DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp2c7 and Cyp303a1

DIOPT Version :9

Sequence 1:	NP_058854.1	Gene:	Cyp2c7 / 29298	RGDID:	620379	Length:	490	Species:	Rattus norvegicus
Sequence 2:	NP_001285977.1	Gene:	Cyp303a1 / 49165	FlyBaseID:	FBgn0001992	Length:	503	Species:	Drosophila melanogaster

Alignment Length:	518	Identity:	134/518 - (25%)
Similarity:	241/518 - (46%)	Gaps:	56/518 - (10%)

- Green bases have known domain annotations that are detailed below.

  Rat     6 FLVLTLSSLILLSLWRQSSRR-RKLPPGPTPLPIIGNFLQID---------VKNISQSLTKFSKT 60
            :.|:.:....||::.....|: ::.||||...||:|:.||:.         .|.|.....::...
  Fly     3 YTVIWIFCATLLAILFGGVRKPKRFPPGPAWYPIVGSALQVSQLRCRLGMFCKVIDVFARQYVNP 67

  Rat    61 YGPVFTLYLGSQPTVILHGYEAIKEALIDNGEKFSGR--GSYPMNENVTKGFGIVFSNGNRWKEM 123
            || .:.|.:|....||.:..:||.|.:  ..|...||  |.:..........|::.::|..|.|.
  Fly    68 YG-FYGLKIGKDKVVIAYTNDAISEMM--TNEDIDGRPDGIFYRLRTFNSRLGVLLTDGEMWVEQ 129

  Rat   124 RRFTIMNFRNLGIGKRNIEDRVQEEAQCLVEELR----KTKGSPCDPSL-------ILNCAPCNV 177
            |||.:.:.:|.|..:..:.|.|..||.||:::|:    |:.|......:       :||...|
  Fly   130 RRFILRHLKNFGFARSGMMDIVHNEATCLLQDLKDKVLKSGGKQTRIEMHDLTSVYVLNTLWC-- 192

  Rat   178 ICSITFQNHFDYKDKEMLTFMEKVNENLKIMSSPWMQVCNSFPSLIDYFP---------GTHHKI 233
               :.....::....|:...:|...|..|.:        :...:|..:||         ..::..
  Fly   193 ---MLSGRRYEPGSPEITQLLETFFELFKNI--------DMVGALFSHFPLLRFIAPNFSGYNGF 246

  Rat   234 AKNINYMKSYLLKKIEEHQESL-DVTNPRDFVDYYLIKQKQANNIEQSEYSHENLTCSIMDLIGA 297
            .::...:.:::.|:||.|:.:. :...|||.:|.||..|.:.|: |:..:|.::|....:|:..|
  Fly   247 VESHRSLYTFMSKEIELHRLTYKNYDEPRDLMDSYLRAQDEGND-EKGMFSDQSLLAICLDMFLA 310

  Rat   298 GTETMSTTLRYALLLLMKYPHVTAKVQEEIDRVIGRHRSP-CMQDRKHMPYTDAMIHEVQRFINF 361
            |:||.:.:|.:..:.|:..|.:..:..:||..|:|..|.| ..:||..:||.:|:..|..|....
  Fly   311 GSETTNKSLGFCFMHLVLQPEIQERAFQEIKEVVGLERIPEWSRDRTKLPYCEAITLEAVRMFML 375

  Rat   362 VPTNLPHAVTCDIKFRNYLIPKGTKVLTSLTSVLHDSKEFPNPEMFDPGHFLDENGNFKKSDYFL 426
            ....:||...||.:...|.|||.|.|:.....:|.:..:||:||.|:|..:|.: |:.|..:.|.
  Fly   376 HTFGIPHRAVCDTRLSGYEIPKDTMVIACFRGMLINPVDFPDPESFNPDRYLFD-GHLKLPEAFN 439

  Rat   427 PFSAGKRACVGEGLARMQLFLFLTTILQNFNLKSLVHPKDI-DTMPVLNGFASLPPTYQLCFI 488
            ||..|:..|:|:.|.|..||:|.||:||||.:.::  |..: :.:|:....|::.| |.:..:
  Fly   440 PFGFGRHRCMGDLLGRQNLFMFTTTVLQNFKMVAI--PGQVPEEVPLEGATAAVKP-YDIMLV 499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp2c7	NP_058854.1	p450	30..487	CDD:278495	130/490 (27%)
Cyp303a1	NP_001285977.1	p450	28..480	CDD:278495	126/471 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.920