Protein Alignment CG43980 and Abtb3

DIOPT Version :10

• Sequence 1: NP_001262185.1
• Gene: CG43980 / 2768995
• FlyBaseID: FBgn0264711
• Length: 1549
• Species: Drosophila melanogaster
• Sequence 2: NP_082985.2
• Gene: Abtb3 / 74007
• MGIID: 1921257
• Length: 1109
• Species: Mus musculus
• Alignment Length: 1203
• Identity: 408/1203 - (33%)
• Similarity: 587/1203 - (48%)
• Gaps: 266/1203 - (22%)

  Fly   501 GKAPWSGTGLEDIKLAMLTLRS----QTSSSTYSSLSAGSESSEPARRLG-------------RY 548
            ||.|...| |||     |||.|    ...|...|:||.....|.||...|             |:
Mouse     5 GKKPVVRT-LED-----LTLDSGYGGAADSVRSSNLSLCCSDSHPASPYGGSCWPPLADSMHSRH 63

  Fly   549 SSLETVVTSTSADE--FVWVDSH-NRLV-ELQHPPWSQQCILKVLRNGRCQQQAE----HLAVEA 605
            :|.:||.|:...|.  ......| :||: :|...||:.|.:..:|...|..:...    .|..:|
Mouse    64 NSFDTVNTALVEDSEGLDCAGQHCSRLLPDLDEVPWTLQELELLLLRSRDPRAGPAVPGSLPKDA 128

  Fly   606 VSRLGYLLQRALVRIAREIQRFSAGVGLCSKQEVVGALRVVLSSSLADSCTKACLRSAAMF--AV 668
            :::|..|:.|||||||:|.||.|.....|:|.|:..|:.:|||..||..||.|.|.:.:::  :.
Mouse   129 LAKLSMLVSRALVRIAKEAQRLSLRFAKCTKYEIQSAMEIVLSWGLAAHCTAAALAALSLYNMSS 193

  Fly   669 PGESALKQSKSARAGLQLSVGRFYRWMTDARLGKFIHEYAAVYLCAGIENLLEEI---------A 724
            .|...|.:.||||.||..||||.||||.|:|:...|||:||:||.|.:|:|..:|         .
Mouse   194 AGGDRLGRGKSARCGLTFSVGRVYRWMVDSRVALRIHEHAAIYLTACMESLFRDIYSRVLASGLP 258

  Fly   725 LQCNG------------------------------------------------------------ 729
            ..|:|
Mouse   259 RSCSGPGPGSSSGSGPGPGSGPGAPAADKERETPGGGAASGGPCSAASSASGGSSCCAPPATAAT 323

  Fly   730 ----TTAAA-----------------------LDQSIASSGDVWGLLQPFAHLNAGRIASGALAL 767
                |||.|                       |:.::.:..::||||||:.||..|:.|||.|:|
Mouse   324 AVPPTTATAAVAANHHHHHHTLHEAPKFTVETLEHTVNNDSEIWGLLQPYQHLICGKNASGVLSL 388

  Fly   768 PRWAN-----------------------SLDQVIASSGDFRGHLATCVGSIRELKEKALRTQQEF 809
            |...|                       :::|.:         |||.||||.||.:...|.....
Mouse   389 PESLNLHRDPQRPSKPGELPMFSQSELRTIEQSL---------LATRVGSIAELSDLVSRAMHHL 444

  Fly   810 Q-LAAALSGS----------------ALAALFYFMRCSQLEHTELLAASGCHAGQAQSAAPGGGT 857
            | |.|...|:                ||..|.|||.|.|:|...                |....
Mouse   445 QPLNAKHHGNGTPMHHKQGALYWEPEALYTLCYFMHCPQMEWEN----------------PNVEP 493

  Fly   858 SSAGHHVQELCYERAYVVLPPLAEWLRVAAAHAEHRNAMMIDKDDVMQAARLLLPGVDCPIRPVA 922
            |.....|     ||.::|||||.||:|||.|||.||.:..:|.|||.||||||||||||..|.:.
Mouse   494 SKVNLQV-----ERPFLVLPPLMEWIRVAVAHAGHRRSFSMDSDDVRQAARLLLPGVDCEPRQLK 553

  Fly   923 HDEELPTKKTHFNTAPTVSSTGTGTGSSSCSSPVVSGIGIGIGEDTSELGRRATIGVAFKLLLTG 987
            .|:                        ..|:|..:..:.|       |...:..:|  |::|..|
Mouse   554 ADD------------------------CFCASRKLDAVAI-------EAKFKQDLG--FRMLNCG 585

  Fly   988 RAELLAQAAQLLPPTTRYDTQNSAGLTALMIASIRNDEVALHALLDAGCDPNVEVPPAGSAGYPA 1052
            |.:|:.||..||.| ...:|.:..|:|.||.|.:|.||..:..|||||.|.||||...... ||:
Mouse   586 RTDLVKQAVSLLGP-DGINTMSEQGMTPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPHK-YPS 648

  Fly  1053 IQPDTQHWTALSFAASRANYVALRILLERGGKVEGGARSSEEKCTLTPLQLAAGTGNLEIVALLL 1117
            :.|:|:|||||:||....:...:::||:.|.||||.....||..:.|||||||..||.|:|:|||
Mouse   649 VHPETRHWTALTFAVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFELVSLLL 713

  Fly  1118 AHGANAFLSTQQKDSLCFAGSAQKGCFCAISVAAAHGHRSCLRKLLTHPVSPGTRDVLSLEEMLA 1182
            ..||:..:.|..::.:   .:..:|...:.|.|||||||:..||||..|....: |:|||||:||
Mouse   714 ERGADPLIGTMYRNGI---STTPQGDMNSFSQAAAHGHRNVFRKLLAQPEKEKS-DILSLEEILA 774

  Fly  1183 EG-DVGGVRGSGGPTGAGGPNSASASGNNEDILPLLNKTQIKRLQEAMYHSAENNHLDITIELRK 1246
            || |:...          .|....||.|        :|.:::.|:||||||||:.::|:||::|.
Mouse   775 EGTDLAET----------APPPLCASRN--------SKAKLRALREAMYHSAEHGYVDVTIDIRS 821

  Fly  1247 LGVPWTLHCWMHALSAAHDLRLDAVIDQLLQDFLQVCPDDYSAQFVSECLPLLFNIFR-NKNEGT 1310
            :|||||||.|:.:|..|.......:|..||::|..:..::|:.:.|::.|||:|.|.: :|||..
Mouse   822 IGVPWTLHTWLESLRIAFQQHRRPLIQCLLKEFKTIQEEEYTEELVTQGLPLMFEILKASKNEVI 886

  Fly  1311 TLLLADIFATCFGWETLPPVKEQPPMQPVQGSRIDPKFVNNPELSDVTFRVEGKIFYGHKIVLVT 1375
            :..|..||..|:|...:|.:.|   ::..|.||:||.|:||.|:|||||.|||:.||.||::|.|
Mouse   887 SQQLCVIFTHCYGPYPIPKLTE---IKRKQTSRLDPHFLNNKEMSDVTFLVEGRPFYAHKVLLFT 948

  Fly  1376 ASPRFQSMLSSKLSEGSSTPTVQINDIRYHIFQLVMQFLYCGGCSSLDVAHGDVLELMAAASFFQ 1440
            |||||:::||||.:..::  .::|..::|.|||||||:||.||..||.:.:.:::||::||.|||
Mouse   949 ASPRFKALLSSKPTNDNT--CIEIGYVKYPIFQLVMQYLYYGGPESLLIKNNEIMELLSAAKFFQ 1011

  Fly  1441 LEGLLRYTEARCSEMVDVDNVVAMYIHAKVYNANRLLEFCQCFLLQNMVALLTYDDSVKRLLFAK 1505
            ||.|.|:.|..|::.::.||.|.:|.|||......|..:|:.:.|:||:.|:. :::.|:||:.|
Mouse  1012 LEALQRHCEIICAKSINTDNCVDIYSHAKFLGVTELSAYCEGYFLKNMMVLIE-NEAFKQLLYDK 1075

  Fly  1506 --KIPNHDVLAGLLQTLQNRLKARKPNSGGGLV 1536
              :....|||..|.:||..|:::...:|..|.|
Mouse  1076 NGEGAGQDVLQDLQRTLAIRIQSIHLSSSKGSV 1108

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG43980	NP_001262185.1	Atrophin-1	<270..>428	CDD:460830
		HFD_ABTB2-like	668..763	CDD:467038	46/190 (24%)
		ANKYR	983..>1173	CDD:440430	79/189 (42%)
		ANK repeat	1012..1056	CDD:293786	20/43 (47%)
		ANK repeat	1058..1091	CDD:293786	14/32 (44%)
		ANK repeat	1093..1121	CDD:293786	16/27 (59%)
		ANK repeat	1141..1173	CDD:293786	14/31 (45%)
		BTB_POZ_ABTB2-like	1343..1460	CDD:349606	58/116 (50%)
		BACK_ABTB2_like	1456..1527	CDD:350566	24/72 (33%)
Abtb3	NP_082985.2	HFD_ABTB2-like	193..384	CDD:467038	46/190 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	260..302		2/41 (5%)
		ANKYR	<585..758	CDD:440430	77/177 (44%)
		ANK 1. /evidence=ECO:0000255	608..637		14/28 (50%)
		ANK repeat	611..652	CDD:293786	19/41 (46%)
		ANK repeat	654..685	CDD:293786	14/30 (47%)
		ANK 2. /evidence=ECO:0000255	654..683		12/28 (43%)
		ANK repeat	687..717	CDD:293786	16/29 (55%)
		ANK 3. /evidence=ECO:0000255	692..721		16/28 (57%)
		ANK 4. /evidence=ECO:0000255	735..764		14/28 (50%)
		ANK 5. /evidence=ECO:0000255	830..859		7/28 (25%)
		BTB_POZ_BTBD11	904..1034	CDD:349660	64/134 (48%)
		BACK_BTBD11	1027..1109	CDD:350602	27/83 (33%)