DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Atp8b1 and CG33298

DIOPT Version :9

Sequence 1:	NP_001099610.1	Gene:	Atp8b1 / 291555	RGDID:	1308488	Length:	1259	Species:	Rattus norvegicus
Sequence 2:	NP_995666.1	Gene:	CG33298 / 2768929	FlyBaseID:	FBgn0032120	Length:	1517	Species:	Drosophila melanogaster

Alignment Length:	1356	Identity:	419/1356 - (30%)
Similarity:	648/1356 - (47%)	Gaps:	317/1356 - (23%)

- Green bases have known domain annotations that are detailed below.

  Rat    91 KYASNAIKTYKYNALTFLPMNLFEQFKRAANFYFLILLILQAIPQISTLAWYTTLVPLLLVLGIT 155
            ::..|.|:|.||..|:|:|.||.|||.|.||.||:.:::|..:|:||.......::|:|.|||:|
  Fly   249 QFVGNKIRTTKYTLLSFIPKNLLEQFHRVANLYFIFIVLLNWVPEISAFGKEVAMIPVLFVLGVT 313

  Rat   156 AIKDLVDDVARHKMDKEINNRTCEVIKDG---RFKIIKWKDIQVGDVIRLKKNDFIPADILLLSS 217
            |:|||.:|..|...||.|||.||.|. ||   |:|.:||::::|||::.|..|:.:|||||||.:
  Fly   314 AVKDLFEDRRRRASDKRINNTTCRVY-DGETERYKKVKWQELRVGDIVHLSNNETVPADILLLRT 377

  Rat   218 SEPNSLCYVETAELDGETNLKFKMALEITDQYLQIEDNL--ATFDGFIECEEPNNRLDKFTGTLF 280
            |:|..:||::|.:||||||||.:   |:...:.:::...  :.|...:|.:.|..:|.:|.|.|.
  Fly   378 SDPQGVCYIDTCDLDGETNLKRR---EVVRGFEEMQSIFVPSKFVSRVEADAPTTKLYRFHGALI 439

  Rat   281 W-RNQSFPLDADKILLRGCVIRNTDVCHGLVIFAGADTKIMKNSGKTRFKRTKIDYLMNY-MVYT 343
            . ..:..|:..:.:|||...::|||...|:|::||.:||.|.|:...|:||::::..||. :::.
  Fly   440 HPTGERVPISTECLLLRESRLKNTDYIEGIVVYAGHETKSMLNNSGPRYKRSQVEQQMNIDVIWC 504

  Rat   344 IIIVLILVSAGLAIGHAYWEAQIGNYSWYLYDGENATPSYRGFLNFWGYIIVLNTMVPISLYVSV 408
            :||:|||...| |||...|.:...::..........|.:......||.||::|..|:|:||||::
  Fly   505 VIILLILCVVG-AIGCRMWLSSFTHFPVPYLPPNKLTANMESMWIFWTYIVILQVMIPLSLYVTI 568

  Rat   409 EVIRLGQSHFINWDLQMYYAEKDTPAKSRTTTLNEQLGQIHYIFSDKTGTLTQNIMTFKKCCING 473
            |:.::.|...|:.::.::.||.:...:.|...:.|:||||.:||:|||||||:|.|.|::|.:||
  Fly   569 ELCKILQVFHIHNNVDLFDAETNKQTECRAMNITEELGQIQHIFTDKTGTLTENKMIFRRCVVNG 633

  Rat   474 TIYGDHRDASQHSHSKIELVDFSW----------NEFADGKLAFYDH--YLIEQIQSGKEPEVRQ 526
            :.|       .|..|::|.: :|.          |:..:..:|....  ||....|     .:::
  Fly   634 SDY-------NHPPSELEKI-YSKPGAPAPPLIPNDNLNSDMAQLTQGTYLTPHAQ-----RIQE 685

  Rat   527 FFFLLSICHTVMV---------------------------------------------------- 539
            |..:|:||:||:|
  Fly   686 FLVVLAICNTVIVGAAPHRDMMNASGIIEVQQIGNSPANLKHGKQRQKLLASSTSTTTTTTIING 750

  Rat   540 ------------DR--------------------------------------------------- 541
                        ||
  Fly   751 PTTQPQVVSIPADRYIRLAESRSVTPSPPPNLLFALPAQSHQPTLSPISSSAESSPNSESESPSP 815

  Rat   542 ------------------------------------------------------IDGQINYQAAS 552
                                                                  .||:..|:|.|
  Fly   816 PMKNKSLSNSISPTGRAKAVINSKITSIATFLNAKTQGKRMKLPSSKTGTIYRTADGRPLYEAES 880

  Rat   553 PDEGALVNAARNFGFAFLARTQNTITVS--ELGTERTYSVLAILDFNSDRKRMSIIVRTPEGS-- 613
            |||.||||||.::....|.|:.|.|.||  ..|..|.|.:|.:|.|:|.||.|||:|| ..||
  Fly   881 PDELALVNAAYSYDCCLLNRSPNQILVSMPMAGATREYEILKVLPFDSSRKCMSIVVR-QIGSQE 944

  Rat   614 IRLYCKGADTVIYERL----HRMNP---MKQETQDALDIFASETLRTLCLCYKEIEEKEFAEWNK 671
            |.||.||||:.|...|    |. :|   ::::||..||.:|.|.||.|.:..:.:...::.:|..
  Fly   945 IVLYTKGADSSIMPVLVPCSHN-SPEGILREQTQQLLDRYAREGLRILVMAKRTLNSADYTDWWA 1008

  Rat   672 KFMAASVASSNRDEALDKVYEEIERDLILLGATAIEDKLQDGVPETISKLAKADIKIWVLTGDKK 736
            :.....::..||:..|...:.::|.:|.|||||.|||:|||||||||:.|..|.|.:|||||||.
  Fly  1009 RHQEIEMSLENRERRLRDSFAKLESNLTLLGATGIEDRLQDGVPETIASLLSAGISVWVLTGDKP 1073

  Rat   737 ETAENIGFACELLTEDTTI----CYGED-----INSLLHTRMENQRNRG----GVSAKFAPPAYE 788
            |||.||.::.:|.|:...:    ....|     ||..| |.|||.:...    |.|.:
  Fly  1074 ETAINIAYSAKLFTQQMELIRLTARSRDAAETAINFYL-TDMENDKTTSTLGYGQSLR------- 1130

  Rat   789 PFFPPGENRALIITGSWLNEILLEKKTKRSKILKLKFPRTEEERRMRSQSRRRLEEKKEQRQKNF 853
                 .:.|||::.|..|..||..|.       ||..|                          |
  Fly  1131 -----KKQRALVVDGKTLTFILDPKS-------KLILP--------------------------F 1157

  Rat   854 VDLACECSAVICCRVTPKQKAMVVDLVKRYKKAITLAIGDGANDVNMIKTAHIGVGISGQEGMQA 918
            :.|:..|::|:|||.||.|||.:|.:||......|||||||||||:||:.|.:||||||||||||
  Fly  1158 LRLSKRCASVLCCRSTPLQKAYLVKVVKEELNLRTLAIGDGANDVSMIQMADVGVGISGQEGMQA 1222

  Rat   919 VMSSDYSFAQFRYLQRLLLVHGRWSYIRMCKFLRYFFYKNFAFTLVHFWYSFFNGYSAQTAYEDW 983
            ||::|::..:||||:||||.||.|.|.|:.:.:.||||||.||..:.|||..:.|:|.|...:..
  Fly  1223 VMAADFTLPRFRYLERLLLAHGYWCYDRLSRMILYFFYKNAAFVFLIFWYQLYCGFSGQVMMDQM 1287

  Rat   984 FITLYNVLYSSLPVLLMGLLDQDVSDKLSLRFPGLYVVGQRDLLFNYKKFFVSLLHGVLTSMVLF 1048
            ::.|||::::|||.|.:|:.|:.|::.|.|:.|.||..|:..:.:....|::.||..:..|:|:|
  Fly  1288 YLMLYNLIFTSLPPLAIGVYDKRVAEDLLLKNPYLYKNGRLGVAYRPHDFWLILLDALYQSLVIF 1352

  Rat  1049 FIPFGAYLQTVGQDGEAPSDYQSFAVTMASALVITVNFQIGLDTSYWTFVNAFSIFGSIALY--F 1111
            |:...||       .|:......|..|:.::.:........::...||.::..||..|:..:  |
  Fly  1353 FVALCAY-------AESDVGIWEFGTTITASCLFANLVHCAIEIRSWTVLHVLSIVLSLGSFYLF 1410

  Rat  1112 GIMFD---FHSAGIHVLFPSAFQFTGWCFSDSESTASNALRQPYIWLTIILTVAVCLLPVVAIRF 1173
            .|::|   .:..|:.    |::.....||:.:..           ||.|:|:..|.:||.:.:..
  Fly  1411 AIVYDSVCMNCFGVR----SSYWVIFVCFASAVH-----------WLVIMLSTVVAVLPRLLLTT 1460

  Rat  1174 LSMTIWPSESDKI--QKHRKRLKAEE---QWKRRQSVFRRGASS--RRSAYAFSHQ 1222
            :.:::.|.:|.|:  |..|:|.:.|.   .|.|..|     |||  |.:.|...:|
  Fly  1461 VRISLCPDDSTKVILQSKRERSRGEALLVTWSRSTS-----ASSIYRITDYGSKNQ 1511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atp8b1	NP_001099610.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..52
		PhoLip_ATPase_N	86..142	CDD:292826	22/50 (44%)
		ATPase-Plipid	92..1187	CDD:273734	406/1313 (31%)
		E1-E2_ATPase	171..>234	CDD:278548	32/65 (49%)
		Cation_ATPase	534..628	CDD:289987	50/266 (19%)
		HAD_like	<875..919	CDD:304363	28/43 (65%)
		PhoLip_ATPase_C	919..1181	CDD:292829	77/266 (29%)
CG33298	NP_995666.1	PhoLip_ATPase_N	249..299	CDD:292826	22/49 (45%)
		ATPase-Plipid	250..1473	CDD:273734	405/1310 (31%)
		E1-E2_ATPase	302..>394	CDD:278548	45/92 (49%)
		Cation_ATPase	<880..965	CDD:289987	41/85 (48%)
		HAD_like	<1177..1240	CDD:304363	39/62 (63%)
		PhoLip_ATPase_C	1223..1468	CDD:292829	77/266 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0206
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53737
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	1	1.000	-	-		FOG0000076
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.830