Protein Alignment VSX1 and Gsc

DIOPT Version :10

• Sequence 1: NP_055403.2
• Gene: VSX1 / 30813
• HGNCID: 12723
• Length: 365
• Species: Homo sapiens
• Sequence 2: NP_001137762.2
• Gene: Gsc / 33240
• FlyBaseID: FBgn0010323
• Length: 473
• Species: Drosophila melanogaster
• Alignment Length: 351
• Identity: 94/351 - (26%)
• Similarity: 124/351 - (35%)
• Gaps: 96/351 - (27%)

Human     5 DSLSDGRTSSRALVP--------GGSPRGSRPRGFAITDLLGLE---AELPAPAGPGQGSGCEGP 58
            ||:...|.......|        .|:..|....|.:    |||:   ||.||.......|.....
  Fly   167 DSILGSRQQGGGTAPSQGSHISSNGNQNGLTSNGIS----LGLKRSGAESPASPNSNSSSSAAAS 227

Human    59 AVAP--CPG----PGLDGSSLARGALPLGLGLLCGFGTQPP----------------------AA 95
            .:.|  .|.    |||....||..|       ..||...|.                      ||
  Fly   228 PIRPQRVPAMLQHPGLHLGHLAAAA-------ASGFAASPSDFLVAYPNFYPNYMHAAAVAHVAA 285

Human    96 ARAPCLLLADVPFLPPRGPEPAAPLAPSRP-PPALGRQKRSDSVSTSDEDSQSEDRNDLKASPTL 159
            |:....:......|...|..|..|  ...| .|.||.....           ....:.|...|.
  Fly   286 AQMQAHVSGAAAGLSGHGHHPHHP--HGHPHHPHLGAHHHG-----------QHHLSHLGHGPP- 336

Human   160 GKRKKRRHRTVFTAHQLEELEKAFSEAHYPDVYAREMLAVKTELPEDRIQVWFQNRRAKWRKREK 224
             .::||||||:||..|||:||..|.:.|||||..||.||:|.:|.|:|::|||:||||||||:::
  Fly   337 -PKRKRRHRTIFTEEQLEQLEATFDKTHYPDVVLREQLALKVDLKEERVEVWFKNRRAKWRKQKR 400

Human   225 RWGGSSVMAEYGLYGAMVRHCIPLPDSVLNSAEGGLLGSCAPWLLGMHKKSMG----MIRKPGSE 285
            .       .:..|.......|....:...||:.|             ...|.|    .::.|||:
  Fly   401 E-------EQERLRKLQEEQCGSTTNGTTNSSSG-------------TTSSTGNGSLTVKCPGSD 445

Human   286 DKLAGLWGSDHFK---EGSSQSESGS 308
            ...|.|   .|.|   .|.|.::..|
  Fly   446 HYSAQL---VHIKSDPNGYSDADESS 468

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
VSX1	NP_055403.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..37		7/39 (18%)
		Octapeptide motif	31..38		0/6 (0%)
		PRK14959	<47..>149	CDD:184923	23/130 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	113..167		11/54 (20%)
		Nuclear localization signal. /evidence=ECO:0000255	161..166		1/4 (25%)
		Homeodomain	165..221	CDD:459649	35/55 (64%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	290..365		6/22 (27%)
Gsc	NP_001137762.2	Homeodomain	341..397	CDD:459649	35/55 (64%)