DRSC/TRiP Functional Genomics Resources

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Protein Alignment tncb and Ten-m

DIOPT Version :10

Sequence 1:NP_001299845.1 Gene:tncb / 30037 ZFINID:ZDB-GENE-980526-104 Length:1811 Species:Danio rerio
Sequence 2:NP_001262211.1 Gene:Ten-m / 40464 FlyBaseID:FBgn0004449 Length:3349 Species:Drosophila melanogaster


Alignment Length:1773 Identity:390/1773 - (21%)
Similarity:593/1773 - (33%) Gaps:595/1773 - (33%)


- Green bases have known domain annotations that are detailed below.


Zfish   287 CPNDCFDRGRCENGTCYCDEGFTGEDCGELTCPQNCNHHGRCVNGQCICNIGYSGEDCSKL--TC 349
            |||.|...|:|..|.|.|:.||.|:||.|..||..|:.||...||:||||.|:.|::||..  .|
  Fly  1071 CPNGCSGNGQCLLGHCQCNPGFGGDDCSESVCPVLCSQHGEYTNGECICNPGWKGKECSLRHDEC 1135

Zfish   350 -LNDCSERGHCFNGKCICDPGFEGEDCSLLSCP-DNCNGRGHCVNGECICGPGYEGDDCS----- 407
             :.|||..|||.:|||.|..|::|:.|..:.|| .||:|.|.|.:|.|||..|::|.||:     
  Fly  1136 EVADCSGHGHCVSGKCQCMRGYKGKFCEEVDCPHPNCSGHGFCADGTCICKKGWKGPDCATMDQD 1200

Zfish   408 ELSCLNNCHDRGR--CVNGKCICKAGFAGEDCSIKTCPHDCHGRGECVDGKCVCHDGFAGEHCGI 470
            .|.||.:|...|.  .....|.|:|.::|:|||.:.|..||...|.|....|.|...:.||:|..
  Fly  1201 ALQCLPDCSGHGTFDLDTQTCTCEAKWSGDDCSKELCDLDCGQHGRCEGDACACDPEWGGEYCNT 1265

Zfish   471 KTCPHHCHGHGQCVDGKCICHKGFAGEDCSIKTCPNHCHGQGQC-IDG----KCICHDGFAGEDC 530
            :.|...|:.||||.:|.|:|..|:.|:.|:|:.|||.|.|.||| :.|    :|.|::|:.|.||
  Fly  1266 RLCDVRCNEHGQCKNGTCLCVTGWNGKHCTIEGCPNSCAGHGQCRVSGEGQWECRCYEGWDGPDC 1330

Zfish   531 SIKTCPNHCHGRGRCVDGKCICHDGFAGEDCNIKTCPNDCHDHGECVDGKCICHAGFTGHDCSEL 595
            .|....|       |.|.|....||..           ||.| .||    |..|...|...|...
  Fly  1331 GIALELN-------CGDSKDNDKDGLV-----------DCED-PEC----CASHVCKTSQLCVSA 1372

Zfish   596 TCPNDC---------------------------------------------HNRGRCVNGQCVCN 615
            ..|.|.                                             .:|...:.|:.|.:
  Fly  1373 PKPIDVLLRKQPPAITASFFERMKFLIDESSLQNYAKLETFNESIFWNYFNASRSAVIRGRVVTS 1437

Zfish   616 I--GFTGEDCGTKTCPNNCLDRGFCEDGKCVCFEGYTGEDCSVLTCPADCNDQG---QCLNGMCI 675
            :  |..|....|.|                 ..||:|      ||     .|.|   ..:||...
  Fly  1438 LGMGLVGVRVSTTT-----------------LLEGFT------LT-----RDDGWFDLMVNGGGA 1474

Zfish   676 CDLGFTGDDCSEISPPRDLTVTEVDPET--VDVAWVNEMLVTEYLITYVPTAPGGLEMEMRVSGE 738
            ..|.|..      :|.|        |::  |.|.| ||:::.:.::             |.:|.|
  Fly  1475 VTLQFGR------APFR--------PQSRIVQVPW-NEVVIIDLVV-------------MSMSEE 1511

Zfish   739 K------------------KTATIRELEPGIE-------YLISVFAVLNSKMSVP--------VS 770
            |                  |...:...:.|.:       .:::...|:...:.:|        .|
  Fly  1512 KGLAVTTTHTCFAHDYDLMKPVVLASWKHGFQGACPDRSAILAESQVIQESLQIPGTGLNLVYHS 1576

Zfish   771 ARIATHL--------PEP--------------EGLKFKSVKETSVEVE----WDPLNI------- 802
            :|.|.:|        |:.              ||:.|:.:.|....::    |:.|||       
  Fly  1577 SRAAGYLSTIKLQLTPDVIPTSLHLIHLRITIEGILFERIFEADPGIKFTYAWNRLNIYRQRVYG 1641

Zfish   803 -----------------------------------PFDGWNLIFRNTKEEDGEILNSLAPPETTF 832
                                               ...||||...:.......||          
  Fly  1642 VTTAVVKVGYQYTDCTDIVWDIQTTKLSGHDMSISEVGGWNLDIHHRYNFHEGIL---------- 1696

Zfish   833 EQSGLGPGQEYEVKLEVVKNNTRGPPASKNVVTMIDAPSQ-VDVRDVTDTTALVTWLQPVAQV-- 894
             |.|.|.......|..::            :.||.|...: ::..|..........|.|||..  
  Fly  1697 -QKGDGSNIYLRNKPRII------------LTTMGDGHQRPLECPDCDGQATKQRLLAPVALAAA 1748

Zfish   895 -DGISVSYGP-------NTDSSDRNTIELSS--IETQYHLAELSP--------DTEYEVSLMARR 941
             || |:..|.       .||.|.|..::|::  :..:||:| |||        |.|....:..|.
  Fly  1749 PDG-SLFVGDFNYIRRIMTDGSIRTVVKLNATRVSYRYHMA-LSPLDGTLYVSDPESHQIIRVRD 1811

Zfish   942 GEMSSFPIYETFTTDLDSPKHLKAIEQTDESITLEWRNSRANVLNYRVKYGP----LSGGE---- 998
                        |.|...|:                       ||:....|.    |.|.|    
  Fly  1812 ------------TNDYSQPE-----------------------LNWEAVVGSGERCLPGDEAHCG 1841

Zfish   999 ------HGELVFPSGLQDTTQAKITGLRPGTEYGM----GVTSI-------KEERESLPATTNAV 1046
                  ..:|.:|.|:..::. .|.....||...|    |:.|.       |...:.:|......
  Fly  1842 DGALAKDAKLAYPKGIAISSD-NILYFADGTNIRMVDRDGIVSTLIGNHMHKSHWKPIPCEGTLK 1905

Zfish  1047 TD---LDPPKDLQVSETTETTLALVWRRPVAKIDTYSLVFIPADGDKTELKIPGAANTYILTGLN 1108
            .:   |..|.:|.|| ..:.||.:        ||.:.::.:..||           ...:::| .
  Fly  1906 LEEMHLRWPTELAVS-PMDNTLHI--------IDDHMILRMTPDG-----------RVRVISG-R 1949

Zfish  1109 PGMLHTITLTAERGRKMSAPATLSASTDEEKPQVGNITISDVSWDSFSMSWDLDRGEVEGFLIEV 1173
            |  ||..|.:......::..|||..........:|.:.:::      |.|..::|..|.|     
  Fly  1950 P--LHCATASTAYDTDLATHATLVMPQSIAFGPLGELYVAE------SDSQRINRVRVIG----- 2001

Zfish  1174 SDPDGLSDGQNHTLSGQEFSLAVTDLSPSTF----YRVTLYGLYKGELLDPVFAEAITEAEPEVE 1234
                  :||:....:|.|......:.....|    |..|      ....:.:.|.|:|   |: .
  Fly  2002 ------TDGRIAPFAGAESKCNCLERGCDCFEAEHYLAT------SAKFNTIAALAVT---PD-S 2050

Zfish  1235 HITVSDITPHSFK-VTWTAPEA-----------------VFDSFALKVLDSSGLGRPHQISVSGD 1281
            |:.::|...:..: |..:.|||                 :|:.|...|                 
  Fly  2051 HVHIADQANYRIRSVMSSIPEASPSREYEIYAPDMQEIYIFNRFGQHV----------------- 2098

Zfish  1282 KRTEAVTGLNEDTDYEIELFGIILGRKFQPIFTVARTGLGTPKGIRFSDVTDTSATVHWTMPHTR 1346
            .....:||   :|.|               :||.   .:.|..| :.|.|||.:           
  Fly  2099 STRNILTG---ETTY---------------VFTY---NVNTSNG-KLSTVTDAA----------- 2130

Zfish  1347 VDNYRVIYVPIQGGSPLTLRVDGGESQAMLSNLTPGVTYQVTVIAVKGLEE-SEPGSERVTTALD 1410
                         |:.:.|..|.......:.| |.|...::.:..:|.|.| |.|.:..||....
  Fly  2131 -------------GNKVFLLRDYTSQVNSIEN-TKGQKCRLRMTRMKMLHELSTPDNYNVTYEYH 2181

Zfish  1411 KPRGLTAVNISDTEALLLWQ-------PSIATVDGYVITYSAD-SVAPVMERVSGNTVEFEMSSL 1467
            .|.||....:..|....::.       .|..|..|.||..|.| ||.....:||.| .:.|||.|
  Fly  2182 GPTGLLRTKLDSTGRSYVYNYDEFGRLTSAVTPTGRVIELSFDLSVKGAQVKVSEN-AQKEMSLL 2245

Zfish  1468 TPATLYTVKVYAFRDTAKSAATSTDFTTDVDAPQNLAASNIQTETAMLTWKPPRADISGYILSFE 1532
            .......|         ::.|..:..|.|:|.          :.|::..|        |:.|..|
  Fly  2246 IQGATVIV---------RNGAAESRTTVDMDG----------STTSITPW--------GHNLQME 2283

Zfish  1533 SADGVVKEVVLSPTATFYSMSQLTASTEYTVKLQAIAGPKRSRVISTVF------LTIGVLYKHP 1591
                |....:|:..:.....|....:.:.|    .|||...:|.....|      |..|...|.|
  Fly  2284 ----VAPYTILAEQSPLLGESYPVPAKQRT----EIAGDLANRFEWRYFVRRQQPLQAGKQSKGP 2340

Zfish  1592 ----KDCSQAL-LNGDTTSGL------YTIYLRGDESQPLQVYCDMTTDGGGWIVFVRRQSG--- 1642
                .:..:.| :|||....|      .::.:..|:.|.|   .::|.|.....:..|.|||   
  Fly  2341 PRPVTEVGRKLRVNGDNVLTLEYDRETQSVVVMVDDKQEL---LNVTYDRTSRPISFRPQSGDYA 2402

Zfish  1643 --KVEFFR-----NWK----NYTAGF---GDLND-EFWLGLSNLHKITS-FGQYELRVDLRDKGE 1691
              .:|:.|     :||    .....|   |.||: ::..|.:.::.... ||...|:|....:.:
  Fly  2403 DVDLEYDRFGRLVSWKWGVLQEAYSFDRNGRLNEIKYGDGSTMVYAFKDMFGSLPLKVTTPRRSD 2467

Zfish  1692 SAYAQYDKF----SISEPRARYKVHVGGYS-GTAGDSMTYHH-----GRPFSTYDNDND--IAVT 1744
             ...|||..    |::.||.    |:..:| .|:.....|.:     ..||....||..  :|..
  Fly  2468 -YLLQYDDAGALQSLTTPRG----HIHAFSLQTSLGFFKYQYYSPINRHPFEILYNDEGQILAKI 2527

Zfish  1745 NCALSYKGAFWYKNCHRV 1762
            :...|.|.||.:....|:
  Fly  2528 HPHQSGKVAFVHDTAGRL 2545

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
tncbNP_001299845.1 EGF_Tenascin 225..252 CDD:480934
EGF_Tenascin 256..283 CDD:480934
EGF_Tenascin 318..345 CDD:480934 13/26 (50%)
EGF_Tenascin 380..407 CDD:480934 14/27 (52%)
PRK10767 <471..>544 CDD:236757 30/77 (39%)
EGF_Tenascin 535..562 CDD:480934 6/26 (23%)
EGF_Tenascin 566..593 CDD:480934 8/26 (31%)
EGF_Tenascin 597..623 CDD:480934 7/72 (10%)
EGF_Tenascin 628..655 CDD:480934 3/26 (12%)
EGF_Tenascin 659..686 CDD:480934 6/29 (21%)
FN3 <689..>908 CDD:442628 53/332 (16%)
FN3 <853..1296 CDD:442628 94/513 (18%)
FN3 <1333..>1568 CDD:442628 48/243 (20%)
FReD 1589..1798 CDD:238040 49/216 (23%)
Ten-mNP_001262211.1 EGF_Tenascin 1071..1098 CDD:480934 13/26 (50%)
EGF_2 1139..1162 CDD:400365 12/22 (55%)
DUF5885 <1181..1229 CDD:437064 16/47 (34%)
EGF_2 1272..1294 CDD:400365 10/21 (48%)
acid_disulf_rpt 1337..1363 CDD:411265 13/48 (27%)
NHL 1750..2065 CDD:302697 76/402 (19%)
NHL repeat 1784..1830 CDD:271323 15/81 (19%)
NHL repeat 1854..1888 CDD:271323 8/34 (24%)
NHL repeat 1911..1950 CDD:271323 12/59 (20%)
NHL repeat 1972..2005 CDD:271323 7/49 (14%)
NHL repeat 2039..2065 CDD:271323 6/29 (21%)
RHS_repeat 2183..2217 CDD:461685 6/33 (18%)
RhsA <2248..2980 CDD:442442 70/341 (21%)
Tox-GHH 3191..3268 CDD:464783
Blue background indicates that the domain is not in the aligned region.

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