DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33225 and TMPRSS6

DIOPT Version :9

Sequence 1:	NP_001286682.1	Gene:	CG33225 / 2768860	FlyBaseID:	FBgn0053225	Length:	307	Species:	Drosophila melanogaster
Sequence 2:	NP_001275929.1	Gene:	TMPRSS6 / 164656	HGNCID:	16517	Length:	824	Species:	Homo sapiens

Alignment Length:	287	Identity:	81/287 - (28%)
Similarity:	117/287 - (40%)	Gaps:	58/287 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 DCGTTRHPSRIRRVVGGNDADRFANPWMVMVLGENNVFCSGSLITRLFVLTSASCLL--SLPKQV 106
            ||| .:.||  .|:|||..:.....||...:.......|.|:||...:|:|:|.|..  |:...|
Human   558 DCG-LQGPS--SRIVGGAVSSEGEWPWQASLQVRGRHICGGALIADRWVITAAHCFQEDSMASTV 619

  Fly   107 I----LGEYDRNCTSADCTSIRQVIDIDQKIIHGQFGLETVKKYDIALLRLAKKVSISDYVRPIC 167
            :    ||:..:|.......|.:    :.:.::| .:..|....||:|||:|...|..|..|||:|
Human   620 LWTVFLGKVWQNSRWPGEVSFK----VSRLLLH-PYHEEDSHDYDVALLQLDHPVVRSAAVRPVC 679

  Fly   168 LSVDRQVGRSVQHFTATGWGTTE--------------WNEP---------STILQTVTLSKINRK 209
            |...........|...||||...              |...         |..||.|.:..|.:.
Human   680 LPARSHFFEPGLHCWITGWGALREGALRADAVALFYGWRNQGSETCCCPISNALQKVDVQLIPQD 744

  Fly   210 YCKGRLRQNIDASQLCVG--GPRKDTCSGDAGGPL---SLTLKIDGDGKWNNKSRAFLIGIVSYG 269
            .|....|..:....||.|  ..:||.|.||:||||   :|:      |:|      ||.|:||:|
Human   745 LCSEVYRYQVTPRMLCAGYRKGKKDACQGDSGGPLVCKALS------GRW------FLAGLVSWG 797

  Fly   270 SSSC---SGIGVYTNVEHYMDWIVRTI 293
             ..|   :..||||.:...:.||.:.:
Human   798 -LGCGRPNYFGVYTRITGVISWIQQVV 823

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33225	NP_001286682.1	Tryp_SPc	56..289	CDD:214473	74/269 (28%)
CG33225	NP_001286682.1	Tryp_SPc	57..292	CDD:238113	75/271 (28%)
TMPRSS6	NP_001275929.1	SEA	77..177	CDD:307516
		CUB	326..440	CDD:238001
		LDLa	450..480	CDD:238060
		LDLa	486..516	CDD:238060
		Ldl_recept_a	520..557	CDD:278486
		Tryp_SPc	568..822	CDD:238113	75/271 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910