Protein Alignment UBQLN2 and ubql-1

DIOPT Version :8

• Sequence 1: NP_038472.2
• Gene: UBQLN2 / 29978
• HGNCID: 12509
• Length: 624
• Species: Homo sapiens
• Sequence 2: NP_740883.1
• Gene: ubql-1 / 172434
• WormBaseID: WBGene00008852
• Length: 502
• Species: Caenorhabditis elegans
• Alignment Length: 603
• Identity: 218/604 (36%)
• Similarity: 303/604 (50%)
• Gaps: 115/604 (19%)

Human    29 EPKIIKVTVKTPKEKEEFAVPENSSVQQFKEAISKRF-KSQTDQLVLIFAGKILKDQDTLIQHGI 92
            |..:|||.||:|..|.:..:..::||.:.|:.:.... .:..:|:.:|:.||||||::||.||.|
 Worm     4 ESALIKVHVKSPSNKYDVEIAADASVSELKDKVLVFVPTANKEQVCIIYTGKILKDEETLTQHKI 68

Human    93 HDGLTVHLVIKSQNRPQGQSTQPSNAAGTNTTSASTPRSNSTPIS----TNSNPF-GLGSLGGLA 152
            .||.||||||::|.||     .|:.||.|.|.| |.|.||.||.|    || ||| .:|.:|..|
 Worm    69 ADGHTVHLVIRNQARP-----TPAPAAATPTAS-SAPSSNPTPSSQPNPTN-NPFAAMGGMGSPA 126

Human   153 GLSSLGLSSTNFSELQSQMQQQLMASPEMMIQIMENPFVQSMLSNPDLMRQLIMANPQMQQLIQR 217
                                 .::.:|:.|..:|:||..|.:|.||:.||.:|.:|||.|.||:|
 Worm   127 ---------------------DILNNPDAMRSVMDNPITQQLLGNPEFMRTIIQSNPQFQALIER 170

Human   218 NPEISHLLNNPDIMRQTLEIARNPAMMQEMMRNQDLALSNLESIPGGYNALRRMYTDIQEPMLNA 282
            |||:.|:||:|::||||:|:.|||.|.||||||.|.|:.||:.||||..||.|:|.|:|||:||:
 Worm   171 NPEVGHILNDPNVMRQTMEMIRNPNMFQEMMRNHDQAIRNLQGIPGGEAALERLYNDVQEPLLNS 235

Human   283 AQEQFGGNPFASVGSSSSSGEGTQPSRTENRDPLPNPWAPPPATQSSATTSTTTSTGSGSGNSSS 347
            |.....||||||:....||......:..||.:.||||||                  |.:..:::
 Worm   236 ATNSLSGNPFASLRGDQSSEPRVDRAGQENNEALPNPWA------------------SNANQATN 282

Human   348 NATGNTVAAANYVASIFSTPGMQSLLQQITENPQLIQNMLSAPYMRSMMQSLSQNPDLAAQMMLN 412
            |.:.|..|..|   |:..:||:.||::|:..||.:..:|.|...:.|:.|::|.||.|...::..
 Worm   283 NQSNNRSADFN---SLLDSPGISSLMEQMMSNPSMQASMFSPEVINSIRQNMSNNPGLIDSIVGQ 344

Human   413 SPLFTANPQLQEQMRPQLPAFLQQMQNPDTLSAMSNPRAMQALMQIQQGLQTLATEAPGLIPSFT 477
            .|....|||:.|.:|...|..|..|.:|..:.||.|||..:|..|||:|..||..|||.|:..|.
 Worm   345 IPSARDNPQISEGIRRSFPQMLNMMSDPSVMEAMRNPRVSEAFRQIQEGFSTLRREAPQLLNLFQ 409

Human   478 PGVGVGVLGTAIGPVGPVTPIGPIGPIVPFTPIGPIGPIGPTGPAAPPGSTGSGGP----TGPTV 538
            .|...|                              |..|....|:..|:..:.|.    ....:
 Worm   410 AGAMGG------------------------------GAFGSDANASSAGANSANGLADLFNSMNM 444

Human   539 SSAAPSETTSPTSESGPNQQFIQQMVQALAGANAPQLPNPEVRFQQQLEQLNAMGFLNREANLQA 603
            ....||.|.:|.                          |||..:..|||||.:|||.:|..|:.|
 Worm   445 GGGRPSSTAAPV--------------------------NPEQTYASQLEQLQSMGFSDRARNVAA 483

Human   604 LIATGGDINAAIERLLGS 621
            |.||.||:|||:||||.|
 Worm   484 LTATFGDLNAAVERLLNS 501

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
UBQLN2	NP_038472.2	UBQ	33..103	CDD:214563	31/71 (44%)
		hPLIC_N	33..103	CDD:176403	31/71 (44%)
		STI1	382..426	CDD:128966	13/44 (30%)
		12 X 3 AA tandem repeats of P-X-X	491..526		3/35 (9%)
		UBA_PLICs	581..620	CDD:270582	23/39 (59%)
ubql-1	NP_740883.1	hPLIC_N	8..79	CDD:176403	31/71 (44%)
		UBQ	18..>372	CDD:333228	155/403 (38%)
		UBA_PLICs	461..500	CDD:270582	23/39 (59%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
eggNOG	1	0.900				E1_COG5272
Hieranoid	1	1.000
Homologene	1	1.000				H81830
Inparanoid	1	1.050	366	1.000	Inparanoid score	I1377
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010
OrthoDB	1	1.010				D1553668at2759
OrthoFinder	1	1.000				FOG0000468
OrthoInspector	1	1.000				T390011
orthoMCL	1	0.900				OOG5_127163
Panther	1	1.100			O	PTHR10677
Phylome	1	0.910		0.909	Consistency score
RoundUp	0	0.000	Not matched by this tool.
TreeFam	1	0.960
	12	11.840