Protein Alignment CG33298 and Atp10d

DIOPT Version :10

• Sequence 1: NP_995666.1
• Gene: CG33298 / 2768929
• FlyBaseID: FBgn0032120
• Length: 1517
• Species: Drosophila melanogaster
• Sequence 2: NP_700438.3
• Gene: Atp10d / 231287
• MGIID: 2450125
• Length: 1469
• Species: Mus musculus
• Alignment Length: 1464
• Identity: 573/1464 - (39%)
• Similarity: 824/1464 - (56%)
• Gaps: 224/1464 - (15%)

  Fly   170 PAREPSAPTS-ATGGR----------GHSRQASRSESIYTLRRTEAPPW----WKRLTLCNYNTG 219
            ||...|||.| .|.|.          |..|....:.|...|..||...|    |:||   ::...
Mouse    12 PALWISAPFSFGTLGSEVTPCWDERPGRDRSPEPAGSPCVLGMTELLQWARHHWRRL---SHGRA 73

  Fly   220 DKFEERSY----------------------RTVVPNHTVPPKTPKRDHPNGQFVGNKIRTTKYTL 262
            ...:||.|                      |.|:|:  :.....:.:..:|.:|.|:||||||||
Mouse    74 QGEDERPYNYASLLACGGKSSRTPRPAGKHRVVIPH--LQCFKDEYERFSGTYVNNRIRTTKYTL 136

  Fly   263 LSFIPKNLLEQFHRVANLYFIFIVLLNWVPEISAFGKEVAMIPVLFVLGVTAVKDLFEDRRRRAS 327
            |:|:|:||.|||||.|||||:|:|:|||||.:.||.||:.|:|::.||.:.|:||..||.|:...
Mouse   137 LNFVPRNLFEQFHRAANLYFLFLVVLNWVPLVEAFQKEITMLPLVVVLTIIAIKDGLEDYRKYKI 201

  Fly   328 DKRINNTTCRVYDGETERYKKVKWQELRVGDIVHLSNNETVPADILLLRTSDPQGVCYIDTCDLD 392
            ||:|||...:||..:.::|....|:.:.|||.:.||.||.:|||::||.::||.|:|:|:|..||
Mouse   202 DKQINNLITKVYSRKEKKYIDCCWKNVTVGDFIRLSCNEIIPADMVLLFSTDPDGICHIETSGLD 266

  Fly   393 GETNLKRREVVRGFEEMQSIFVPSKFVSRVEADAPTTKLYRFHGALIHPTGERVPISTECLLLRE 457
            ||:|||:|:||||:.|..|...|.||.||:|.::|...|.||.|.|.|...|||.:|.|.||||.
Mouse   267 GESNLKQRQVVRGYTEQDSEVDPEKFSSRIECESPNNDLSRFRGFLEHANKERVGLSKENLLLRG 331

  Fly   458 SRLKNTDYIEGIVVYAGHETKSMLNNSGPRYKRSQVEQQMNIDVIWCVIILLILCVVGAIGCRMW 522
            ..::||:.:.|||||||||||:||||||||||||::|::.|.||:|||::|:::|:.||:|..:|
Mouse   332 CTIRNTEAVVGIVVYAGHETKAMLNNSGPRYKRSKLERRANTDVLWCVLLLIVMCLTGALGHGIW 396

  Fly   523 LSSFTH---FPVPYLPPNKLTANMESMWIFWTYIVILQVMIPLSLYVTIELCKILQVFHIHNNVD 584
            ||.:.:   |.:|......::..:...::|||.|::|||:||:||||:||:.|:.|::.|.::||
Mouse   397 LSRYENMLFFNIPEPDGRVISPVLTGFYVFWTMIILLQVLIPISLYVSIEIVKLGQIYFIQSDVD 461

  Fly   585 LFDAETNKQTECRAMNITEELGQIQHIFTDKTGTLTENKMIFRRCVVNGSDYNHPP--------- 640
            .::.:.:...:|||:||||:|||||::|:|||||||||||:||||.|.|.||.|..
Mouse   462 FYNEKMDSTIQCRALNITEDLGQIQYLFSDKTGTLTENKMVFRRCSVAGFDYCHEENAKRLESYQ 526

  Fly   641 ---SELEKI----------YSKPGAPAPPLIPNDNLNSDMAQLT---------QGTYLTPHAQR- 682
               ||.|:.          .::|.|.....:|:..|....|||:         :|:...||:::
Mouse   527 EAVSEEEECTDTLGGSLSNMARPRAQGCRTVPSGPLGKPSAQLSGSTSAVGNGEGSGEVPHSRQA 591

  Fly   683 --------------------------------------------IQEFLVVLAICNTVIVGAAPH 703
                                                        |.:|.:.|||||||:|.|.
Mouse   592 AFSSPMETDVVPDTRLLDKFSQLTPQLLTGLDGTAQSSPLETLYIMDFFIALAICNTVVVSAP-- 654

  Fly   704 RDMMNASGIIEVQQIGNSPANLKHGKQRQKLLASSTSTTTTTTIINGPTTQPQVVSIPADRYIRL 768
                            |.|        |||:..||.......::               :....:
Mouse   655 ----------------NQP--------RQKIGLSSLGGMPIKSL---------------EEIKNI 680

  Fly   769 AESRSVTPSPPPNLLFALPAQSHQPTLSPISSSAESSPNSESESPSPPMKNKSLSNSISPTGRAK 833
            .:..||..|..|:|.....:.|..|.......|..|.|..     ||||:::|......|
Mouse   681 FQKLSVRRSSSPSLASGKDSSSGTPCAFVSRISFFSRPKL-----SPPMEDESSQMDEIP----- 735

  Fly   834 AVINSKITSIATFLNAKTQGKRMKLPSSKTGTIYRTADGRP------LYEAESPDELALVNAAYS 892
                 :.::.|.....:.|.:.:.|..|....:    .|.|      .||||||||.|||.||.:
Mouse   736 -----QASNSACCTETEAQNRAVGLSVSSAEAL----SGPPPSASNLCYEAESPDEAALVYAARA 791

  Fly   893 YDCCLLNRSPNQILVSMPMAGATREYEILKVLPFDSSRKCMSIVVRQIGSQEIVLYTKGADSSIM 957
            |.|.|.:|:|.|::|.....|:. .:::|.:|||||.||.||:|||...|:::|:|||||||.||
Mouse   792 YRCTLQSRTPEQVMVDFAALGSL-TFQLLHILPFDSVRKRMSVVVRHPLSKQVVVYTKGADSVIM 855

  Fly   958 PVLVPCSHN--SPEG--ILREQTQQLLDRYAREGLRILVMAKRTLNSADYTDWWARHQEIEMSLE 1018
            .:|...:.:  :||.  |:||:||:.||.||:.|||.|.:||:.::..:|.:|...|...|.|::
Mouse   856 ELLSVAASDGTNPEQQMIIRERTQRHLDEYAKRGLRTLCVAKKVMSDTEYAEWLRNHFLAETSID 920

  Fly  1019 NRERRLRDSFAKLESNLTLLGATGIEDRLQDGVPETIASLLSAGISVWVLTGDKPETAINIAYSA 1083
            |||..|.:|..:||:.||||||||||||||:||||:|.:|..|||.:|:|||||.|||:||||:.
Mouse   921 NREELLVESAMRLENKLTLLGATGIEDRLQEGVPESIEALHQAGIKIWMLTGDKQETAVNIAYAC 985

  Fly  1084 KLFTQQMELIRLTARSRDAAETAINFYLTDMEN---------------DKTTSTLGYGQSLRKKQ 1133
            ||.....:|..|..:|:||....::..|.:::.               .:.:...|.|::
Mouse   986 KLLEPDDKLFILNTQSQDACGMLMSAILEELQKRAQVSPELASSRKNFPQPSDAQGQGRA----- 1045

  Fly  1134 RALVVDGKTLTFILDPKSKLILPFLRLSKRCASVLCCRSTPLQKAYLVKVVKEELNLRTLAIGDG 1198
             .||:.||||.|.|  :..|...||.|:..|.:|:|||:|||||:.:||:|:...::.||.||||
Mouse  1046 -GLVITGKTLEFAL--QESLQRQFLELTAWCQAVICCRATPLQKSEVVKLVRNHHHVLTLPIGDG 1107

  Fly  1199 ANDVSMIQMADVGVGISGQEGMQAVMAADFTLPRFRYLERLLLAHGYWCYDRLSRMILYFFYKNA 1263
            ||||||||:||:|:|:|||||||||||:||.:.:||:|.:|||.||:|||.|||.|||||||||.
Mouse  1108 ANDVSMIQVADIGIGVSGQEGMQAVMASDFAISQFRHLSKLLLVHGHWCYTRLSNMILYFFYKNV 1172

  Fly  1264 AFVFLIFWYQLYCGFSGQVMMDQMYLMLYNLIFTSLPPLAIGVYDKRVAEDLLLKNPYLYKNGRL 1328
            |:|.|:||||.:|||||..|.|...|:.:||:|||:||:..||.:|.|:.:.||:.|.||::|:.
Mouse  1173 AYVNLLFWYQFFCGFSGTSMTDYWVLIFFNLLFTSVPPIIYGVLEKDVSAETLLQLPELYRSGQR 1237

  Fly  1329 GVAYRPHDFWLILLDALYQSLVIFFVALCAYAESDVGIWEFGTTITASCLFANLVHCAIEIRSWT 1393
            ...|.|..||:.||||.|||||.|||....|..||:.|:.||..:..:.||..|:|..||.:|.|
Mouse  1238 SEEYLPLTFWITLLDAFYQSLVCFFVPYFTYQGSDIDIFTFGNPLNTAALFIILLHLVIESKSLT 1302

  Fly  1394 VLHVLSIVLSLGSFYLFAIVYDSVCMNCFGVRSSYWVIFVCFASAVHWLVIMLSTVVAVLPRLLL 1458
            .:|:|..|.|:.|::.||:.:.::|:.|....:.|.::.......|.:||.:|:|.||:|||.|.
Mouse  1303 WIHMLVTVGSILSYFFFALAFGALCVTCNPPSNPYGIMRKHMLDPVFYLVCVLTTFVALLPRFLY 1367

  Fly  1459 TTVRISLCPDDSTKVILQSK-----RERSRGEAL 1487
            ..::.|:.|..    :|::|     ....|.|||
Mouse  1368 RVLQGSVFPSP----VLRAKYFDRLPPEERAEAL 1397

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG33298	NP_995666.1	P-type_ATPase_APLT_Dnf-like	252..1355	CDD:319770	503/1206 (42%)
Atp10d	NP_700438.3	P-type_ATPase_APLT_Dnf-like	126..1264	CDD:319770	503/1206 (42%)
		Haloacid Dehalogenase-like Hydrolases	<480..>602	CDD:473868	40/121 (33%)