGREYLVS 220
            .::.:..:. ...||.|  .|.....:.|:.:..|.:..|:.:|  .:||:.   .|:|:.  :.
Mouse   117 YSLQAMNKAMMRPSLFA--NLFGVLALFQSGRLVKDKEALMKSVQLLKILSQHPNHLQGQP--IK 177

  Fly   221 LCGDILAVSFKQLPAAIFEEYVWPLLQPELNKPLSG-LKVNTCDVLLAVHLTFSSVLGRENILAS 284
            ...|||:    ::|.::|:|.        |.|.|.| :||                     ||.|
Mouse   178 ALVDILS----EVPESMFQEI--------LPKVLKGNMKV---------------------ILRS 209

  Fly   285 LWPKKPVYTQLFDLYFSGSTIHSDGVYARLASFLVNGGKDMLAAWQQYIDSKQPLKLNAAKACAI 349
                 |.|.:||       .:....|..:|.|.:  |..|:      :.:...|..:|..|..|.
Mouse   210 -----PKYLELF-------LLAKQRVPTKLESLM--GSVDL------FSEDNIPSLVNILKVAAN 254

  Fly   350 QV-LSHVLLNFKPREEQLILDIFTPTCVQFLLHECS-SVKWDK--GEG--KKPSLKKLKEICFKF 408
            .| ..|.|.|       :.||:     ::..|.|.. .:.|.|  .||  |.||... ..:||:.
Mouse   255 SVKKEHKLPN-------VALDL-----LRLALKESRFELFWKKVLEEGLLKNPSWTS-SYMCFRL 306

  Fly   409 EG-SLVLCYEKQFQNDDNKLHLLLK--LLEHTLQLDSVISLPRFCQKLINQLSVESLHKLYDYYN 470
            .| ||.|..|:|.|       |:::  |:.|..: :.|||.|:...|:|.::|.        |..
Mouse   307 LGASLPLLSEEQLQ-------LVMRGDLIRHFGE-NMVISKPQNLFKIIPEIST--------YVG 355

  Fly   471 NKLYSLEDEDR------VSRVHCLNQ----------MQLILNHSKLSQTAKW-----RQKQLNYL 514
            ..|...:|:.:      |:.....||          :...||...|.....|     .|..||.|
Mouse   356 TFLEGCQDDPKRQLTMMVAFTTITNQGLPVMPTFWRVTRFLNAEALQSYVAWLRDMFLQPDLNSL 420

  Fly   515 ---------------------------------LLAGLFHLDASKKPCEAAQASAF--------S 538
                                             |::.:.||...|......|.:.|        :
Mouse   421 VDFSTANQKRAQDASLNVPERAVFRLRKWIIHRLVSLVDHLHLEKDEAVVEQIARFCLFHAFFKT 485

  Fly   539 RQCAARCEE---------------IFLG---SLLHKCS------------GLPGLCQLLQKTLSY 573
            ::...:..|               :|:.   |||...|            |.|...:|:|.....
Mouse   486 KKATPQIPETKQHFSFPLDDRNRGVFVSAFFSLLQTLSVKFRQTPDLAENGKPWTYRLVQLADML 550

  Fly   574 LNKELGQPDAESKLRSPRDESLQKAWKQ-VEKLLERPSKESDVVGQSFEALILFVSLALCTKIPP 637
            ||.........|.....|     :||.| :..|.|..::.|:....:|:.|:|.|.|.:......
Mouse   551 LNHNRNVTSVTSLTTQQR-----QAWDQMMSTLKELEARSSETRAIAFQHLLLLVGLHIFKSPAE 610

  Fly   638 SITVLEDLIICRKNALQ------KSKEQVNEELKWQDVLTDALLQLLLQTGHFWREFVQLVATAL 696
            |..||.|:..|.|.:::      :|:.:.::|..|.:|:.:.||.||.|..:..|:.|:.|...:
Mouse   611 SCDVLGDIQTCIKKSMEQNPRRSRSRAKASQEPVWVEVMVEILLSLLAQPSNLMRQVVRSVFGHI 675

  Fly   697 IPHLEHGNLEQVLEVLNMNKNPLSKKSD-----------------GEEESDDELDKEESLKDSSD 744
            .|||....|:.:|.||    :|::.:.:                 ||:|..|..|.:.|  :|..
Mouse   676 CPHLTPRCLQLILAVL----SPVTNEDEDDNVVVTDDADEKQLQHGEDEDSDNEDNKNS--ESDM 734

  Fly   745 DSEDEDEDEEEDEGEDDAESHLAQIRESVRQALVNDGDADDDGASSVDWNDVDEEQGERLNAALE 809
            ||||.:|.||||..:|.......|:.|     ::..|:|    ...|| |:.:||.|:....||:
Mouse   735 DSEDGEESEEEDRDKDVDPGFRQQLME-----VLKAGNA----LGGVD-NEEEEELGDEAMMALD 789

  Fly   810 RSF-QMFRPKSRKAQ----EKERPTKSERIDSTNLLHFRIRALDLLELFITKKPTQSVILDVLHC 869
            ::. .:|:.:..:.|    ||.:..|.:::..    .|:||||||:|:.:||:|...:||::|..
Mouse   790 QNLASLFKEQKMRIQARNEEKNKLQKEKKLRR----DFQIRALDLIEVLVTKQPEHPLILELLEP 850

  Fly   870 VFQVYSHC----AADSKLQSLREASLKLLKKILARNIELKENQSTAPILEAIEQLMSSGEEHSEE 930
            :..|..|.    .:..:.|.|...:.::....|.|  ..:......|..||:         |::
Mouse   851 LLNVIQHSMRSKGSTKQEQDLLHKTARIFMHHLCR--ARRYCHEVGPCAEAL---------HAQ- 903

  Fly   931 DQENGKQPASRQAKRDIIIWRDRCFAYLV-------SQASADG---------EPKKSAVWPLLVE 979
             .|...|.|..||...:.::......||:       ::...||         :.:..|...|.::
Mouse   904 -VERLVQQAGSQADASVALYYFNASLYLLRVLKGNTNKRHQDGHKLHGADTEDSEDQAANCLDLD 967

  Fly   980 F--------LELWVAKRRSRLSLASFEALFQSGQWQGVAP-LAVVLASHLDVQKTRSFRRAQILK 1035
            |        ||..:.||.|.|::..|.:||  .::..:.. |..|||.|: ...:|...:||...
Mouse   968 FVTRVYSASLESLLTKRNSSLTVPMFLSLF--SRYPVICKNLLPVLAQHV-AGPSRPRHQAQACL 1029

  Fly  1036 LLSE--QGRRLEVAFKDNNSSSKKFEK----------QIARYVNQLETKASSSKELNLL------ 1082
            :|.:  ..|.|.|.|:|     .::|:          |..:.:.:.::|....|||::|
Mouse  1030 MLQKTLSARELRVCFED-----PEWEQLITQLLGKATQTLQTLGEAQSKGEHQKELSILELLNTL 1089

  Fly  1083 ----------LKILAQGG---EKWQKLREQIQ 1101
                      :.:.|..|   .|.|||::.:|
Mouse  1090 LRTVNHEKLSVDLTAPLGVLQSKQQKLQQSLQ 1121

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mybbp1A	NP_476593.2	DNA_pol_phi	115..854	CDD:461488	200/880 (23%)
Mybbp1a	NP_058056.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..24		5/19 (26%)
		Interaction with MYB. /evidence=ECO:0000269|PubMed:9447996	2..580		143/683 (21%)
		DNA_pol_phi	70..835	CDD:461488	200/880 (23%)
		Nuclear export signal 1. /evidence=ECO:0000269|PubMed:12941609	238..256		4/17 (24%)
		Nuclear export signal 2. /evidence=ECO:0000269|PubMed:12941609	261..279		6/29 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	710..751		16/42 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1146..1344
		DUF612	1149..>1316	CDD:282585
		Required for nuclear and nucleolar localization. /evidence=ECO:0000269|PubMed:12941609	1152..1344