Protein Alignment sc and ATOH1

DIOPT Version :10

• Sequence 1: NP_476803.1
• Gene: sc / 30982
• FlyBaseID: FBgn0004170
• Length: 345
• Species: Drosophila melanogaster
• Sequence 2: NP_005163.1
• Gene: ATOH1 / 474
• HGNCID: 797
• Length: 354
• Species: Homo sapiens
• Alignment Length: 276
• Identity: 69/276 - (25%)
• Similarity: 93/276 - (33%)
• Gaps: 96/276 - (34%)

  Fly    70 RGMALTRCSESVSSLSPGSSPAPYNVDQ-----------------------SQSV-----QRR-- 104
            ||..:.|.|...||   ..||.|..|.:                       |:.|     |||
Human   102 RGELVRRSSGGASS---SKSPGPVKVREQLCKLKGGVVVDELGCSRQRAPSSKQVNGVQKQRRLA 163

  Fly   105 -NARERNRVKQVNNSFARLRQHIPQSIITDLTKGGGRGPHKKISKVDTLRIAVEYIRRLQDLVDD 168
             |||||.|:..:|::|.:||..|| |...|          ||:||.:||::|..||..|.:|:..
Human   164 ANARERRRMHGLNHAFDQLRNVIP-SFNND----------KKLSKYETLQMAQIYINALSELLQT 217

  Fly   169 LNGGSN------------------------------IGANNAVTQLQLCLDESSSHSSSSSTCSS 203
            .:||..                              .||..|....|......|..:..|:..|:
Human   218 PSGGEQPPPPPASCKSDHHHLRTAASYEGGAGNATAAGAQQASGGSQRPTPPGSCRTRFSAPASA 282

  Fly   204 SGHNTYYQNTISVSPLQQQQQLQRQQFNHQPLTALSLNTNLVGTSVPGGDAGCV--STSKNQQTC 266
            .|::.            |...|....|....|||:....|| ..|:||.....|  ..||.....
Human   283 GGYSV------------QLDALHFSTFEDSALTAMMAQKNL-SPSLPGSILQPVQEENSKTSPRS 334

  Fly   267 H------SPTSSFNSS 276
            |      ||.|.::.|
Human   335 HRSDGEFSPHSHYSDS 350

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sc	NP_476803.1	bHLH_TS_dAS-C_like	100..166	CDD:381587	28/73 (38%)
ATOH1	NP_005163.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..55
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	91..122		8/22 (36%)
		bHLH_TS_ATOH1	155..218	CDD:381556	28/73 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	216..277		7/60 (12%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	312..354		11/39 (28%)