Protein Alignment ATP11C and CG33298

DIOPT Version :10

• Sequence 1: XP_047297972.1
• Gene: ATP11C / 286410
• HGNCID: 13554
• Length: 1153
• Species: Homo sapiens
• Sequence 2: NP_995666.1
• Gene: CG33298 / 2768929
• FlyBaseID: FBgn0032120
• Length: 1517
• Species: Drosophila melanogaster
• Alignment Length: 1375
• Identity: 403/1375 - (29%)
• Similarity: 620/1375 - (45%)
• Gaps: 317/1375 - (23%)

Human     5 PSHRSPPARLLELLTDPQIPEAVC---APSSQCAGEE--------------KRV----------- 41
            |.|:..|||      :|..|.:..   ..|.|.:..|              ||:
  Fly   164 PGHKEEPAR------EPSAPTSATGGRGHSRQASRSESIYTLRRTEAPPWWKRLTLCNYNTGDKF 222

Human    42 ---GTRTVFVGNH---PVSETEAYIAQRFCDNRIVSSKYTLWNFLPKNLFEQFRRIANFYFLIIF 100
               ..||| |.||   |.:....:...:|..|:|.::||||.:|:||||.|||.|:||.||:.|.
  Fly   223 EERSYRTV-VPNHTVPPKTPKRDHPNGQFVGNKIRTTKYTLLSFIPKNLLEQFHRVANLYFIFIV 286

Human   101 LVQ-VTVDTPTSPVTSGLPLFFVITVTAIKQGYEDCLRHRADNEVNKST--VYIIENAKRVRKES 162
            |:. |...:......:.:|:.||:.|||:|..:||..|..:|..:|.:|  ||..|..:..:.:.
  Fly   287 LLNWVPEISAFGKEVAMIPVLFVLGVTAVKDLFEDRRRRASDKRINNTTCRVYDGETERYKKVKW 351

Human   163 EKIKVGDVVEVQADETFPCDLILLSSCTTDGTCYVTTASLDGESNCKTHYAVRDTIALCTAESID 227
            ::::|||:|.:..:||.|.|::||.:....|.||:.|..||||:|.|....||....:.:.....
  Fly   352 QELRVGDIVHLSNNETVPADILLLRTSDPQGVCYIDTCDLDGETNLKRREVVRGFEEMQSIFVPS 416

Human   228 TLRAAIECEQPQPDLYKFVGRINIYSNSLEAVARSLGPENLLLKGATLKNTEKIYGVAVYTGMET 292
            ...:.:|.:.|...||:|.|.: |:... |.|  .:..|.|||:.:.||||:.|.|:.||.|.||
  Fly   417 KFVSRVEADAPTTKLYRFHGAL-IHPTG-ERV--PISTECLLLRESRLKNTDYIEGIVVYAGHET 477

Human   293 KMALNYQGKSQKRSAVEKSINAFLIVYLFILLTKAAVCTTLKYVWQST------PYNDEPWYNQK 351
            |..||..|...|||.||:.:|..:|..:.|||....|......:|.|:      ||...    .|
  Fly   478 KSMLNNSGPRYKRSQVEQQMNIDVIWCVIILLILCVVGAIGCRMWLSSFTHFPVPYLPP----NK 538

Human   352 TQKERETLKVLKMFTDFLSFMVLFNFIIPVSMYVTVEMQKFLGSFFISWDKDFYDEEINEGALVN 416
            .....|::.:      |.:::|:...:||:|:|||:|:.|.|..|.|..:.|.:|.|.|:.....
  Fly   539 LTANMESMWI------FWTYIVILQVMIPLSLYVTIELCKILQVFHIHNNVDLFDAETNKQTECR 597

Human   417 TSDLNEELGQVDYVFTDKTGTLTENSMEFIECCIDGHKYKGVTQEVDGLSQTDGT----LTYFDK 477
            ..::.|||||:.::|||||||||||.|.|..|.::|..|.....|::.:....|.    |...|.
  Fly   598 AMNITEELGQIQHIFTDKTGTLTENKMIFRRCVVNGSDYNHPPSELEKIYSKPGAPAPPLIPNDN 662

Human   478 VDKNREEL---------------FLRALCLCHTV-----------------EIK----------- 499
            ::.:..:|               ||..|.:|:||                 |::
  Fly   663 LNSDMAQLTQGTYLTPHAQRIQEFLVVLAICNTVIVGAAPHRDMMNASGIIEVQQIGNSPANLKH 727

Human   500 ----------------TNDAVDGAT-----------------ESAELT----------------- 514
                            |...::|.|                 ||..:|
  Fly   728 GKQRQKLLASSTSTTTTTTIINGPTTQPQVVSIPADRYIRLAESRSVTPSPPPNLLFALPAQSHQ 792

Human   515 ----------------------------------------------------------------- 514
                                                                             
  Fly   793 PTLSPISSSAESSPNSESESPSPPMKNKSLSNSISPTGRAKAVINSKITSIATFLNAKTQGKRMK 857

Human   515 ------------------YISSSPDEIALVKGAKRYGFTFLGNRNGYMRVENQ-------RKEIE 554
                              |.:.||||:|||..|..|....|.      |..||       .....
  Fly   858 LPSSKTGTIYRTADGRPLYEAESPDELALVNAAYSYDCCLLN------RSPNQILVSMPMAGATR 916

Human   555 EYELLHTLNFDAVRRRMSVIVKTQEG--DILLFCKGADSAVFPRVQ--NHEI------ELTKVHV 609
            |||:|..|.||:.|:.||::|: |.|  :|:|:.|||||::.|.:.  :|..      |.|:..:
  Fly   917 EYEILKVLPFDSSRKCMSIVVR-QIGSQEIVLYTKGADSSIMPVLVPCSHNSPEGILREQTQQLL 980

Human   610 ERNAMDGYRTLCVAFKEIAPDDYERINRQLIEAKMALQDREEKMEKVFDDIETNMNLIGATAVED 674
            :|.|.:|.|.|.:|.:.:...||.....:..|.:|:|::||.::...|..:|:|:.|:|||.:||
  Fly   981 DRYAREGLRILVMAKRTLNSADYTDWWARHQEIEMSLENRERRLRDSFAKLESNLTLLGATGIED 1045

Human   675 KLQDQAAETIEALHAAGLKVWVLTGDKMETAKSTCYACRLFQTNTELLELTTKTIEESERKEDRL 739
            :|||...|||.:|.:||:.||||||||.|||.:..|:.:||....||:.||.       |..|..
  Fly  1046 RLQDGVPETIASLLSAGISVWVLTGDKPETAINIAYSAKLFTQQMELIRLTA-------RSRDAA 1103

Human   740 HELLIEYRKKLLHEFPKSTRSFKKAWTEHQEYGLIIDGSTLSLILNSSQDSSSNNYKSI--FLQI 802
            ...:..|...:.::...||..:.::..:.|. .|::||.||:.||:...       |.|  ||::
  Fly  1104 ETAINFYLTDMENDKTTSTLGYGQSLRKKQR-ALVVDGKTLTFILDPKS-------KLILPFLRL 1160

Human   803 CMKCTAVLCCRMAPLQKAQIVRMVK---NLKGSPITLSIGDGANDVSMILESHVGIGIKGKEGRQ 864
            ..:|.:|||||..|||||.:|::||   ||:    ||:|||||||||||..:.||:||.|:||.|
  Fly  1161 SKRCASVLCCRSTPLQKAYLVKVVKEELNLR----TLAIGDGANDVSMIQMADVGVGISGQEGMQ 1221

Human   865 AARNSDYSVPKFKHLKKLLLAHGHLYYVRIAHLVQYFFYKNLCFILPQFLYQFFCGFSQQPLYDA 929
            |...:|:::|:|::|::||||||:..|.|::.::.||||||..|:...|.||.:||||.|.:.|.
  Fly  1222 AVMAADFTLPRFRYLERLLLAHGYWCYDRLSRMILYFFYKNAAFVFLIFWYQLYCGFSGQVMMDQ 1286

Human   930 AYLTMYNICFTSLPILAYSLLEQHINIDTLTSDPRLYMKISGNAMLQLGPFLYWTFL--AAFEGT 992
            .||.:||:.|||||.||..:.::.:..|.|..:|.||.  :|...:...|..:|..|  |.::..
  Fly  1287 MYLMLYNLIFTSLPPLAIGVYDKRVAEDLLLKNPYLYK--NGRLGVAYRPHDFWLILLDALYQSL 1349

Human   993 VFFFGTYFLFQTASLEENGKVYGNWTFGTIVFTVLVFTVTLKLALDTRFWTWINHFVIWGSLAFY 1057
            |.||.....:..:.:       |.|.|||.:....:|...:..|::.|.||.::...|..||..:
  Fly  1350 VIFFVALCAYAESDV-------GIWEFGTTITASCLFANLVHCAIEIRSWTVLHVLSIVLSLGSF 1407

Human  1058 VFFSFFWGGIIWPFLKQQRMYFVFAQMLSSVSTWLAIILLIFISLFPEILL-------------- 1108
            ..|:..:..:.......:..|:|.....:|...||.|:|...:::.|.:||
  Fly  1408 YLFAIVYDSVCMNCFGVRSSYWVIFVCFASAVHWLVIMLSTVVAVLPRLLLTTVRISLCPDDSTK 1472

Human  1109 IVLKNVRRRS 1118
            ::|::.|.||
  Fly  1473 VILQSKRERS 1482

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP11C	XP_047297972.1	P-type_ATPase_APLT_Dnf-like	66..998	CDD:319770	355/1144 (31%)
		PhoLip_ATPase_C	886..1113	CDD:465071	69/242 (29%)
CG33298	NP_995666.1	P-type_ATPase_APLT_Dnf-like	252..1355	CDD:319770	355/1144 (31%)