DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Thg1l and THG

DIOPT Version :9

Sequence 1:	NP_001013988.1	Gene:	Thg1l / 303067	RGDID:	1359513	Length:	298	Species:	Rattus norvegicus
Sequence 2:	NP_001188815.1	Gene:	THG / 34876	FlyBaseID:	FBgn0283659	Length:	286	Species:	Drosophila melanogaster

Alignment Length:	265	Identity:	150/265 - (56%)
Similarity:	188/265 - (70%)	Gaps:	19/265 - (7%)

- Green bases have known domain annotations that are detailed below.

  Rat    30 MAKSKFEYVRDFEVDDTCLPHCWVVVRLDGRNFHRFAEKHNFAKPNDSRALHLMTKCAQTVMQEL 94
            ||.|:||||:.||.||:.||:.|:|:|:||:.||:|::.|:|.||||..||::|...|..||||.
  Fly     1 MACSRFEYVKSFEQDDSILPNVWIVIRIDGKKFHKFSKTHDFEKPNDENALNVMNAAATAVMQEF 65

  Rat    95 EDIVIAYGQSDEYSFVFRKRSNWFKRRASKFMTLVASQFASSYVFYWRDYFEDQPLLYPPGFDGR 159
            .|||:||||||||||||||.:..||||::|.:|.|.|.|:||||..|..:. :.||.|.|.||||
  Fly    66 RDIVLAYGQSDEYSFVFRKETAAFKRRSAKLLTYVTSLFSSSYVMQWSKWM-NLPLAYAPCFDGR 129

  Rat   160 VVLYPSNQTLKDYLSWRQADCHINNLYNTVFWALIQQSGLTPVQAQQRLKGTLTADKNEILFSEF 224
            ||||||.|.|||||||||||.|:||||||.||.|:.:.|||..||:.:|:||.:|||||:||.||
  Fly   130 VVLYPSEQNLKDYLSWRQADVHVNNLYNTAFWKLVLEKGLTNQQAEAKLRGTFSADKNELLFQEF 194

  Rat   225 HINYNNEPHMYRKGTVLVWQKVNEVRTQEIRLPAEMEGEKMAVTRTRTKLVALNCDLIGDAFWKE 289
            .|||||.|.||||||:|:.::|             :.|||     :|..:|.|:.|||...||||
  Fly   195 GINYNNLPAMYRKGTILLRKRV-------------ILGEK-----SRQAVVPLHEDLISSQFWKE 241

  Rat   290 HPEIL 294
            |.|||
  Fly   242 HTEIL 246

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Thg1l	NP_001013988.1	Thg1	31..291	CDD:226508	145/259 (56%)
THG	NP_001188815.1	Thg1	2..239	CDD:226508	141/255 (55%)
		Thg1	9..134	CDD:282322	71/125 (57%)
		Thg1C	137..234	CDD:291110	60/114 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353451
Domainoid	1	1.000	164	1.000	Domainoid score	I3868
eggNOG	1	0.900	-	-		E1_COG4021
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5959
Inparanoid	1	1.050	301	1.000	Inparanoid score	I2603
OMA	1	1.010	-	-		QHG54375
OrthoDB	1	1.010	-	-		D1152974at2759
OrthoFinder	1	1.000	-	-		FOG0004478
OrthoInspector	1	1.000	-	-		oto95651
orthoMCL	1	0.900	-	-		OOG6_103009
Panther	1	1.100	-	-	LDO	PTHR12729
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3173
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770