DRSC/TRiP Functional Genomics Resources

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Protein Alignment UBQLN2 and DSK2

DIOPT Version :10

Sequence 1:NP_038472.2 Gene:UBQLN2 / 29978 HGNCID:12509 Length:624 Species:Homo sapiens
Sequence 2:NP_014003.1 Gene:DSK2 / 855319 SGDID:S000004889 Length:373 Species:Saccharomyces cerevisiae


Alignment Length:609 Identity:136/609 - (22%)
Similarity:211/609 - (34%) Gaps:264/609 - (43%)


- Green bases have known domain annotations that are detailed below.


Human    33 IKVTVKTPKEKEEFAVPENSSVQQFKEAISKRFKSQTDQLVLIFAGKILKDQDTLIQHGIHDGLT 97
            :.:.:|:.::|.|..|...|:|.||||||:|..........||::||||||..|:..:.|.||.:
Yeast     3 LNIHIKSGQDKWEVNVAPESTVLQFKEAINKANGIPVANQRLIYSGKILKDDQTVESYHIQDGHS 67

Human    98 VHLVIKSQNRPQGQSTQPSNAAGTN--TTSASTPRSNSTPISTNSNPFGLGSL--------GGLA 152
            |||| |||.:|     |.::|||.|  |.:.:...:.:||..::....|...|        .|..
Yeast    68 VHLV-KSQPKP-----QTASAAGANNATATGAAAGTGATPNMSSGQSAGFNPLADLTSARYAGYL 126

Human   153 GLSSLGLSSTNFSELQSQMQQQLMASPEMMIQIMENPFVQS----MLSNPDLMRQLIMANPQMQ- 212
            .:.|..:...:...|.:....|     :.::::||||..||    |||||.::..:|.:|||:| 
Yeast   127 NMPSADMFGPDGGALNNDSNNQ-----DELLRMMENPIFQSQMNEMLSNPQMLDFMIQSNPQLQA 186

Human   213 ------QLIQRNPEISHLLNNPDIMRQTLEIARNPAMMQEMMRNQDLALSNLESIPGGYNALRRM 271
                  |::| :|....:|.|||::||:::.||       ||                       
Yeast   187 MGPQARQMLQ-SPMFRQMLTNPDMIRQSMQFAR-------MM----------------------- 220

Human   272 YTDIQEPMLNAAQEQFGGNPFASVGSSSSSGEGTQPSRTENRDPLPNPWAPPPATQSSATTSTTT 336
                              :|.|.:||:..:...           .|.|....|...|:..|::::
Yeast   221 ------------------DPNAGMGSAGGAASA-----------FPAPGGDAPEEGSNTNTTSSS 256

Human   337 STGSGSG-NSSSNATGNTVAAANYVASIFSTPGMQSLLQQITENPQLIQNMLSAPYMRSMMQSLS 400
            :||:.:| |:.:||..||  |||..||:.              ||.|                  
Yeast   257 NTGNNAGTNAGTNAGANT--AANPFASLL--------------NPAL------------------ 287

Human   401 QNPDLAAQMMLNSPLFTANPQLQEQMRPQLPAFLQQMQNPDTLSAMSNPRAMQALMQIQQGLQTL 465
                        :|...|.......|    |||     :|..|::|..|                
Yeast   288 ------------NPFANAGNAASTGM----PAF-----DPALLASMFQP---------------- 315

Human   466 ATEAPGLIPSFTPGVGVGVLGTAIGPVGPVTPIGPIGPIVPFTPIGPIGPIGPTGPAAPPGSTGS 530
                                        ||                                   
Yeast   316 ----------------------------PV----------------------------------- 317

Human   531 GGPTGPTVSSAAPSETTSPTSESGPNQQFIQQMVQALAGANAPQLPNPEVRFQQQLEQLNAMGFL 595
                     .|:.:|.|.|                            ||.|::.||.|||.|||.
Yeast   318 ---------QASQAEDTRP----------------------------PEERYEHQLRQLNDMGFF 345

Human   596 NREANLQALIATGGDINAAIERLL 619
            :.:.|:.||..:||.:..|::.||
Yeast   346 DFDRNVAALRRSGGSVQGALDSLL 369

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
UBQLN2NP_038472.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..32
Ubl_PLICs 31..103 CDD:340506 29/69 (42%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 106..141 9/36 (25%)
STI1 182..215 CDD:128966 17/43 (40%)
STI1 208..253 CDD:450205 17/51 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 287..349 13/62 (21%)
STI1 382..426 CDD:128966 3/43 (7%)
12 X 3 AA tandem repeats of P-X-X 491..526 2/34 (6%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 512..556 4/43 (9%)
UBA_PLICs 581..620 CDD:270582 17/39 (44%)
DSK2NP_014003.1 Ubl_Dsk2p_like 3..74 CDD:340523 30/71 (42%)
STI1 149..185 CDD:128966 15/35 (43%)
UBA_Dsk2p_like 328..369 CDD:270509 17/40 (43%)
Blue background indicates that the domain is not in the aligned region.

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