DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG43980 and Abtb2

DIOPT Version :9

Sequence 1:	NP_001262185.1	Gene:	CG43980 / 2768995	FlyBaseID:	FBgn0264711	Length:	1549	Species:	Drosophila melanogaster
Sequence 2:	NP_849221.2	Gene:	Abtb2 / 99382	MGIID:	2139365	Length:	1024	Species:	Mus musculus

Alignment Length:	1103	Identity:	396/1103 - (35%)
Similarity:	593/1103 - (53%)	Gaps:	187/1103 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   510 LEDIKL-----AMLTLRSQTSSSTYSSLSAGSESSEPARRL----------GRYSSLETVVTSTS 559
            |||:.|     |..:.||.:.||:.|:..|.:.|::..|..          .|::|.:||.|...
Mouse    12 LEDLTLDSGYGAGDSCRSLSLSSSKSNSQALNSSAQQHRGAAWWCYSGSMNSRHNSWDTVNTVLP 76

  Fly   560 ADEFVWVDSHN---RLVELQHPPWSQQCILKVLRNGRCQQQAEHLAVEAVSRLGYLLQRALVRIA 621
            .|..| .|..:   ||.||:..||::..:.:|||.....::....:.|||.||..||:|||:|:|
Mouse    77 EDPEV-ADLFSRCPRLPELEEFPWTEGDVARVLRKSVGGRRLPSFSAEAVRRLAGLLRRALIRVA 140

  Fly   622 REIQRFSAGVGLCSKQEVVGALRVVLSSSLADSCTKACLRSAAMFAVPGESALKQSKSARAGLQL 686
            ||.||.|.....|::.||..|:|:|.|.:||:||..|.:::.:::::.....|::.||||.||..
Mouse   141 REAQRLSVLHAKCTRFEVQSAVRLVHSWALAESCALAAVKALSLYSMSAGDGLRRGKSARCGLTF 205

  Fly   687 SVGRFYRWMTDARLGKFIHEYAAVYLCAGIENLLEEIALQC-------------NGTTAAALDQS 738
            |||||:|||.|.|:...||||||:.|.|.:|||:|||..:.             ...:|.||:..
Mouse   206 SVGRFFRWMVDTRISVRIHEYAAISLTACMENLVEEIRARVLASQSPDGGGAGGGEVSAEALEMV 270

  Fly   739 IASSGDVWGLLQPFAHLNAGRIASGALALPRWANSLDQVIASSGDFRGH---------------- 787
            |.:..::||:|||:.||..|:.|:|.|:||.:.:..      :|...||
Mouse   271 INNDAELWGVLQPYEHLICGKNANGVLSLPAYFSPY------NGGSLGHDERADAYAQLELRTLE 329

  Fly   788 ---LATCVGSIRELKEKALRTQQEFQLAAAL-------------------SGSALAALFYFMRCS 830
               ||||||||.||.:...|.....|....|                   |..||..|:||:||.
Mouse   330 QSLLATCVGSISELSDLVSRAMHHMQGRHPLCPGTSPARQARQPPQPITWSPDALHTLYYFLRCP 394

  Fly   831 QLEHTELLAASGCHAGQAQSAAPGGGTSSAGHHVQELCYERAYVVLPPLAEWLRVAAAHAEHRNA 895
            |:|..|           ..:..|...|         |..||.:::||||.||:|||..:||||.:
Mouse   395 QMESME-----------NPNLDPPRMT---------LNNERPFMLLPPLMEWMRVAITYAEHRRS 439

  Fly   896 MMIDKDDVMQAARLLLPGVDCPIRPVAH----------DEELPTKKTHFNTAPTVSSTGTGTGSS 950
            ..:|..|:.|||||||||:||..|.:..          |....|::  ||
Mouse   440 PTVDSGDIRQAARLLLPGLDCEPRQLKPECCFSSFRRLDARAATER--FN--------------- 487

  Fly   951 SCSSPVVSGIGIGIGEDTSELGRRATIGVAFKLLLTGRAELLAQAAQLLPPTTRYDTQNSAGLTA 1015
                              .:||        |::|..||.:|::||.:.|.| ...:|.:..|:|.
Mouse   488 ------------------QDLG--------FRMLNCGRTDLISQAIEALGP-DGVNTMDDQGMTP 525

  Fly  1016 LMIASIRNDEVALHALLDAGCDPNVEVPPAGSAGYPAIQPDTQHWTALSFAASRANYVALRILLE 1080
            ||.|....||..:..|:|||.:.:::| |:.|..:|::.||::|||:|:||....:...:::||:
Mouse   526 LMYACAAGDEAMVQMLIDAGANLDIQV-PSHSPRHPSVHPDSRHWTSLTFAVLHGHISVVQLLLD 589

  Fly  1081 RGGKVEGGA-RSSEEKCTLTPLQLAAGTGNLEIVALLLAHGANAFLSTQQKDSLCFAGSAQKGCF 1144
            .|..|||.| .|.|:....||||||:..||.|:|:|||:.||:..||..:.:.:..:...:..||
Mouse   590 AGAHVEGSAVNSGEDSYAETPLQLASAAGNYELVSLLLSRGADPLLSMLEANGMASSLHEEMNCF 654

  Fly  1145 CAISVAAAHGHRSCLRKLLTHPVSPGTRDVLSLEEMLAEG----DVGGVRGSGGPTGAGGPNSAS 1205
               |.:||||||:.||||||.| .....|||||||:||||    |......|.||.
Mouse   655 ---SHSAAHGHRNVLRKLLTQP-QQAKADVLSLEEILAEGVEESDTSSQGSSEGPV--------- 706

  Fly  1206 ASGNNEDILPLLNKTQIKRLQEAMYHSAENNHLDITIELRKLGVPWTLHCWMHALSAAHDLRLDA 1270
                      .|::|:.|.||||||:|||:.:||||:|||.|||||.||.|:.:|..:......:
Mouse   707 ----------RLSRTRTKALQEAMYYSAEHGYLDITMELRALGVPWKLHIWIESLRTSFSQSRYS 761

  Fly  1271 VIDQLLQDFLQVCPDDYSAQFVSECLPLLFNIFR-NKNEGTTLLLADIFATCFGWETLPPVKEQP 1334
            |:..||:||..:..::|:.:.|:|.|.|:|:|.: :||:.....||.||..|:|...:|.:   |
Mouse   762 VVQSLLKDFSSIKEEEYNEELVTEGLQLMFDILKTSKNDSVLQQLATIFTHCYGTSPIPSI---P 823

  Fly  1335 PMQPVQGSRIDPKFVNNPELSDVTFRVEGKIFYGHKIVLVTASPRFQSMLSSKL-SEGSSTPTVQ 1398
            .::....:|:||.|:||.|:|||||.||||:||.||::|||||.||::::::|. .:|.|:.|::
Mouse   824 EIRKTLPARLDPHFLNNKEMSDVTFLVEGKLFYAHKVLLVTASNRFKTLMTNKSEQDGDSSKTIE 888

  Fly  1399 INDIRYHIFQLVMQFLYCGGCSSLDVAHGDVLELMAAASFFQLEGLLRYTEARCSEMVDVDNVVA 1463
            |:||:|||||::||:||.||..|:::...|:|:|::||:.|||:.|.|:.|..||:.:.|::.|.
Mouse   889 ISDIKYHIFQMLMQYLYYGGTESMEIPTADILQLLSAANLFQLDALQRHCEILCSQTLSVESAVN 953

  Fly  1464 MYIHAKVYNANRLLEFCQCFLLQNMVALLTYDDSVKRLLFAK--KIPNHDVLAGLLQTLQNRL 1524
            .|.:||::||..|..||:.|.|::|.|||. .|:.::|::.:  |:...|.|..|..||..|:
Mouse   954 TYKYAKIHNAPELALFCEGFFLKHMKALLE-QDAFRQLIYGRSSKVQGLDPLQDLQSTLAERV 1015

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43980	NP_001262185.1	Med25_SD1	265..424	CDD:288132
		H2A	675..>728	CDD:305064	30/65 (46%)
		ANK	1006..1163	CDD:238125	62/157 (39%)
		ANK repeat	1012..1056	CDD:293786	15/43 (35%)
		Ank_2	1016..1122	CDD:289560	44/106 (42%)
		ANK repeat	1058..1091	CDD:293786	13/33 (39%)
		ANK repeat	1093..1121	CDD:293786	14/27 (52%)
		ANK repeat	1141..1173	CDD:293786	16/31 (52%)
		BTB	1350..1446	CDD:279045	51/96 (53%)
		BTB	1356..1449	CDD:197585	48/93 (52%)
		SPOP_C_like	1456..>1492	CDD:269810	14/35 (40%)
Abtb2	NP_849221.2	H2A	194..>242	CDD:305064	28/47 (60%)
		Ank_4	<498..542	CDD:290365	15/44 (34%)
		ANK	516..670	CDD:238125	62/157 (39%)
		ANK 1	521..550		11/28 (39%)
		ANK repeat	524..565	CDD:293786	14/41 (34%)
		Ank_2	526..633	CDD:289560	45/107 (42%)
		ANK repeat	567..604	CDD:293786	14/36 (39%)
		ANK 2	567..596		10/28 (36%)
		ANK 3	606..635		15/28 (54%)
		ANK repeat	606..631	CDD:293786	13/24 (54%)
		Ank_2	611..>679	CDD:289560	31/71 (44%)
		ANK repeat	649..679	CDD:293786	16/33 (48%)
		ANK 4	649..678		16/32 (50%)
		BTB	836..939	CDD:279045	53/102 (52%)
		BTB	845..946	CDD:197585	51/100 (51%)
		SPOP_C_like	946..>990	CDD:269810	17/44 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	138	1.000	Domainoid score	I4822
eggNOG	1	0.900	-	-		E1_28KA7
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H15904
Inparanoid	1	1.050	597	1.000	Inparanoid score	I949
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49645
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002685
OrthoInspector	1	1.000	-	-		otm43654
orthoMCL	1	0.900	-	-		OOG6_105756
Panther	1	1.100	-	-	LDO	PTHR46071
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5139
SonicParanoid	1	1.000	-	-		X1560
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.860