Protein Alignment UBQLN2 and ubqln1

DIOPT Version :8

• Sequence 1: NP_038472.2
• Gene: UBQLN2 / 29978
• HGNCID: 12509
• Length: 624
• Species: Homo sapiens
• Sequence 2: NP_989221.1
• Gene: ubqln1 / 394829
• XenbaseID: XB-GENE-986025
• Length: 564
• Species: Xenopus tropicalis
• Alignment Length: 612
• Identity: 426/613 (69%)
• Similarity: 491/613 (80%)
• Gaps: 56/613 (9%)

Human    17 PAAAQGSAAAPAEPKIIKVTVKTPKEKEEFAVPENSSVQQFKEAISKRFKSQTDQLVLIFAGKIL 81
            |:::..|::.||  :||||||||||||||||||||||:::|||.|||||||.|:|||||||||||
 Frog     5 PSSSTPSSSDPA--RIIKVTVKTPKEKEEFAVPENSSIREFKEDISKRFKSSTEQLVLIFAGKIL 67

Human    82 KDQDTLIQHGIHDGLTVHLVIKSQNRPQGQSTQPSNAAGTNTTSASTPRSNSTPISTNSNPFGLG 146
            ||||||.|||||||||||||||:|||.|..:...::::.|:.|:::|..|::|..:|...|.|||
 Frog    68 KDQDTLSQHGIHDGLTVHLVIKTQNRSQAATASQASSSSTSATNSTTSSSSTTTTTTTGTPLGLG 132

Human   147 SLGGLAGLSSLGLSSTNFSELQSQMQQQLMASPEMMIQIMENPFVQSMLSNPDLMRQLIMANPQM 211
            .|||||||||||::::||||||||||||||::||||:||||||||||||||||||.|||||||||
 Frog   133 GLGGLAGLSSLGMNASNFSELQSQMQQQLMSNPEMMVQIMENPFVQSMLSNPDLMSQLIMANPQM 197

Human   212 QQLIQRNPEISHLLNNPDIMRQTLEIARNPAMMQEMMRNQDLALSNLESIPGGYNALRRMYTDIQ 276
            ||||||||||||:||||||||||||:|||||||||||||||.|||||||||||||||||||||||
 Frog   198 QQLIQRNPEISHMLNNPDIMRQTLELARNPAMMQEMMRNQDRALSNLESIPGGYNALRRMYTDIQ 262

Human   277 EPMLNAAQEQFGGNPFASVGSSSSSGEGTQPSRTENRDPLPNPWAPPPATQSSATTSTTTSTGSG 341
            ||||||||||||||||||:.|::|:. |.||||||||||||||||||.:|..|.:|.:||...|
 Frog   263 EPMLNAAQEQFGGNPFASLVSNASNA-GNQPSRTENRDPLPNPWAPPSSTAGSTSTGSTTGANS- 325

Human   342 SGNSSSNATGNTVAAANYVASIFSTPGMQSLLQQITENPQLIQNMLSAPYMRSMMQSLSQNPDLA 406
            :|:|::..|.:|:  .|..|.:|:|||||||:|||||||||:||||||||||||||||||||:||
 Frog   326 TGSSTTTTTSSTL--PNLGAGMFNTPGMQSLMQQITENPQLMQNMLSAPYMRSMMQSLSQNPELA 388

Human   407 AQMMLNSPLFTANPQLQEQMRPQLPAFLQQMQNPDTLSAMSNPRAMQALMQIQQGLQTLATEAPG 471
            ||:|.|:|||:.|||||||||.|||.||||||||:||||||||||||||:||||||||||||||.
 Frog   389 AQVMQNNPLFSGNPQLQEQMRQQLPFFLQQMQNPETLSAMSNPRAMQALLQIQQGLQTLATEAPS 453

Human   472 LIPSFTPGVGVGVLGTAIGPVGPVTPIGPIGPIVPFTPIGPIGPIGPTGPAAPPGSTGSGGPTGP 536
            |:|...|                                 |.|.:|  .|.:.|.|
 Frog   454 LMPRTNP---------------------------------PFGGLG--SPNSSPAS--------- 474

Human   537 TVSSAAPSETTSP---TSESGPNQQFIQQMVQALAGANAP-QLPNPEVRFQQQLEQLNAMGFLNR 597
             |.|:||:|.:||   .||.| :|||||||:|||:|||.. |.||||||||.|||||:|||||||
 Frog   475 -VPSSAPTENSSPLSGLSEPG-HQQFIQQMLQALSGANPQNQNPNPEVRFQPQLEQLSAMGFLNR 537

Human   598 EANLQALIATGGDINAAIERLLGSQPS 624
            |||||||||||||||||||||||||||
 Frog   538 EANLQALIATGGDINAAIERLLGSQPS 564

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
UBQLN2	NP_038472.2	UBQ	33..103	CDD:214563	63/70 (90%)
		hPLIC_N	33..103	CDD:176403	63/70 (90%)
		STI1	382..426	CDD:128966	37/44 (84%)
		12 X 3 AA tandem repeats of P-X-X	491..526		5/35 (14%)
		UBA_PLICs	581..620	CDD:270582	37/39 (95%)
ubqln1	NP_989221.1	hPLIC_N	19..89	CDD:176403	63/70 (90%)
		UBA_PLICs	521..560	CDD:270582	37/39 (95%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
eggNOG	1	0.900				E1_COG5272
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010				D145564at32523
OrthoFinder	1	1.000				FOG0000468
OrthoInspector	0	0.000	Not matched by this tool.
Phylome	1	0.910		0.667	Consistency score
RoundUp	0	0.000	Not matched by this tool.
TreeFam	1	0.960
	5	4.780