Protein Alignment CYP2S1 and Cyp303a1

DIOPT Version :9

• Sequence 1: NP_085125.1
• Gene: CYP2S1 / 29785
• HGNCID: 15654
• Length: 504
• Species: Homo sapiens
• Sequence 2: NP_652070.1
• Gene: Cyp303a1 / 49165
• FlyBaseID: FBgn0001992
• Length: 503
• Species: Drosophila melanogaster
• Alignment Length: 492
• Identity: 133/492 - (27%)
• Similarity: 228/492 - (46%)
• Gaps: 44/492 - (8%)

Human    18 LLTLALSGTRARGHLPPGPTPLPLLGNLLQL-----RPGALYSGLMRLSKKYGPVFTIY---LGP 74
            ||.:...|.|.....||||...|::|:.||:     |.|.....:...:::|...:..|   :|.
  Fly    13 LLAILFGGVRKPKRFPPGPAWYPIVGSALQVSQLRCRLGMFCKVIDVFARQYVNPYGFYGLKIGK 77

Human    75 WRPVVVLVGQEAVREALGGQAEEFSGR--GTVAMLEGTFDGH-GVFFSNGERWRQLRKFTMLALR 136
            .: ||:....:|:.|.:..  |:..||  |....|. ||:.. ||..::||.|.:.|:|.:..|:
  Fly    78 DK-VVIAYTNDAISEMMTN--EDIDGRPDGIFYRLR-TFNSRLGVLLTDGEMWVEQRRFILRHLK 138

Human   137 DLGMGKREGEELIQAEARCLVETFQ------GTEGRPFDPSLLLAQATSNVVCSLLFGLRFSYED 195
            :.|..:....:::..||.||::..:      |.:....:...|.:....|.:..:|.|.|:....
  Fly   139 NFGFARSGMMDIVHNEATCLLQDLKDKVLKSGGKQTRIEMHDLTSVYVLNTLWCMLSGRRYEPGS 203

Human   196 KEFQAVVRAAGGTLLGVSSQGGQTYEMFSW-----FLRPLPGPHKQLLHHVSTLAAFTVRQVQQH 255
            .|...::.........:...|.    :||.     |:.|....:...:....:|..|..::::.|
  Fly   204 PEITQLLETFFELFKNIDMVGA----LFSHFPLLRFIAPNFSGYNGFVESHRSLYTFMSKEIELH 264

Human   256 QGNLDASGPARDLVDAFLLKMAQEEQNPGT-EFTNKNMLMTVIYLLFAGTMTVSTTVGYTLLLLM 319
            :.........|||:|::|  .||:|.|... .|:::::|...:.:..||:.|.:.::|:..:.|:
  Fly   265 RLTYKNYDEPRDLMDSYL--RAQDEGNDEKGMFSDQSLLAICLDMFLAGSETTNKSLGFCFMHLV 327

Human   320 KYPHVQKWVREELNRELGAGQAPSLG-DRTRLPYTDAVLHEAQRLLALVPMGIPRTLMRTTRFRG 383
            ..|.:|:...:|:...:|..:.|... |||:|||.:|:..||.|:..|...|||...:..||..|
  Fly   328 LQPEIQERAFQEIKEVVGLERIPEWSRDRTKLPYCEAITLEAVRMFMLHTFGIPHRAVCDTRLSG 392

Human   384 YTLPQGTEVFPLLGSILHDPNIFKHPEEFNPDRFLDADGRFRKHEAFLPFSLGKRVCLGEGLAKA 448
            |.:|:.|.|......:|.:|..|..||.|||||:| .||..:..|||.||..|:..|:|:.|.:.
  Fly   393 YEIPKDTMVIACFRGMLINPVDFPDPESFNPDRYL-FDGHLKLPEAFNPFGFGRHRCMGDLLGRQ 456

Human   449 ELFLFFTTILQAFSL---------ESPCPPDTLSLKP 476
            .||:|.||:||.|.:         |.|....|.::||
  Fly   457 NLFMFTTTVLQNFKMVAIPGQVPEEVPLEGATAAVKP 493

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CYP2S1	NP_085125.1	CYP2	64..490	CDD:410652	119/441 (27%)
Cyp303a1	NP_652070.1	CYP15A1-like	68..496	CDD:410744	118/437 (27%)