Protein Alignment Atp8b1 and CG33298

DIOPT Version :10

• Sequence 1: NP_001424194.1
• Gene: Atp8b1 / 291555
• RGDID: 1308488
• Length: 1251
• Species: Rattus norvegicus
• Sequence 2: NP_995666.1
• Gene: CG33298 / 2768929
• FlyBaseID: FBgn0032120
• Length: 1517
• Species: Drosophila melanogaster
• Alignment Length: 1355
• Identity: 421/1355 - (31%)
• Similarity: 645/1355 - (47%)
• Gaps: 323/1355 - (23%)

  Rat    91 KYASNAIKTYKYNALTFLPMNLFEQFKRAANFYFLILLILQAIPQISTLAWYTTLVPLLLVLGIT 155
            ::..|.|:|.||..|:|:|.||.|||.|.||.||:.:::|..:|:||.......::|:|.|||:|
  Fly   249 QFVGNKIRTTKYTLLSFIPKNLLEQFHRVANLYFIFIVLLNWVPEISAFGKEVAMIPVLFVLGVT 313

  Rat   156 AIKDLVDDVARHKMDKEINNRTCEVIKDG---RFKIIKWKDIQVGDVIRLKKNDFIPADILLLSS 217
            |:|||.:|..|...||.|||.||.|. ||   |:|.:||::::|||::.|..|:.:|||||||.:
  Fly   314 AVKDLFEDRRRRASDKRINNTTCRVY-DGETERYKKVKWQELRVGDIVHLSNNETVPADILLLRT 377

  Rat   218 SEPNSLCYVETAELDGETNLKFKMALEITDQYLQIEDNL--ATFDGFIECEEPNNRLDKFTGTLF 280
            |:|..:||::|.:||||||||.:   |:...:.:::...  :.|...:|.:.|..:|.:|.|.|.
  Fly   378 SDPQGVCYIDTCDLDGETNLKRR---EVVRGFEEMQSIFVPSKFVSRVEADAPTTKLYRFHGALI 439

  Rat   281 W-RNQSFPLDADKILLRGCVIRNTDVCHGLVIFAGADTKIMKNSGKTRFKRTKIDYLMNY-MVYT 343
            . ..:..|:..:.:|||...::|||...|:|::||.:||.|.|:...|:||::::..||. :::.
  Fly   440 HPTGERVPISTECLLLRESRLKNTDYIEGIVVYAGHETKSMLNNSGPRYKRSQVEQQMNIDVIWC 504

  Rat   344 IIIVLILVSAGLAIGHAYWEAQIGNYSWYLYDGENATPSYRGFLNFWGYIIVLNTMVPISLYVSV 408
            :||:|||...| |||...|.:...::..........|.:......||.||::|..|:|:||||::
  Fly   505 VIILLILCVVG-AIGCRMWLSSFTHFPVPYLPPNKLTANMESMWIFWTYIVILQVMIPLSLYVTI 568

  Rat   409 EVIRLGQSHFINWDLQMYYAEKDTPAKSRTTTLNEQLGQIHYIFSDKTGTLTQNIMTFKKCCING 473
            |:.::.|...|:.::.::.||.:...:.|...:.|:||||.:||:|||||||:|.|.|::|.:||
  Fly   569 ELCKILQVFHIHNNVDLFDAETNKQTECRAMNITEELGQIQHIFTDKTGTLTENKMIFRRCVVNG 633

  Rat   474 TIYGDHRDASQHSHSKIELVDFSW----------NEFADGKLAFYDH--YLIEQIQSGKEPEVRQ 526
            :.|       .|..|::|.: :|.          |:..:..:|....  ||....|     .:::
  Fly   634 SDY-------NHPPSELEKI-YSKPGAPAPPLIPNDNLNSDMAQLTQGTYLTPHAQ-----RIQE 685

  Rat   527 FFFLLSICHTVMV---------------------------------------------------- 539
            |..:|:||:||:|
  Fly   686 FLVVLAICNTVIVGAAPHRDMMNASGIIEVQQIGNSPANLKHGKQRQKLLASSTSTTTTTTIING 750

  Rat   540 ------------DR--------------------------------------------------- 541
                        ||
  Fly   751 PTTQPQVVSIPADRYIRLAESRSVTPSPPPNLLFALPAQSHQPTLSPISSSAESSPNSESESPSP 815

  Rat   542 ------------------------------------------------------IDGQINYQAAS 552
                                                                  .||:..|:|.|
  Fly   816 PMKNKSLSNSISPTGRAKAVINSKITSIATFLNAKTQGKRMKLPSSKTGTIYRTADGRPLYEAES 880

  Rat   553 PDEGALVNAARNFGFAFLARTQNTITVS--ELGTERTYSVLAILDFNSDRKRMSIIVRTPEGS-- 613
            |||.||||||.::....|.|:.|.|.||  ..|..|.|.:|.:|.|:|.||.|||:|| ..||
  Fly   881 PDELALVNAAYSYDCCLLNRSPNQILVSMPMAGATREYEILKVLPFDSSRKCMSIVVR-QIGSQE 944

  Rat   614 IRLYCKGADTVIYERL----HRMNP---MKQETQDALDIFASETLRTLCLCYKEIEEKEFAEWNK 671
            |.||.||||:.|...|    |. :|   ::::||..||.:|.|.||.|.:..:.:...::.:|..
  Fly   945 IVLYTKGADSSIMPVLVPCSHN-SPEGILREQTQQLLDRYAREGLRILVMAKRTLNSADYTDWWA 1008

  Rat   672 KFMAASVASSNRDEALDKVYEEIERDLILLGATAIEDKLQDGVPETISKLAKADIKIWVLTGDKK 736
            :.....::..||:..|...:.::|.:|.|||||.|||:|||||||||:.|..|.|.:|||||||.
  Fly  1009 RHQEIEMSLENRERRLRDSFAKLESNLTLLGATGIEDRLQDGVPETIASLLSAGISVWVLTGDKP 1073

  Rat   737 ETAENIGFACELLTEDTTI----CYGED-----INSLLHTRMENQRNRG----GVSAKFAPPAYE 788
            |||.||.::.:|.|:...:    ....|     ||..| |.|||.:...    |.|.:
  Fly  1074 ETAINIAYSAKLFTQQMELIRLTARSRDAAETAINFYL-TDMENDKTTSTLGYGQSLR------- 1130

  Rat   789 PFFPPGENRALIITGSWLNEILLEKKTKRSKILKLKFPRTEEERRMRSQSRRRLEEKKEQRQKNF 853
                 .:.|||::.|..|..||..|.       ||..|                          |
  Fly  1131 -----KKQRALVVDGKTLTFILDPKS-------KLILP--------------------------F 1157

  Rat   854 VDLACECSAVICCRVTPKQKAMVVDLVKRYKKAITLAIGDGANDVNMIKTAHIGVGISGQEGMQA 918
            :.|:..|::|:|||.||.|||.:|.:||......|||||||||||:||:.|.:||||||||||||
  Fly  1158 LRLSKRCASVLCCRSTPLQKAYLVKVVKEELNLRTLAIGDGANDVSMIQMADVGVGISGQEGMQA 1222

  Rat   919 VMSSDYSFAQFRYLQRLLLVHGRWSYIRMCKFLRYFFYKNFAFTLVHFWYSFFNGYSAQTAYEDW 983
            ||::|::..:||||:||||.||.|.|.|:.:.:.||||||.||..:.|||..:.|:|.|...:..
  Fly  1223 VMAADFTLPRFRYLERLLLAHGYWCYDRLSRMILYFFYKNAAFVFLIFWYQLYCGFSGQVMMDQM 1287

  Rat   984 FITLYNVLYSSLPVLLMGLLDQDVSDKLSLRFPGLYVVGQRDLLFNYKKFFVSLLHGVLTSMVLF 1048
            ::.|||::::|||.|.:|:.|:.|::.|.|:.|.||..|:..:.:....|::.||..:..|:|:|
  Fly  1288 YLMLYNLIFTSLPPLAIGVYDKRVAEDLLLKNPYLYKNGRLGVAYRPHDFWLILLDALYQSLVIF 1352

  Rat  1049 FIPFGAYLQTVGQDGEAPSDYQSFAVTMASALVITVNFQIGLDTSYWTFVNAFSIFGSIALY--F 1111
            |:...||       .|:......|..|:.::.:........::...||.::..||..|:..:  |
  Fly  1353 FVALCAY-------AESDVGIWEFGTTITASCLFANLVHCAIEIRSWTVLHVLSIVLSLGSFYLF 1410

  Rat  1112 GIMFD---FHSAG-------IHVLFPSAFQFTGTASNALRQPYIWLTIILTVAVCLLPVVAIRFL 1166
            .|::|   .:..|       |.|.|.||..              ||.|:|:..|.:||.:.:..:
  Fly  1411 AIVYDSVCMNCFGVRSSYWVIFVCFASAVH--------------WLVIMLSTVVAVLPRLLLTTV 1461

  Rat  1167 SMTIWPSESDKI--QKHRKRLKAEE---QWKRRQSVFRRGASS--RRSAYAFSHQ 1214
            .:::.|.:|.|:  |..|:|.:.|.   .|.|..|     |||  |.:.|...:|
  Fly  1462 RISLCPDDSTKVILQSKRERSRGEALLVTWSRSTS-----ASSIYRITDYGSKNQ 1511

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Atp8b1	NP_001424194.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..52
CG33298	NP_995666.1	P-type_ATPase_APLT_Dnf-like	252..1355	CDD:319770	379/1168 (32%)