Protein Alignment UBQLN2 and ubqln4

DIOPT Version :10

• Sequence 1: NP_038472.2
• Gene: UBQLN2 / 29978
• HGNCID: 12509
• Length: 624
• Species: Homo sapiens
• Sequence 2: NP_998521.2
• Gene: ubqln4 / 334337
• ZFINID: ZDB-GENE-030131-6269
• Length: 599
• Species: Danio rerio
• Alignment Length: 647
• Identity: 390/647 - (60%)
• Similarity: 469/647 - (72%)
• Gaps: 71/647 - (10%)

Human     1 MAENGESSGPPRPSRGPAA---AQGSAAAPAEPKIIKVTVKTPKEKEEFAVPENSSVQQFKEAIS 62
            ||||..:.        ||.   .:.:|||.|  .||||||||||:|||.|:.|::||.||||.||
Zfish     1 MAENSGTD--------PAVETNTEENAAASA--TIIKVTVKTPKDKEEIAIAEDASVAQFKEEIS 55

Human    63 KRFKSQTDQLVLIFAGKILKDQDTLIQHGIHDGLTVHLVIKSQNRPQGQSTQPSNA--------- 118
            ||||::.||||||||||||||.|||.||||.||||||||||:..:..|..:..::|
Zfish    56 KRFKAKQDQLVLIFAGKILKDGDTLGQHGIKDGLTVHLVIKTAQKTSGAGSSQTSASSGPGPSQG 120

Human   119 --AGTNTTSAS----TPRSNSTPISTNSNPFG-LGSLGGLAGLSSLGLSSTNFSELQSQMQQQLM 176
              :||:|.|.:    ||: .|.|..|.|.|.. |...|.|:|||:||:.|.||.|||.|||:|||
Zfish   121 SPSGTDTPSPAGNLGTPQ-GSGPSPTPSQPANILAGFGDLSGLSNLGMGSANFMELQQQMQRQLM 184

Human   177 ASPEMMIQIMENPFVQSMLSNPDLMRQLIMANPQMQQLIQRNPEISHLLNNPDIMRQTLEIARNP 241
            ::|||:.||||||.||||:||||||||:||||||||||::|||||||:||||::||||:|:||||
Zfish   185 SNPEMLSQIMENPLVQSMMSNPDLMRQMIMANPQMQQLMERNPEISHMLNNPELMRQTMELARNP 249

Human   242 AMMQEMMRNQDLALSNLESIPGGYNALRRMYTDIQEPMLNAAQEQFGGNPFASVGSSSSSGEGTQ 306
            |||||||||||.||||||||||||||||||||||||||.:||:||||.|||:::|.:..: .|||
Zfish   250 AMMQEMMRNQDRALSNLESIPGGYNALRRMYTDIQEPMFSAAREQFGNNPFSALGGNGEN-PGTQ 313

Human   307 PSRTENRDPLPNPWAPP---PATQSSATTSTTTSTGSGSGNSSSNATGNTVAAANYVASIFSTPG 368
            |||||||:||||||.||   .:|.||.|.:||:||.|.:..|.||..|  ::::|....:|::||
Zfish   314 PSRTENREPLPNPWGPPDGTASTTSSGTPTTTSSTTSSTTPSVSNPLG--ISSSNLGNGMFNSPG 376

Human   369 MQSLLQQITENPQLIQNMLSAPYMRSMMQSLSQNPDLAAQMMLNSPLFTANPQLQEQMRPQLPAF 433
            ||||:|||:|||||:|||:||||||:|||||:||||:|:|:::|:|||..|||||||||.|||.|
Zfish   377 MQSLMQQISENPQLMQNMISAPYMRTMMQSLAQNPDVASQVLMNNPLFAGNPQLQEQMRQQLPVF 441

Human   434 LQQMQNPDTLSAMSNPRAMQALMQIQQGLQTLATEAPGLIPSFTPGVGVGVLGTAIGPVGPVTPI 498
            |||||||:.||.|:|||||:||||||:|||||.||||||:|...||...|  |..:|..|...|.
Zfish   442 LQQMQNPEALSVMTNPRAMRALMQIQEGLQTLQTEAPGLMPGLGPGGMPG--GIPVGMPGAPLPT 504

Human   499 GPIGPIVPFTPIGPIGPIGPTGPAAPPGSTGSGGPTGPTVSSAAPSETTSPTSESGP-NQQFIQQ 562
            |     |..||..|           ||...||               |.:||:.:.| .||.:||
Zfish   505 G-----VTVTPENP-----------PPSGQGS---------------TPTPTAGASPAQQQLMQQ 538

Human   563 MVQALAGANAPQLPNPEVRFQQQLEQLNAMGFLNREANLQALIATGGDINAAIERLLGSQPS 624
            |:|..||.:| ....||||||||||||:||||:|||||||||||||||||||||||||||||
Zfish   539 MLQMFAGGSA-STQTPEVRFQQQLEQLSAMGFINREANLQALIATGGDINAAIERLLGSQPS 599

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
UBQLN2	NP_038472.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..32		10/33 (30%)
		Ubl_PLICs	31..103	CDD:340506	56/71 (79%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	106..141		11/49 (22%)
		STI1	182..215	CDD:128966	27/32 (84%)
		STI1	208..253	CDD:450205	37/44 (84%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	287..349		35/64 (55%)
		STI1	382..426	CDD:128966	31/43 (72%)
		12 X 3 AA tandem repeats of P-X-X	491..526		8/34 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	512..556		9/44 (20%)
		UBA_PLICs	581..620	CDD:270582	36/38 (95%)
ubqln4	NP_998521.2	Ubl_PLICs	25..96	CDD:340506	56/70 (80%)
		rad23	26..311	CDD:273167	188/286 (66%)
		UBA_PLICs	556..595	CDD:270582	36/38 (95%)