Protein Alignment l(1)sc and ASCL2

DIOPT Version :10

• Sequence 1: NP_476623.1
• Gene: l(1)sc / 30983
• FlyBaseID: FBgn0002561
• Length: 257
• Species: Drosophila melanogaster
• Sequence 2: NP_005161.1
• Gene: ASCL2 / 430
• HGNCID: 739
• Length: 193
• Species: Homo sapiens
• Alignment Length: 228
• Identity: 72/228 - (31%)
• Similarity: 97/228 - (42%)
• Gaps: 63/228 - (27%)

  Fly    39 APKIPLGTSQLQNMQQSQQSNVGPMLSSQKKKFNYNNMPYGEQLPSVARRNARERNRVKQVNNGF 103
            ||.:|:|.:       :::....|.|....::........|....:|||||.|||||||.||.||
Human    13 APPVPVGCA-------ARRRPASPELLRCSRRRRPATAETGGGAAAVARRNERERNRVKLVNLGF 70

  Fly   104 VNLRQHLPQTVVNSLSNGGRGSSKKLSKVDTLRIAVEYIRGLQDMLDDGTASSTRHIYNSADESS 168
            ..||||:|.          .|:|||||||:|||.||||||.||.:|
Human    71 QALRQHVPH----------GGASKKLSKVETLRSAVEYIRALQRLL------------------- 106

  Fly   169 NDGSSYNDYNDSL----------DSSQQFLTGATQSAQSHSYHSASPTPSYSGSEISGGGYIKQE 223
               :.::...::|          .|:.:...|.|..|.|.|  .||.:|...||...|
Human   107 ---AEHDAVRNALAGGLRPQAVRPSAPRGPPGTTPVAASPS--RASSSPGRGGSSEPG------- 159

  Fly   224 LQEQDLKFDSFDSFSDE--QPDDEELLDYISSW 254
              .....:.|.||..:.  .|.:.||||: |||
Human   160 --SPRSAYSSDDSGCEGALSPAERELLDF-SSW 189

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
l(1)sc	NP_476623.1	bHLH_TS_dAS-C_like	94..149	CDD:381587	32/54 (59%)
ASCL2	NP_005161.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..27		4/20 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	37..56		4/18 (22%)
		bHLH_TS_ASCL2_Mash2	49..112	CDD:381586	41/94 (44%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	118..177		15/69 (22%)