DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG33298 and ALA2

DIOPT Version :9

Sequence 1:	NP_995666.1	Gene:	CG33298 / 2768929	FlyBaseID:	FBgn0032120	Length:	1517	Species:	Drosophila melanogaster
Sequence 2:	NP_568633.2	Gene:	ALA2 / 834447	AraportID:	AT5G44240	Length:	1139	Species:	Arabidopsis thaliana

Alignment Length:	1273	Identity:	363/1273 - (28%)
Similarity:	582/1273 - (45%)	Gaps:	297/1273 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   253 NKIRTTKYTLLSFIPKNLLEQFHRVANLYFIFIVLLN-W-----VPEISAFGKEVAMIPVLFVLG 311
            |:|...||||.:|:||||.|||.|..|.||:.|..|. |     |...|.:|      |::|:..
plant    52 NRISNRKYTLWNFLPKNLWEQFSRFMNQYFLLIACLQLWSLITPVNPASTWG------PLIFIFA 110

  Fly   312 VTAVKDLFEDRRRRASDKRINNTTCRVYDGETERYKKVKWQELRVGDIVHLSNNETVPADILLLR 376
            |:|.|:.::|..|..|||:.|..  .|:..:....|.::.|:::||:||.|..|:.||.|::||.
plant   111 VSASKEAWDDYHRYLSDKKANEK--EVWIVKQGIKKHIQAQDIQVGNIVWLRENDEVPCDLVLLG 173

  Fly   377 TSDPQGVCYIDTCDLDGETNLKRREV--------VRGFEEMQSIF---VPSKFVSRVEADAPTTK 430
            |||||||||::|..|||||:||.|.:        :....:|:.:.   ||.|.:.|.:|:.
plant   174 TSDPQGVCYVETAALDGETDLKTRVIPSACVGIDLELLHKMKGVIECPVPDKDIRRFDANM---- 234

  Fly   431 LYRFHGALIHP--TGERVPISTECLLLRESRLKNTDYIEGIVVYAGHETKSMLNN--SGPRYKR- 490
                  .|..|  ..:...::.:..||:...|:||::..|:.||.|::||..::.  :.|:...
plant   235 ------RLFPPFIDNDVCSLTIKNTLLQSCYLRNTEWACGVSVYTGNQTKLGMSRGIAEPKLTAM 293

  Fly   491 -SQVEQQMNIDVIWCVIILLILCVVGAI-----GCRMWLSSFTHFP--VPYLPPNKLTANMESMW 547
             :.:::......::.::::|:|.:.|.:     ..:.|   :..:|  .|:         .|.:.
plant   294 DAMIDKLTGAIFVFQIVVVLVLGIAGNVWKDTEARKQW---YVQYPEEAPW---------YELLV 346

  Fly   548 IFWTYIVILQVMIPLSLYVTIELCKILQVFHIHNNVDLFDAETNKQTECRAMNITEELGQIQHIF 612
            |...:.::..:|||:|:.|:::|.|.|....|..:|::.|.||...:......|:|:|||:::|.
plant   347 IPLRFELLCSIMIPISIKVSLDLVKGLYAKFIEWDVEMIDQETGTASYAANTAISEDLGQVEYIL 411

  Fly   613 TDKTGTLTENKMIFRRCVVNGSDYNHPPSELEKIYSKPGAPAPPLIPNDNLNSDM---AQLTQGT 674
            ||||||||:||||||||.:.|..|.                        |.|.|.   |||...
plant   412 TDKTGTLTDNKMIFRRCCIGGIFYG------------------------NENGDALKDAQLLNA- 451

  Fly   675 YLTPHAQRIQEFLVVLAICNTVIVGAAPHRDMMNASGIIEVQQIGNSPANLKHGKQRQKLLASST 739
             :|..:..:..||.|:||||||
plant   452 -ITSGSTDVIRFLTVMAICNTV------------------------------------------- 472

  Fly   740 STTTTTTIINGPTTQPQVVSIPADRYIRLAESRSVTPSPPPNLLFALPAQSHQPTLSPISSSAES 804
                                                          ||.|
plant   473 ----------------------------------------------LPVQ--------------- 476

  Fly   805 SPNSESESPSPPMKNKSLSNSISPTGRAKAVINSKITSIATFLNAKTQGKRMKLPSSKTGTIYRT 869
                                                                    ||.|.|
plant   477 --------------------------------------------------------SKAGDI--- 482

  Fly   870 ADGRPLYEAESPDELALVNAAYSYDCCLLNRSPNQILVSMPMAGATREYEILKVLPFDSSRKCMS 934
                 :|:|:|.||.|||.||.......:.::.|  |:.:...|:...||:|::|.|.|.||.||
plant   483 -----VYKAQSQDEDALVIAASKLHMVFVGKNAN--LLEIRFNGSVIRYEVLEILEFTSDRKRMS 540

  Fly   935 IVVRQIGSQEIVLYTKGADSSIMPVLVPCSHNSPEGILREQTQQL---LDRYAREGLRILVMAKR 996
            :||:...:.:|:|.:||||.:|:|.       :..|   :||:.:   ::.|::.|||.|.:|.|
plant   541 VVVKDCQNGKIILLSKGADEAILPY-------ARAG---QQTRTIGDAVEHYSQLGLRTLCLAWR 595

  Fly   997 TLNSADYTDWWARHQEIEMSLENRERRLRDSFAKLESNLTLLGATGIEDRLQDGVPETIASLLSA 1061
            .|...:|.:|..:.:|....|.:||.|:.:...:||.:|.:||.|.|||||||||||||.:|..|
plant   596 ELEENEYLEWSVKFKEASSLLVDREWRIAEVCQRLEHDLYILGVTAIEDRLQDGVPETIETLRKA 660

  Fly  1062 GISVWVLTGDKPETAINIAYSAKLFTQQM--ELIRLTARSRDAAETAINFYLTDMENDKTTSTLG 1124
            ||:.|:|||||..|||.||.|....:.:.  :|:.:..::.:....::...|..|   :.|::
plant   661 GINFWMLTGDKQNTAIQIALSCNFISPEPKGQLLMIDGKTEEDVSRSLERVLLTM---RITAS-- 720

  Fly  1125 YGQSLRKKQRALVVDGKTLTFILDPKSKLILPFLRLSKRCASVLCCRSTPLQKAYLVKVVKEELN 1189
                 ..|..|.|:||..|...|....|   .|:.|:....:.:|||.||.|||.||:::| ..:
plant   721 -----EPKDVAFVIDGWALEIALKHHRK---DFVELAILSRTAICCRVTPSQKAQLVEILK-SCD 776

  Fly  1190 LRTLAIGDGANDVSMIQMADVGVGISGQEGMQAVMAADFTLPRFRYLERLLLAHGYWCYDRLSRM 1254
            .||||||||.|||.|||.||:||||||:||:||..|||:::.|||:|:||:|.||.:.|:|.:.:
plant   777 YRTLAIGDGGNDVRMIQQADIGVGISGREGLQAARAADYSIGRFRFLKRLILVHGRYSYNRTAFL 841

  Fly  1255 ILYFFYKNAAFVFLIFWYQLYCGFSGQVMMDQMYLMLYNLIFTSLPPLAIGVYDKRVAEDLLLKN 1319
            ..|.|||:....|:..::....|.||..:.:.:.||.||:.:||:|.| :.|.||.::|..::::
plant   842 SQYSFYKSLLICFIQIFFSFISGVSGTSLFNSVSLMAYNVFYTSVPVL-VSVIDKDLSEASVMQH 905

  Fly  1320 PYLYKNGRLGVAYRPHDFWLILLDALYQSLVIFFVALCAYAESDVGIWEFGTTITASCLFANLVH 1384
            |.:....:.|....|..|......:|:.::::|.:.:.|||.....:.|.|....:.|::.....
plant   906 PQILFYCQAGRLLNPSTFAGWFGRSLFHAIIVFVITIHAYAYEKSEMEELGMVALSGCIWLQAFV 970

  Fly  1385 CAIEIRSWTVLHVLSIVLSLGSFYLFAIVYDSVCMNCFGVRSSYWVIFVCFASAVHWLVIMLSTV 1449
            .|.|..|:|||..|||..:|..||....::.::..:     ..|.::|...:...:|:.:.|...
plant   971 VAQETNSFTVLQHLSIWGNLVGFYAINFLFSAIPSS-----GMYTIMFRLCSQPSYWITMFLIVG 1030

  Fly  1450 VAVLPRLLLTTVRISLCPDDSTKVILQSKRERSRGEAL 1487
            ..:.|...|...|.:..|   :|:.:..:.||..|..|
plant  1031 AGMGPIFALKYFRYTYRP---SKINILQQAERMGGPIL 1065

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33298	NP_995666.1	PhoLip_ATPase_N	249..299	CDD:292826	23/51 (45%)
		ATPase-Plipid	250..1473	CDD:273734	358/1257 (28%)
		E1-E2_ATPase	302..>394	CDD:278548	37/91 (41%)
		Cation_ATPase	<880..965	CDD:289987	31/84 (37%)
		HAD_like	<1177..1240	CDD:304363	39/62 (63%)
		PhoLip_ATPase_C	1223..1468	CDD:292829	65/244 (27%)
ALA2	NP_568633.2	PhoLip_ATPase_N	37..100	CDD:292826	22/47 (47%)
		ATPase-Plipid	50..1056	CDD:273734	359/1262 (28%)
		E1-E2_ATPase	105..>193	CDD:278548	38/89 (43%)
		Cation_ATPase	469..565	CDD:289987	43/265 (16%)
		HAD_like	<762..799	CDD:304363	23/37 (62%)
		PhoLip_ATPase_C	810..1049	CDD:292829	66/247 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0206
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53737
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	1	1.000	-	-		FOG0000076
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	6	5.790