Protein Alignment rho-5 and Rhbdf2

DIOPT Version :8

• Sequence 1: NP_995679.1
• Gene: rho-5 / 2768944
• FlyBaseID: FBgn0041723
• Length: 1429
• Species: Drosophila melanogaster
• Sequence 2: NP_001161152.1
• Gene: Rhbdf2 / 217344
• MGIID: 2442473
• Length: 827
• Species: Mus musculus
• Alignment Length: 918
• Identity: 274/919 (30%)
• Similarity: 424/919 (46%)
• Gaps: 189/919 (21%)

  Fly   436 SSMVSVQAKRLEG----GGNMAVPPGSNQHQLYRSQMASNPRLQHIHHQTQQHQSLQVLPQPQNH 496
            |::.||...||:.    ..::.:||..:|....:..|....|....:.::   .|||   :|:..
Mouse     9 SNLPSVSGSRLQSRKPPNLSITIPPPESQAPGEQDSMLPERRKNPAYLKS---VSLQ---EPRGR 67

  Fly   497 -HLSCKKRIG--------MYMRRTTSQFFGVEPSTEAADCALWQGR----HRRLAIRC---FGMF 545
             ....:||.|        ..:|::|:|:|||...        |:|:    |||....|   :|..
Mouse    68 WQEGAEKRPGFRRQASLSQSIRKSTAQWFGVSGD--------WEGKRQNWHRRSLHHCSVHYGRL 124

  Fly   546 ----DTELEYHMQQ----------------------AIGGGNEDAGQSNGTNGNYAPDRPDILPV 584
                ..|||...|:                      |.|.......:.:..:..:.|..|.:|.:
Mouse   125 KASCQRELELPSQEVPSFQGTESPKPCKMPKIVDPLARGRAFRHPDEVDRPHAAHPPLTPGVLSL 189

  Fly   585 QDAIGMDMTMSGDSRRQKCYTNRDFLAGEFVERKASVGYM-FVAMVSYLVHMFNKRRPIQMHRVR 648
            .....:....|...||                ::.||.:| |.|..:.|    ..|..:.....|
Mouse   190 TSFTSVRSGYSHLPRR----------------KRISVAHMSFQAAAALL----KGRSVLDATGQR 234

  Fly   649 CPWQWSRSFA-PIHVQSHSNQQTDADGCLTDGLEAIIDDEVFFDSPCEITTSAVND--ESSDIGR 710
            |. ...|||| |      |..:.||    .||.:..  |..||..  |..:|..:|  ||..:..
Mouse   235 CR-HVKRSFAYP------SFLEEDA----VDGADTF--DSSFFSK--EEMSSMPDDVFESPPLSA 284

  Fly   711 QAAK--PRPCADQSGVGVSVYMAERQQNGWRTSALNSGGNATSDINLTGDQSSHQPGAAHIPLCS 773
            ...:  |...:..|..||.:.:.|           .|||.|..            ||.
Mouse   285 SYFRGVPHSASPVSPDGVHIPLKE-----------YSGGRALG------------PGT------- 319

  Fly   774 SVSSQMQPAMRSSHSTTSTCNRGNRITAQLLD------------GVLEN-SRRPPLRCIKYFSVN 825
                                .||.||.:::..            ||:.| ..|...|.|......
Mouse   320 --------------------QRGKRIASKVKHFAFDRKKRHYGLGVVGNWLNRSYRRSISSTVQR 364

  Fly   826 DLDDRTDHRPFFTYWINTVQVVVLILSIICYGIAPIGIGSEQKTGQVLVTSLSLQTVQHVEQRNL 890
            .|:....|||:||||:..|.:::.:|.|..|||||:|......|..||......::|::::|.|.
Mouse   365 QLESFDSHRPYFTYWLTFVHIIITLLVICTYGIAPVGFAQHVTTQLVLKNRGVYESVKYIQQENF 429

  Fly   891 WIGPRNIDLVHMGAKFAACMRRDIKITEVVTKTRRHERETACCIRNDDSGCVQSSQAECSIRGLY 955
            ||||.:|||:|:||||:.|:|:|.:|.::|.:.|..||.:.||::||.|||:|:.:.:||
Mouse   430 WIGPSSIDLIHLGAKFSPCIRKDQQIEQLVRRERDIERTSGCCVQNDRSGCIQTLKKDCS----- 489

  Fly   956 PTKSISTWKKWSPSESGPGGRI-------SGSVCGLDPKFCDAPASIAPYEWPDDITKWPICRKT 1013
              ::::|:.||. :::||..:.       |..||..||:.|:.|||...:.|||||||||||
Mouse   490 --ETLATFVKWQ-NDTGPSDKSDLSQKQPSAVVCHQDPRTCEEPASSGAHIWPDDITKWPIC--- 548

  Fly  1014 NSFTQRYRYKDHTS-EHMVCEVIGHPCCTGLYGECRITTREYCDFIKGYFHEEASLCSQISCLNN 1077
               |::.: .:||. .|:.|::.|.|||.|..|.|.|||||||:|:.|||||:|:||||:.||:.
Mouse   549 ---TEQAQ-SNHTGLLHIDCKIKGRPCCIGTKGSCEITTREYCEFMHGYFHEDATLCSQVHCLDK 609

  Fly  1078 VCGMFPFISVETPDQLYRLLTSLCMHAGILHLAITLIFQHLFLADLERLIGTVRTAIVYIMSGFA 1142
            |||:.||::.|.|||.||:..||.:||||:|..::::||...|.|||:|.|..|.:|::|:||..
Mouse   610 VCGLLPFLNPEVPDQFYRIWLSLFLHAGIVHCLVSVVFQMTILRDLEKLAGWHRISIIFILSGIT 674

  Fly  1143 GNLTSAILVPHRPEVGPSASLSGVVASLIALLVWMHWKYLHKPHIALFKLLLLCSVLVGIGTLPY 1207
            |||.|||.:|:|.||||:.|..|::|.|...| :..|:.|.:|..|.|.|..:...|...|.||:
Mouse   675 GNLASAIFLPYRAEVGPAGSQFGLLACLFVEL-FQSWQLLERPWKAFFNLSAIVLFLFICGLLPW 738

  Fly  1208 QLNFLGLLAGVICGCLLTMSLVPFTTFSKYGRKKKINLIWTCVLFHVVVYTAMIVTFYIHPSEFH 1272
             ::.:..:.|.:.|.||..:.:|:.||....:.:|..||...:|....::.::::..||:|..:.
Mouse   739 -IDNIAHIFGFLSGMLLAFAFLPYITFGTSDKYRKRALILVSLLVFAGLFASLVLWLYIYPINWP 802

  Fly  1273 SISFVDMF 1280
            .|.::..|
Mouse   803 WIEYLTCF 810

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
rho-5	NP_995679.1	Rhomboid	1090..1225	CDD:279958	56/135 (41%)
Rhbdf2	NP_001161152.1	Rhomboid_SP	98..304	CDD:289371	51/249 (20%)
		Rhomboid	619..760	CDD:279958	57/143 (40%)
		GtrA	719..803	CDD:303012	21/85 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
eggNOG	1	0.900				E1_COG0705
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000				FOG0002033
OrthoInspector	1	1.000				T615981
orthoMCL	1	0.900				OOG5_127224
Panther	1	1.100			LDO	PTHR45965
Phylome	1	0.910		0.800	Consistency score
RoundUp	0	0.000	Not matched by this tool.
TreeFam	1	0.960
	7	6.770