DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CYP2S1 and Cyp303a1

DIOPT Version :9

Sequence 1:	NP_085125.1	Gene:	CYP2S1 / 29785	HGNCID:	15654	Length:	504	Species:	Homo sapiens
Sequence 2:	NP_001285977.1	Gene:	Cyp303a1 / 49165	FlyBaseID:	FBgn0001992	Length:	503	Species:	Drosophila melanogaster

Alignment Length:	492	Identity:	133/492 - (27%)
Similarity:	228/492 - (46%)	Gaps:	44/492 - (8%)

- Green bases have known domain annotations that are detailed below.

Human    18 LLTLALSGTRARGHLPPGPTPLPLLGNLLQL-----RPGALYSGLMRLSKKYGPVFTIY---LGP 74
            ||.:...|.|.....||||...|::|:.||:     |.|.....:...:::|...:..|   :|.
  Fly    13 LLAILFGGVRKPKRFPPGPAWYPIVGSALQVSQLRCRLGMFCKVIDVFARQYVNPYGFYGLKIGK 77

Human    75 WRPVVVLVGQEAVREALGGQAEEFSGR--GTVAMLEGTFDGH-GVFFSNGERWRQLRKFTMLALR 136
            .: ||:....:|:.|.:..  |:..||  |....|. ||:.. ||..::||.|.:.|:|.:..|:
  Fly    78 DK-VVIAYTNDAISEMMTN--EDIDGRPDGIFYRLR-TFNSRLGVLLTDGEMWVEQRRFILRHLK 138

Human   137 DLGMGKREGEELIQAEARCLVETFQ------GTEGRPFDPSLLLAQATSNVVCSLLFGLRFSYED 195
            :.|..:....:::..||.||::..:      |.:....:...|.:....|.:..:|.|.|:....
  Fly   139 NFGFARSGMMDIVHNEATCLLQDLKDKVLKSGGKQTRIEMHDLTSVYVLNTLWCMLSGRRYEPGS 203

Human   196 KEFQAVVRAAGGTLLGVSSQGGQTYEMFSW-----FLRPLPGPHKQLLHHVSTLAAFTVRQVQQH 255
            .|...::.........:...|.    :||.     |:.|....:...:....:|..|..::::.|
  Fly   204 PEITQLLETFFELFKNIDMVGA----LFSHFPLLRFIAPNFSGYNGFVESHRSLYTFMSKEIELH 264

Human   256 QGNLDASGPARDLVDAFLLKMAQEEQNPGT-EFTNKNMLMTVIYLLFAGTMTVSTTVGYTLLLLM 319
            :.........|||:|::|  .||:|.|... .|:::::|...:.:..||:.|.:.::|:..:.|:
  Fly   265 RLTYKNYDEPRDLMDSYL--RAQDEGNDEKGMFSDQSLLAICLDMFLAGSETTNKSLGFCFMHLV 327

Human   320 KYPHVQKWVREELNRELGAGQAPSLG-DRTRLPYTDAVLHEAQRLLALVPMGIPRTLMRTTRFRG 383
            ..|.:|:...:|:...:|..:.|... |||:|||.:|:..||.|:..|...|||...:..||..|
  Fly   328 LQPEIQERAFQEIKEVVGLERIPEWSRDRTKLPYCEAITLEAVRMFMLHTFGIPHRAVCDTRLSG 392

Human   384 YTLPQGTEVFPLLGSILHDPNIFKHPEEFNPDRFLDADGRFRKHEAFLPFSLGKRVCLGEGLAKA 448
            |.:|:.|.|......:|.:|..|..||.|||||:| .||..:..|||.||..|:..|:|:.|.:.
  Fly   393 YEIPKDTMVIACFRGMLINPVDFPDPESFNPDRYL-FDGHLKLPEAFNPFGFGRHRCMGDLLGRQ 456

Human   449 ELFLFFTTILQAFSL---------ESPCPPDTLSLKP 476
            .||:|.||:||.|.:         |.|....|.::||
  Fly   457 NLFMFTTTVLQNFKMVAIPGQVPEEVPLEGATAAVKP 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CYP2S1	NP_085125.1	p450	49..488	CDD:365848	121/456 (27%)
Cyp303a1	NP_001285977.1	p450	28..480	CDD:278495	124/462 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920