Protein Alignment UBQLN2 and Ubqn

DIOPT Version :8

• Sequence 1: NP_038472.2
• Gene: UBQLN2 / 29978
• HGNCID: 12509
• Length: 624
• Species: Homo sapiens
• Sequence 2: NP_001285457.1
• Gene: Ubqn / 32977
• FlyBaseID: FBgn0031057
• Length: 547
• Species: Drosophila melanogaster
• Alignment Length: 618
• Identity: 285/619 (46%)
• Similarity: 390/619 (63%)
• Gaps: 98/619 (16%)

Human    20 AQGSAAAPAEPKIIKVTVKTPKEKEEFAVPENSSVQQFKEAISKRFKSQTDQLVLIFAGKILKDQ 84
            |:|.:      |.|.|.|||||:|:...|.|:|.::.||..::::|:::.:||||||||||:||.
  Fly     2 AEGGS------KRINVVVKTPKDKKTVEVDEDSGIKDFKILVAQKFEAEPEQLVLIFAGKIMKDT 60

Human    85 DTLIQHGIHDGLTVHLVIKSQNRPQGQSTQPSNAAGTNTTSASTPRSNSTPISTNSNPFGLGSLG 149
            |||..|.|.|.||||||||:   |...:.||:.                .|......||||...|
  Fly    61 DTLQMHNIKDNLTVHLVIKA---PTRNNEQPAR----------------QPADVRQTPFGLNQFG 106

Human   150 GLAGLSSLGLSSTNFSELQSQMQQQLMASPEMMIQIMENPFVQSMLSNPDLMRQLIMANPQMQQL 214
            ||||:.:||..|..|.:||::||.:|:.:.:|:..:|:||.||.|::|||.|||||.:||||..|
  Fly   107 GLAGMEALGAGSNTFMDLQARMQNELLNNGDMLRSLMDNPMVQQMMNNPDTMRQLITSNPQMHDL 171

Human   215 IQRNPEISHLLNNPDIMRQTLEIARNPAMMQEMMRNQDLALSNLESIPGGYNALRRMYTDIQEPM 279
            :||||||||:|||||::|||:|:||||:|:||:||:.|.|:|||||:||||:||:|:|.||||||
  Fly   172 MQRNPEISHMLNNPDLLRQTMELARNPSMLQELMRSHDRAMSNLESVPGGYSALQRIYRDIQEPM 236

Human   280 LNAAQEQFGGNPFASVGSSSSSGEGTQPSR-TENRDPLPNPWAPPPATQSSATTSTT-TSTGSGS 342
            :|||.|.||.||||.:.....||.|..|.: ||||:||||||       ..|.:.|. |..|||:
  Fly   237 MNAATESFGRNPFAGLVDGGGSGAGNNPQQGTENRNPLPNPW-------GGANSGTNGTVGGSGA 294

Human   343 GNSSSNATGNTVAAANYVASIFSTPGMQSLLQQITENPQLIQNMLSAPYMRSMMQSLSQNPDLAA 407
            ||.:.:...|         ::.:||.|:|||||:.:||.::||:|:|||.||||:|:||:||:||
  Fly   295 GNPTGDLPPN---------NVLNTPAMRSLLQQMADNPAMMQNLLNAPYTRSMMESMSQDPDMAA 350

Human   408 QMMLNSPLFTANPQLQEQMRPQLPAFLQQMQNPDTLSAMSNPRAMQALMQIQQGLQTLATEAPGL 472
            :::.:|||.:.||.||||:|..:|.|:.|||||:.::.::||.||.|::|||||::.|.:.||||
  Fly   351 RLLSSSPLMSNNPALQEQVRQMMPQFMAQMQNPEVMNMLTNPDAMNAILQIQQGMEQLRSAAPGL 415

Human   473 -----IPSFTPGVGVGVLGTAIGPVGPVTPIGPIGPIVPFTPIGPIGPIGPTGPAAPPGSTGSGG 532
                 ||...||.|.|                                   |.||:   ..||||
  Fly   416 VGTLGIPPPPPGAGTG-----------------------------------TNPAS---GDGSGG 442

Human   533 PTGPTVSSAAPSE-------TTSPTSESGPNQQ----FIQQMVQALAGANAPQLPNPEVRFQQQL 586
            .:|.:.::.:||.       |.:.....|||.|    |:.:|:..::. ||.....||||:|.||
  Fly   443 NSGASTNNVSPSSGLNAGTGTPNLAPGGGPNAQLFNDFMMRMLNGMSN-NADNTQPPEVRYQSQL 506

Human   587 EQLNAMGFLNREANLQALIATGGDINAAIERLL 619
            ||||||||:||:|||||||||.||||||:||||
  Fly   507 EQLNAMGFVNRDANLQALIATFGDINAAVERLL 539

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
UBQLN2	NP_038472.2	UBQ	33..103	CDD:214563	39/70 (56%)
		hPLIC_N	33..103	CDD:176403	39/70 (56%)
		STI1	382..426	CDD:128966	26/44 (59%)
		12 X 3 AA tandem repeats of P-X-X	491..526		3/35 (9%)
		UBA_PLICs	581..620	CDD:270582	33/40 (83%)
Ubqn	NP_001285457.1	UBQ	9..79	CDD:214563	39/70 (56%)
		hPLIC_N	9..79	CDD:176403	39/70 (56%)
		STI1	322..368	CDD:128966	27/46 (59%)
		UBA_PLICs	501..537	CDD:270582	30/36 (83%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
eggNOG	1	0.900				E1_COG5272
Hieranoid	1	1.000
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	538	1.000	Inparanoid score	I1180
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010
OrthoDB	1	1.010				D1553668at2759
OrthoFinder	1	1.000				FOG0000468
OrthoInspector	1	1.000				T610151
orthoMCL	1	0.900				OOG5_127163
Panther	1	1.100			O	PTHR10677
Phylome	1	0.910		0.909	Consistency score
RoundUp	0	0.000	Not matched by this tool.
TreeFam	1	0.960
User_Submission	0	0.000	Not matched by this tool.
	11	10.840