DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33225 and PLG

DIOPT Version :9

Sequence 1:	NP_001286682.1	Gene:	CG33225 / 2768860	FlyBaseID:	FBgn0053225	Length:	307	Species:	Drosophila melanogaster
Sequence 2:	NP_000292.1	Gene:	PLG / 5340	HGNCID:	9071	Length:	810	Species:	Homo sapiens

Alignment Length:	262	Identity:	81/262 - (30%)
Similarity:	119/262 - (45%)	Gaps:	40/262 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 DCGTTR-HPSRI-RRVVGGNDADRFANPWMVMVLGENNV-FCSGSLITRLFVLTSASCLLSLPK- 104
            |||..: .|.:. .|||||..|...:.||.|.:.....: ||.|:||:..:|||:|.||...|:
Human   566 DCGKPQVEPKKCPGRVVGGCVAHPHSWPWQVSLRTRFGMHFCGGTLISPEWVLTAAHCLEKSPRP 630

  Fly   105 ---QVILGEYDRNCTSADCTSIRQVIDID---QKIIHGQFGLETVKKYDIALLRLAKKVSISDYV 163
               :||||.:             |.::::   |:|...:..||..:| |||||:|:....|:|.|
Human   631 SSYKVILGAH-------------QEVNLEPHVQEIEVSRLFLEPTRK-DIALLKLSSPAVITDKV 681

  Fly   164 RPICLSVDRQVGRSVQHFTATGWGTTEWNEPSTILQTVTLSKINRKYCKGR--LRQNIDASQLCV 226
            .|.||.....|.........||||.|:....:.:|:...|..|..|.|...  |...:.:::||.
Human   682 IPACLPSPNYVVADRTECFITGWGETQGTFGAGLLKEAQLPVIENKVCNRYEFLNGRVQSTELCA 746

  Fly   227 G--GPRKDTCSGDAGGPLSLTLKIDGDGKWNNKSRAFLIGIVSYGSSSC--SGIGVYTNVEHYMD 287
            |  ....|:|.||:||||...          .|.:..|.|:.|:|....  :..|||..|..::.
Human   747 GHLAGGTDSCQGDSGGPLVCF----------EKDKYILQGVTSWGLGCARPNKPGVYVRVSRFVT 801

  Fly   288 WI 289
            ||
Human   802 WI 803

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33225	NP_001286682.1	Tryp_SPc	56..289	CDD:214473	75/246 (30%)
CG33225	NP_001286682.1	Tryp_SPc	57..292	CDD:238113	76/247 (31%)
PLG	NP_000292.1	PAN_AP_HGF	<38..97	CDD:238532
		KR	101..183	CDD:214527
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	126..145
		KR	183..263	CDD:214527
		KR	273..354	CDD:214527
		KR	375..456	CDD:214527
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	396..416
		KR	479..560	CDD:214527
		Tryp_SPc	580..803	CDD:214473	75/246 (30%)
		Tryp_SPc	581..804	CDD:238113	76/247 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910