Protein Alignment VSX1 and E5

DIOPT Version :10

• Sequence 1: NP_055403.2
• Gene: VSX1 / 30813
• HGNCID: 12723
• Length: 365
• Species: Homo sapiens
• Sequence 2: NP_524825.1
• Gene: E5 / 45396
• FlyBaseID: FBgn0008646
• Length: 524
• Species: Drosophila melanogaster
• Alignment Length: 408
• Identity: 89/408 - (21%)
• Similarity: 126/408 - (30%)
• Gaps: 149/408 - (36%)

Human     4 RDSLSDGRTSSRALV---PGGSPRGSRPRGFAITDLLGLEAELPAPAG-PGQGSGCEGPAVAPCP 64
            ||||...|:..|:.|   |.....|..|.....|          |.:| |..|:|.....:.|.|
  Fly   106 RDSLDRSRSPQRSPVSRSPSPPNAGGNPAAAGNT----------AKSGDPSSGTGNPPTLIRPLP 160

Human    65 GPGLDGSSLARGALPLGLGLLCGFGTQPPAAARAPCLLLAD------------------------ 105
            .|..:.:.:.....|..:.:.......||  ::.|..|.|.
  Fly   161 LPAPNLALIGNRTSPNAMAVRMAGPPHPP--SQPPPFLAAQFQMAAALAHHHQQQQQQQQQQLPP 223

Human   106 VPFLPPRGPEPAAPLA------------PSRPPPALGRQKRSDSVSTSDEDSQSEDRNDLKASPT 158
            ||..||.||.|..|..            |..|||                    ...:...::|.
  Fly   224 VPTGPPHGPHPHLPPGQIPLGIFPGGPHPGHPPP--------------------HGHHPFGSAPH 268

Human   159 L---------------GK--------------RKKRRHRTVFTAHQLEELEKAFSEAHYPDVYAR 194
            |               |:              ||.:|.||.|:..||.:||.||...||.....|
  Fly   269 LIRDSYPLYPWLLSRHGRIFPRFPGNFLFQPFRKPKRVRTAFSPTQLLKLEHAFEGNHYVVGAER 333

Human   195 EMLAVKTELPEDRIQVWFQNRRAKWRKREKRWG-GSSVMAEYGLYGAMVRHCIPLPDSVLNSAEG 258
            :.||....|.|.:::|||||||.|.::.::..| ||...:..|                 :|:.|
  Fly   334 KQLAQGLSLTETQVKVWFQNRRTKHKRMQQEGGDGSDTKSNKG-----------------SSSGG 381

Human   259 GLLGSCAPWLLGMHKKSMGMIRKPGSEDKLAGLWGSDHFK-EGSSQSESGSQRGSDKVSPENGLE 322
            |                       |..|      |.|..| :||..|...::...|:...|...|
  Fly   382 G-----------------------GGGD------GEDDAKHDGSQHSYEDAEDPEDEDEIEEDDE 417

Human   323 DVAIDLSSSARQETKKVH 340
            |..||:.....:...:.|
  Fly   418 DEVIDMDDYGSEMDAEEH 435

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
VSX1	NP_055403.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..37		11/35 (31%)
		Octapeptide motif	31..38		1/6 (17%)
		PRK14959	<47..>149	CDD:184923	25/138 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	113..167		13/94 (14%)
		Nuclear localization signal. /evidence=ECO:0000255	161..166		2/18 (11%)
		Homeodomain	165..221	CDD:459649	25/55 (45%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	290..365		13/52 (25%)
E5	NP_524825.1	Homeodomain	304..360	CDD:459649	25/55 (45%)