Protein Alignment rho-5 and Rhbdf2

DIOPT Version :9

• Sequence 1: NP_995679.1
• Gene: rho-5 / 2768944
• FlyBaseID: FBgn0041723
• Length: 1429
• Species: Drosophila melanogaster
• Sequence 2: XP_030101763.1
• Gene: Rhbdf2 / 217344
• MGIID: 2442473
• Length: 853
• Species: Mus musculus
• Alignment Length: 936
• Identity: 274/936 - (29%)
• Similarity: 431/936 - (46%)
• Gaps: 199/936 - (21%)

  Fly   436 SSMVSVQAKRLEG----GGNMAVPPGSNQHQLYRSQMASNPRLQHIHHQTQQHQSLQVLPQPQNH 496
            |::.||...||:.    ..::.:||..:|....:..|....|....:.::   .|||   :|:..
Mouse     9 SNLPSVSGSRLQSRKPPNLSITIPPPESQAPGEQDSMLPERRKNPAYLKS---VSLQ---EPRGR 67

  Fly   497 -HLSCKKRIG--------MYMRRTTSQFFGVEPSTEAADCALWQGR----HRRLAIRC---FGMF 545
             ....:||.|        ..:|::|:|:|||...        |:|:    |||....|   :|
Mouse    68 WQEGAEKRPGFRRQASLSQSIRKSTAQWFGVSGD--------WEGKRQNWHRRSLHHCSVHYG-- 122

  Fly   546 DTELEYHMQQAIGGGNEDAGQSNGTNGNYAPDRPDILPVQDAIGMDMTMSGDSRRQKCYTN---- 606
              .|:...|:.:...:::.....||........|.:.|::        :.|..|..:...|
Mouse   123 --RLKASCQRELELPSQEVPSFQGTESPKPCKMPKVGPLE--------VMGSKRLSQGLGNIVHP 177

  Fly   607 ------------RDFLAGEFVERKASV------GYM----FVAMVSYLVHMFNKRRPIQMHR--- 646
                        |.|...:.|:|..:.      |.:    |.::.|...|:..::|....|.
Mouse   178 HLLQIVDPLARGRAFRHPDEVDRPHAAHPPLTPGVLSLTSFTSVRSGYSHLPRRKRISVAHMSFQ 242

  Fly   647 ----------------VRCPWQWSRSFA-PIHVQSHSNQQTDADGCLTDGLEAIIDDEVFFDSPC 694
                            .||. ...|||| |      |..:.||    .||.:..  |..||..
Mouse   243 AAAALLKGRSVLDATGQRCR-HVKRSFAYP------SFLEEDA----VDGADTF--DSSFFSK-- 292

  Fly   695 EITTSAVND--ESSDIGRQAAK--PRPCADQSGVGVSVYMAERQQNGWRTSALNSGGNATSDINL 755
            |..:|..:|  ||..:.....:  |...:..|..||.:.:.|           .|||.|..
Mouse   293 EEMSSMPDDVFESPPLSASYFRGVPHSASPVSPDGVHIPLKE-----------YSGGRALG---- 342

  Fly   756 TGDQSSHQPGAAHIPLCSSVSSQMQPAMRSSHSTTSTCNRGNRITAQLLD------------GVL 808
                    ||.                           .||.||.:::..            ||:
Mouse   343 --------PGT---------------------------QRGKRIASKVKHFAFDRKKRHYGLGVV 372

  Fly   809 EN-SRRPPLRCIKYFSVNDLDDRTDHRPFFTYWINTVQVVVLILSIICYGIAPIGIGSEQKTGQV 872
            .| ..|...|.|.......|:....|||:||||:..|.:::.:|.|..|||||:|......|..|
Mouse   373 GNWLNRSYRRSISSTVQRQLESFDSHRPYFTYWLTFVHIIITLLVICTYGIAPVGFAQHVTTQLV 437

  Fly   873 LVTSLSLQTVQHVEQRNLWIGPRNIDLVHMGAKFAACMRRDIKITEVVTKTRRHERETACCIRND 937
            |......::|::::|.|.||||.:|||:|:||||:.|:|:|.:|.::|.:.|..||.:.||::||
Mouse   438 LKNRGVYESVKYIQQENFWIGPSSIDLIHLGAKFSPCIRKDQQIEQLVRRERDIERTSGCCVQND 502

  Fly   938 DSGCVQSSQAECSIRGLYPTKSISTWKKWSPSESGPGGRI-------SGSVCGLDPKFCDAPASI 995
            .|||:|:.:.:||       ::::|:.||. :::||..:.       |..||..||:.|:.|||.
Mouse   503 RSGCIQTLKKDCS-------ETLATFVKWQ-NDTGPSDKSDLSQKQPSAVVCHQDPRTCEEPASS 559

  Fly   996 APYEWPDDITKWPICRKTNSFTQRYRYKDHTS-EHMVCEVIGHPCCTGLYGECRITTREYCDFIK 1059
            ..:.|||||||||||      |::.: .:||. .|:.|::.|.|||.|..|.|.|||||||:|:.
Mouse   560 GAHIWPDDITKWPIC------TEQAQ-SNHTGLLHIDCKIKGRPCCIGTKGSCEITTREYCEFMH 617

  Fly  1060 GYFHEEASLCSQISCLNNVCGMFPFISVETPDQLYRLLTSLCMHAGILHLAITLIFQHLFLADLE 1124
            |||||:|:||||:.||:.|||:.||::.|.|||.||:..||.:||||:|..::::||...|.|||
Mouse   618 GYFHEDATLCSQVHCLDKVCGLLPFLNPEVPDQFYRIWLSLFLHAGIVHCLVSVVFQMTILRDLE 682

  Fly  1125 RLIGTVRTAIVYIMSGFAGNLTSAILVPHRPEVGPSASLSGVVASLIALLVWMHWKYLHKPHIAL 1189
            :|.|..|.:|::|:||..|||.|||.:|:|.||||:.|..|::|.|...| :..|:.|.:|..|.
Mouse   683 KLAGWHRISIIFILSGITGNLASAIFLPYRAEVGPAGSQFGLLACLFVEL-FQSWQLLERPWKAF 746

  Fly  1190 FKLLLLCSVLVGIGTLPYQLNFLGLLAGVICGCLLTMSLVPFTTFSKYGRKKKINLIWTCVLFHV 1254
            |.|..:...|...|.||: ::.:..:.|.:.|.||..:.:|:.||....:.:|..||...:|...
Mouse   747 FNLSAIVLFLFICGLLPW-IDNIAHIFGFLSGMLLAFAFLPYITFGTSDKYRKRALILVSLLVFA 810

  Fly  1255 VVYTAMIVTFYIHPSEFHSISFVDMF 1280
            .::.::::..||:|..:..|.::..|
Mouse   811 GLFASLVLWLYIYPINWPWIEYLTCF 836

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
rho-5	NP_995679.1	Rhomboid	1090..1225	CDD:279958	55/134 (41%)
Rhbdf2	XP_030101763.1	Rhomboid_SP	98..328	CDD:372211	49/264 (19%)
		Rhomboid	648..788	CDD:366759	57/141 (40%)
		MFS	746..>836	CDD:391944	21/90 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167834619
Domainoid	1	1.000	116	1.000	Domainoid score	I5939
eggNOG	1	0.900	-	-		E1_COG0705
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002903
OrthoInspector	1	1.000	-	-		otm44364
orthoMCL	1	0.900	-	-		OOG6_100562
Panther	1	1.100	-	-	LDO	PTHR45965
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X418
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.700