DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG43980 and Abtb2

DIOPT Version :9

Sequence 1:	NP_001262185.1	Gene:	CG43980 / 2768995	FlyBaseID:	FBgn0264711	Length:	1549	Species:	Drosophila melanogaster
Sequence 2:	NP_599230.2	Gene:	Abtb2 / 171440	RGDID:	620724	Length:	1024	Species:	Rattus norvegicus

Alignment Length:	1104	Identity:	397/1104 - (35%)
Similarity:	592/1104 - (53%)	Gaps:	189/1104 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   510 LEDIKL-----AMLTLRSQTSSSTYSSLSAGSESSEPARR-----------LGRYSSLETVVTST 558
            |||:.|     |..:.||.:.||:.|: |....||.|..|           ..|::|.:||.|..
  Rat    12 LEDLTLDSGYGAGDSCRSLSLSSSKSN-SQALNSSAPQHRGAAWWCYSGSMNSRHNSWDTVNTVL 75

  Fly   559 SADEFVWVDSHN---RLVELQHPPWSQQCILKVLRNGRCQQQAEHLAVEAVSRLGYLLQRALVRI 620
            ..|..| .|..:   ||.||:..||::..:.:|||.....::....:.|||.||..||:|||:|:
  Rat    76 PEDPEV-ADLFSRCPRLPELEEFPWTEGDVARVLRKSVGGRRLPSFSAEAVRRLAGLLRRALIRV 139

  Fly   621 AREIQRFSAGVGLCSKQEVVGALRVVLSSSLADSCTKACLRSAAMFAVPGESALKQSKSARAGLQ 685
            |||.||.|.....|::.||..|:|:|.|.:||:||..|.:::.:::::.....|::.||||.||.
  Rat   140 AREAQRLSVLHAKCTRFEVQSAVRLVHSWALAESCALAAVKALSLYSMSAGDGLRRGKSARCGLT 204

  Fly   686 LSVGRFYRWMTDARLGKFIHEYAAVYLCAGIENLLEEIALQC-------------NGTTAAALDQ 737
            .|||||:|||.|.|:...||||||:.|.|.:|||:|||..:.             ...:|.||:.
  Rat   205 FSVGRFFRWMVDTRISVRIHEYAAISLTACMENLVEEIRARVLASQSPDGGGAGGGEVSAEALEM 269

  Fly   738 SIASSGDVWGLLQPFAHLNAGRIASGALALPRWANSLDQVIASSGDFRGH--------------- 787
            .|.:..::||:|||:.||..|:.|:|.|:||.:.:..      :|...||
  Rat   270 VINNDAELWGVLQPYEHLICGKNANGVLSLPAYFSPY------NGGSLGHDERADAYAQLELRTL 328

  Fly   788 ----LATCVGSIRELKEKALRTQQEFQLAAAL-------------------SGSALAALFYFMRC 829
                ||||||||.||.:...|.....|....|                   |..||..|:||:||
  Rat   329 EQSLLATCVGSISELSDLVSRAMHHMQGRHPLCPGTSPARQARQPPQPITWSPDALHTLYYFLRC 393

  Fly   830 SQLEHTELLAASGCHAGQAQSAAPGGGTSSAGHHVQELCYERAYVVLPPLAEWLRVAAAHAEHRN 894
            .|:|..|           ..:..|...|         |..||.:::||||.||:|||..:||||.
  Rat   394 PQMESME-----------NPNLDPPRMT---------LNNERPFMLLPPLMEWMRVAITYAEHRR 438

  Fly   895 AMMIDKDDVMQAARLLLPGVDCPIRPVAH----------DEELPTKKTHFNTAPTVSSTGTGTGS 949
            ::.:|..|:.|||||||||:||..|.:..          |....|::  ||
  Rat   439 SLTVDSGDIRQAARLLLPGLDCEPRQLKPECCFSSFRRLDARAATER--FN-------------- 487

  Fly   950 SSCSSPVVSGIGIGIGEDTSELGRRATIGVAFKLLLTGRAELLAQAAQLLPPTTRYDTQNSAGLT 1014
                               .:||        |::|..||.:|::||.:.|.| ...:|.:..|||
  Rat   488 -------------------QDLG--------FRMLNCGRTDLISQAIEALGP-DGVNTMDDQGLT 524

  Fly  1015 ALMIASIRNDEVALHALLDAGCDPNVEVPPAGSAGYPAIQPDTQHWTALSFAASRANYVALRILL 1079
            .||.|....||..:..|:|||.:.:::| |:.|..:|::.||::|||:|:||....:...:::||
  Rat   525 PLMYACATGDEAMVQMLIDAGANLDIQV-PSNSPRHPSVHPDSRHWTSLTFAVLHGHISVVQLLL 588

  Fly  1080 ERGGKVEGGA-RSSEEKCTLTPLQLAAGTGNLEIVALLLAHGANAFLSTQQKDSLCFAGSAQKGC 1143
            :.|..|||.| .|.|:....||||||:..||.|:|:|||:.||:..||..:.:.:..:......|
  Rat   589 DAGAHVEGSAVNSGEDSYAETPLQLASAAGNYELVSLLLSRGADPLLSMLEANGMASSLHEDMNC 653

  Fly  1144 FCAISVAAAHGHRSCLRKLLTHPVSPGTRDVLSLEEMLAEG----DVGGVRGSGGPTGAGGPNSA 1204
            |   |.:||||||:.||||||.| .....|||||||:||||    |......|.||.
  Rat   654 F---SHSAAHGHRNVLRKLLTQP-QQAKADVLSLEEILAEGVEESDTSSQGSSEGPV-------- 706

  Fly  1205 SASGNNEDILPLLNKTQIKRLQEAMYHSAENNHLDITIELRKLGVPWTLHCWMHALSAAHDLRLD 1269
                       .|::|:.|.||||||:|||:.::|||:|||.|||||.||.|:.:|..:......
  Rat   707 -----------RLSRTRTKALQEAMYYSAEHGYVDITMELRALGVPWKLHIWIESLRTSFSQSRY 760

  Fly  1270 AVIDQLLQDFLQVCPDDYSAQFVSECLPLLFNIFR-NKNEGTTLLLADIFATCFGWETLPPVKEQ 1333
            :|:..||:||..:..::|:.:.|:|.|.|:|:|.: :||:.....||.||..|:|...:|.:
  Rat   761 SVVQGLLRDFSSIKEEEYNEELVTEGLQLMFDILKTSKNDSVLQQLATIFTHCYGTSPIPSI--- 822

  Fly  1334 PPMQPVQGSRIDPKFVNNPELSDVTFRVEGKIFYGHKIVLVTASPRFQSMLSSKL-SEGSSTPTV 1397
            |.::....:|:||.|:||.|:|||||.||||:||.||::|||||.||::::::|. .:|.::.|:
  Rat   823 PEIRKTLPARLDPHFLNNKEMSDVTFLVEGKLFYAHKVLLVTASNRFKTLMTNKSEQDGDNSKTI 887

  Fly  1398 QINDIRYHIFQLVMQFLYCGGCSSLDVAHGDVLELMAAASFFQLEGLLRYTEARCSEMVDVDNVV 1462
            :|:||:|||||::||:||.||..|:::...|:|:|::||:.|||:.|.|:.|..||:.:.|::.|
  Rat   888 EISDIKYHIFQMLMQYLYYGGTESMEIPTADILQLLSAANLFQLDALQRHCEILCSQTLSVESAV 952

  Fly  1463 AMYIHAKVYNANRLLEFCQCFLLQNMVALLTYDDSVKRLLFAK--KIPNHDVLAGLLQTLQNRL 1524
            ..|.:||::||..|..||:.|.|::|.|||. .|:.::|::.:  |:...|.|..|..||..|:
  Rat   953 NTYKYAKIHNAPELALFCEGFFLKHMKALLE-QDAFRQLIYGRSSKVQGLDPLQDLQSTLAERV 1015

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43980	NP_001262185.1	Med25_SD1	265..424	CDD:288132
		H2A	675..>728	CDD:305064	30/65 (46%)
		ANK	1006..1163	CDD:238125	63/157 (40%)
		ANK repeat	1012..1056	CDD:293786	16/43 (37%)
		Ank_2	1016..1122	CDD:289560	44/106 (42%)
		ANK repeat	1058..1091	CDD:293786	13/33 (39%)
		ANK repeat	1093..1121	CDD:293786	14/27 (52%)
		ANK repeat	1141..1173	CDD:293786	16/31 (52%)
		BTB	1350..1446	CDD:279045	50/96 (52%)
		BTB	1356..1449	CDD:197585	47/93 (51%)
		SPOP_C_like	1456..>1492	CDD:269810	14/35 (40%)
Abtb2	NP_599230.2	H2A	194..>242	CDD:305064	28/47 (60%)
		Ank_4	<498..542	CDD:290365	16/44 (36%)
		ANK	516..670	CDD:238125	63/157 (40%)
		ANK 1	521..550		12/28 (43%)
		ANK repeat	522..565	CDD:293786	16/43 (37%)
		Ank_2	526..633	CDD:289560	45/107 (42%)
		ANK repeat	567..604	CDD:293786	14/36 (39%)
		ANK 2	567..596		10/28 (36%)
		ANK 3	606..635		15/28 (54%)
		ANK repeat	606..631	CDD:293786	13/24 (54%)
		Ank_2	611..>679	CDD:289560	31/71 (44%)
		ANK 4	649..678		16/32 (50%)
		BTB	836..939	CDD:279045	52/102 (51%)
		BTB	845..946	CDD:197585	50/100 (50%)
		SPOP_C_like	946..>990	CDD:269810	17/44 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	135	1.000	Domainoid score	I4844
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H15904
Inparanoid	1	1.050	583	1.000	Inparanoid score	I973
OMA	1	1.010	-	-		QHG49645
OrthoDB	1	1.010	-	-		D201821at33208
OrthoFinder	1	1.000	-	-		FOG0002685
OrthoInspector	1	1.000	-	-		otm45728
orthoMCL	1	0.900	-	-		OOG6_105756
Panther	1	1.100	-	-	LDO	PTHR46071
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1560
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.980